2021
DOI: 10.21203/rs.3.rs-341195/v1
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Causes of Altered Ventricular Mechanics in Hypertrophic Cardiomyopathy—an In-Silico Study

Abstract: Background: Hypertrophic cardiomyopathy is a common heart disease causing alteration in the mechanical behaviour of the left ventricle (LV). Decreased myocardial velocities, reduced strain and strain rates have been reported clinically. These alterations result from underlying pathological mechanisms in the tissue: increased wall thickness, altered active and passive force development and/or fiber disarray, which are cumbersome to measure clinically. With a numerical study, we aim to answer: how the variabilit… Show more

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