Causes of hemorrhagic complications in hospitalized patients receiving therapeutic doses of anticoagulants

Chernov, Anton A.; Kleymenova, E. B.; Sychev, D.A.; Abilmazhinova, A.A.; Yashina, L. P.; Отделенов, В. А.; Payushchik, S. A.

doi:10.32756/0869-5490-2018-5-23-29

Cited by 4 publications

(1 citation statement)

References 12 publications

(22 reference statements)

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“…Согласно проведенному нами поиску в специализированной отечественной литературе, методика учета DRP практически не используется в российской практике, а количество исследований лекарственных проблем единично [21,22].…”

Section: Introductionunclassified

Application of Drug-Related Problems Approach to Analysis of Non-Steroidal Anti-Inflammatory Drugs’ Safety

Матвеев¹,

Крашенинников²,

Егорова

et al. 2019

Farm. farmakol. (Pâtigorsk)

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A Drug-Related Problem is an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes.The aim of the study was the analysis of the adverse drug reactions (ADR) associated with prescription of the non-steroidal anti-inflammatory drugs (NSAIDs) using the DRP PCNE V5.01 qualification system.Materials and methods. The objects of the study were 415 notification forms about adverse drug reactions of NSAIDs recorded in the regional database of spontaneous reports and called ARCADe (Adverse Reactions in Crimea, Autonomic Database) for the period from 1 January 2009 to 31 December of 2018. The study and analysis of the problems associated with drugs were carried out using the qualification system DRP PCNE V5.01 (Pharmaceutical Care Network Europe) 2006 in the modification of Prof. Zimenkovsky.Results. Among other representatives of the NSAID group, Ibuprofen and Diclofenac became the “leaders” in the incidence of ADR. The frequency of ADR cases for Ibuprofen was 142 reports (34.22% of the total number of ADR for NSAIDs), and for Diclofenac it was 90 cases (21.69%). The calculation of DRP values for each of the presented cases made it possible to determine that in 81 (19.51%) and 91 (21.9%) cases, the DRP value was 6 and 7, respectively. DRP values in the range of 8–10 were found in 92 reports. The highest DRPs value was observed after the administration of Parecoxib (13 problems but only one case was found in the database), the DRPs value of Dexketoprofen was 12.5 (95% CI: 7–17) and the DRPs value of Diclofenac combinations was 10 DRPs; 95% CI: 5–17 DRP). The minimum DRPs values were associated with Naproxen, Rofecoxib, and Etoricoxib prescriptions.Conclusion. Using the DRP system in the analysis of NSAIDs, ADRs allow to identify the medicines which have a high risk of causing safety problems, such as Parecoxib, Dexketoprofen and Diclofenac combinations. The prescription of these drugs should be carried out with special cautions and control to the indications and contraindications, the dose and duration of treatment, as well as to a possible interaction of them with concomitant drugs.

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Section: Introductionunclassified

Application of Drug-Related Problems Approach to Analysis of Non-Steroidal Anti-Inflammatory Drugs’ Safety

Матвеев¹,

Крашенинников²,

Егорова

et al. 2019

Farm. farmakol. (Pâtigorsk)

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Prospects for the development of pharmacogenetics in Russia for the personalization of pharmacotherapy

Sychev,

Mirzaev,

Denisenko

2023

jour

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Review of publications on drug-related problems investigations in osteoporosis patients

Egorova,

Beitullaev,

Matveev

et al. 2024

Farm. farmakol. (Pâtigorsk)

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A chronic form of osteoporosis (OP) substantiates a long-term pharmacotherapy of patients, which increases the risk of adverse drug reactions (ADRs) during the therapy. The enhancement of requirements to the quality of safety monitoring carried out in the context of pharmacovigilance and the newly identified safety problems require an improvement of the system of quality control of medicinal products (MPs).The aim of the work was to review the application of a new promising method for monitoring the drug safety – the system of Drug-Related Problems (DRP) in the osteoporosis pharmacotherapy.Materials and methods. The following databases and search engines were used to retrieve scientific papers by Russian and foreign authors: PubMed, elibrary.ru, Google Scholar, CyberLeninka, Russian National Library. The information sources were searched using the following keywords and word combinations: “drug-related problems”, “drug safety”, “osteoporosis” (in Russian and English, respectively), as well as the corresponding MeSH terms.Results. The application of DRP system in the health care of different countries was reviewed, and the risk factors of the problems associated with the use of MPs, the appropriate interventions in case of the detection of high DRP values were investigated. The study of the problems associated with the use of MPs for the treatment of OP during the complex pharmacotherapy made it possible to determine the feasibility of using this method to improve the safety and effectiveness of this kind of treatment in patients.Conclusion. The analysis of emerging DRPs makes it possible to increase patients’ adherence to the treatment and stop the ADRs. This improves the quality of life of patients and increases the effectiveness of pharmacotherapy. The introduction of such a method of the drug safety research into the system of pharmacovigilance of the Russian Federation is an important step in the development of personalized medicine. A further study of problems associated with the use of drugs in OP patients will also help to reduce the risks arising during the combination pharmacotherapy.

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Causes of hemorrhagic complications in hospitalized patients receiving therapeutic doses of anticoagulants

Cited by 4 publications

References 12 publications

Application of Drug-Related Problems Approach to Analysis of Non-Steroidal Anti-Inflammatory Drugs’ Safety

Application of Drug-Related Problems Approach to Analysis of Non-Steroidal Anti-Inflammatory Drugs’ Safety

Prospects for the development of pharmacogenetics in Russia for the personalization of pharmacotherapy

Review of publications on drug-related problems investigations in osteoporosis patients

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