Causes of death among cancer patients

Zaorsky, Nicholas G.; Churilla, Thomas M.; Egleston, Brian L.; Fisher, Susan G.; Ridge, John A.; Horwitz, Eric M.; Meyer, Joshua E.

doi:10.1093/annonc/mdw604

Cited by 470 publications

(474 citation statements)

References 28 publications

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“…The 5‐year survival rates of many cancers have been improved considerably. A recent study has highlighted that the risk of non‐cancer deaths have surpassed that of cancer deaths . In this study, the 6‐month period after the first cancer diagnosis of cancer was found to be the most risky period with respect to committing suicide.…”

Section: Discussionmentioning

confidence: 73%

“…Several studies have provided evidence supporting the elevated risk of suicide within 1 year after cancer diagnosis . However, the risk of suicide within the hazard period is unclear and few studies have involved unbiased comparison groups.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, all patients with first cancer diagnoses after 2002 were included in this study, and the study period was defined as the 13‐month duration preceding the suicide date. The major consideration to use the 13th month antecedent to the suicide death as the control index period was based on previous studies that showed the highest hazard period for suicide was within the first year following cancer diagnosis . The control period therefore was chosen to account for potentially varying baseline risk over time.…”

Section: Methodsmentioning

confidence: 99%

“…Zaorsky et al . found that the highest suicide risk was within the first year following cancer diagnosis . Fang et al .…”

mentioning

confidence: 99%

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Risk of suicide within 1 year of cancer diagnosis

Wang

Chang

Weng

et al. 2018

Intl Journal of Cancer

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The association of the risk of suicide with cancer at different time points after a new cancer diagnosis is unclear. This study explored the suicide hazard at different time points after a first cancer diagnosis during the 1-year period before suicide. This case-crossover study included 2,907 suicide cases from 2002 to 2012 in Taiwan and compared the odds of suicide risk at different time points during one year after any cancer diagnosis with self-matched periods. The 13th month preceding the suicide date was used as the control period, and the hazard period was the duration from the 1st to 12th month in the conditional logistic regression for case-crossover comparisons. Among major groups of cancers, group of lip, oral cavity and pharynx cancers tended to have higher risk of suicide than other groups of cancers. The first month of cancer diagnosis was associated with the highest risk of suicide compared with the 13th month before suicide. The odds ratio (OR) of suicide were significantly in the first six months after cancer diagnosis but declined afterwards. For example, the adjusted OR was 3.47 [95% confidence interval (CI) = 2.60-4.62] in the first month and 1.53 (95% CI = 1.11-2.12) in the sixth month following cancer diagnosis. These findings provide clinicians with a vital reference period during which sufficient support and necessary referral to mental health support should be provided to reduce the risk of suicide among patients with newly diagnosed cancer morbidity.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Zaorsky et al . found that the highest suicide risk was within the first year following cancer diagnosis . Fang et al .…”

mentioning

confidence: 99%

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Risk of suicide within 1 year of cancer diagnosis

Wang

Chang

Weng

et al. 2018

Intl Journal of Cancer

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“…For localized prostate cancer treated with definitive EBRT, the data on the effect of treatment interruptions are limited and conflicting . In contrast, prostate cancer is generally an indolent disease: rates of freedom from biochemical failure are typically >85% at 5–10 years from diagnosis, >80% of men are alive 5–10 years from diagnosis, and over 60% of patients die of non‐cancer causes …”

Section: Introductionmentioning

confidence: 99%

Effects of interruptions of external beam radiation therapy on outcomes in patients with prostate cancer

Lango

Zaorsky

et al. 2017

J Med Imag Rad Onc

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Cardio-Oncology Rehabilitation for Cancer Survivors With High Cardiovascular Risk

Viamonte,

Joaquim,

Alves

et al. 2023

JAMA Cardiol

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ImportanceCardiovascular disease is a leading cause of morbidity in cancer survivors, which makes strategies aimed at mitigating cardiovascular risk a subject of major contemporary importance.ObjectiveTo assess whether a center-based cardiac rehabilitation (CBCR) framework compared with usual care encompassing community-based exercise training (CBET) is superior for cardiorespiratory fitness improvement and cardiovascular risk factor control among cancer survivors with high cardiovascular risk.Design, Setting, and ParticipantsThis prospective, single-center, randomized clinical trial (CORE trial) included adult cancer survivors who had exposure to cardiotoxic cancer treatment and/or previous cardiovascular disease. Enrollment took place from March 1, 2021, to March 31, 2022. End points were assessed at baseline and after the 8-week intervention.InterventionsParticipants were randomly assigned in a 1:1 ratio to 8 weeks of CBCR or CBET. The combined aerobic and resistance exercise sessions were performed twice a week.Main Outcomes and MeasuresThe powered primary efficacy measure was change in peak oxygen consumption (V̇o2) at 2 months. Secondary outcomes included handgrip maximal strength, functional performance, blood pressure (BP), body composition, body mass index (BMI; calculated as weight in kilograms divided by height in meters squared), lipid profile, plasma biomarker levels, physical activity (PA) levels, psychological distress, quality of life (QOL), and health literacy.ResultsA total of 75 participants completed the study (mean [SD] age, 53.6 [12.3] years; 58 [77.3%] female), with 38 in the CBCR group and 37 in the CBET group. Participants in CBCR achieved a greater mean (SD) increase in peak V̇o2 than those in CBET (2.1 [2.8] mL/kg/min vs 0.8 [2.5] mL/kg/min), with a between-group mean difference of 1.3 mL/kg/min (95% CI, 0.1-2.6 mL/kg/min; P = .03). Compared with the CBET group, the CBCR group also attained a greater mean (SD) reduction in systolic BP (−12.3 [11.8] mm Hg vs −1.9 [12.9] mm Hg; P &lt; .001), diastolic BP (−5.0 [5.7] mm Hg vs −0.5 [7.0] mm Hg; P = .003), and BMI (−1.2 [0.9] vs 0.2 [0.7]; P &lt; .001) and greater mean (SD) improvements in PA levels (1035.2 [735.7] metabolic equivalents [METs]/min/wk vs 34.1 [424.4] METs/min/wk; P &lt; .001), QOL (14.0 [10.0] points vs 0.4 [12.9] points; P &lt; .001), and health literacy scores (2.7 [1.6] points vs 0.1 [1.4] points; P &lt; .001). Exercise adherence was significantly higher in the CBCR group than in the CBET group (mean [SD] sessions completed, 90.3% [11.8%] vs 68.4% [22.1%]; P &lt; .001).Conclusion and RelevanceThe CORE trial showed that a cardio-oncology rehabilitation model among cancer survivors with high cardiovascular risk was associated with greater improvements in peak V̇o2 compared with usual care encompassing an exercise intervention in a community setting. The CBCR also showed superior results in exercise adherence, cardiovascular risk factor control, QOL, and health literacy.Trial RegistrationClinicalTrials.gov Identifier: NCT05132998

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Causes of death among cancer patients

Abstract: The risk of death from index- and nonindex-cancers varies widely among primary sites. Risk of noncancer deaths now surpasses that of cancer deaths, particularly for young patients in the year after diagnosis.

Cited by 470 publications

References 28 publications

Risk of suicide within 1 year of cancer diagnosis

Risk of suicide within 1 year of cancer diagnosis

Effects of interruptions of external beam radiation therapy on outcomes in patients with prostate cancer

Cardio-Oncology Rehabilitation for Cancer Survivors With High Cardiovascular Risk

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