Causes of death after laryngeal cancer diagnosis: A US population-based study

Abstract

Background Several reports examined the survival of laryngeal cancer (LC) patients, most of these studies only focused on the prognosis of the disease, and just a small number of studies examined non-cancer-related causes of death. The objective of the current study is to investigate and quantify the most common causes of deaths following LC diagnosis. Methods The data of 44,028 patient with LC in the United States diagnosed between 2000 and 2018 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) program and analyzed. We stratified LC patients according to various demographic and clinical parameters and calculated standardized mortality ratios (SMRs) for all causes of death. Results Over the follow-up period, 25,407 (57.7%) deaths were reported. The highest fatalities (11,121; 43.8%) occurred within 1–5 years following LC diagnosis. Non-cancer causes of death is the leading cause of death (8945; 35.2%), followed by deaths due to laryngeal cancer (8,705; 34.3%), then other cancers deaths (7757; 30.5%). The most common non-cancer causes of death were heart diseases (N = 2953; SMR 4.42), followed by other non-cancer causes of death (N = 1512; SMR 3.93), chronic obstructive pulmonary diseases (N = 1420; SMR 4.90), then cerebrovascular diseases (N = 547; SMR 4.28). Compared to the general population, LC patients had a statistically significant higher risk of death from all reported causes. Conclusions Non-cancer causes of death is the leading cause of death in LC patients, exceeding deaths attributed to LC itself. These findings provide important insight into how LC survivors should be counselled regarding future health risks.

Cause of death among gastric cancer survivors in the United States from 2000 to 2020

“…on other cancers. [12][13][14][15][16][17] Most causes of death had a significantly higher risk of death compared to cancer-free populations in the United States. The risks of death from the majority of COD demonstrated a downward trend over time.…”

“…[11] The most common noncancerous causes of death were diseases of heart and cerebrovascular diseases, which were consistent with findings from several previous studies on various cancers. [11][12][13][14][15][16][17][18] This association may be related to GC treatment. For example, immunotherapy is probably associated with cardiac toxic effects, and HER-2 targeted Trastuzumab may lead to a decrease in left ventricular ejection fraction.…”

“…The main noncancerous causes of death were diseases of heart, cerebrovascular disease and COPD, which paralleled previous studies on other cancers. [12–17] Most causes of death had a significantly higher risk of death compared to cancer-free populations in the United States. The risks of death from the majority of COD demonstrated a downward trend over time.…”

“…Death statistics were obtained from SEER case listing of Incidence-Based Mortality (IBM), 17 Registries, Nov 2022 Sub . IBM cases can be calculated using variables such as age, sex and tumor stage.…”

Causes of death and nomogram for patients with oncologic hepato-biliary-pancreatic disorders: A large-cohort study

“…A large number of studies on COD and survival of cancer patients have been carried out, most of which focusing on only 1 malignancies. [13][14][15][16][17][18][19] Our study is unique as it explored specific COD and prognosis of 4 malignancies in hepota-biliary-pancreatic system using newest large-cohort from SEER database.…”