“…Such comparisons are limited because total knee replacement is not a chronic disease. However, similar to living with a chronic condition, undergoing elective surgery and living with a prosthetic implant lead to increased health-care utilization and carry small but clearly defined health risks, including joint infection, periprosthetic fracture, symptomatic implant loosening, and implant wear 11 . While annual rates of these adverse outcomes are low, with millions of adults in the U.S. living with total knee replacement over a prolonged period, these complications pose a potentially large public health burden.…”