Motor activity and spasm were for many years regarded as factors of great importance in the genesis and symptomatology of chronic peptic ulcer. In recent times, however, the factor of myospasm has claimed far less attention, the emphasis being placed almost entirely on acidity as being of greatest significance in the etiology, symptomatology and therapy of peptic ulceration. There is little reference in current literature to the relief of muscle spasm as a factor of importance in the healing of peptic ulcer.It is suggested that motor activity is in fact an important element in the pathology and clinical features of chronic peptic ulcer. There are numerous conditions in which myospasm and peptic ulcer are associated and also some conditions of gastrointestinal hypotonia in which peptic ulcer is rarely found.