Causes for Hospitalization and Death in Iranian Patients with β-Thalassemia Major

Bazrgar, Masood; Peiravian, Farah; Abedpour, Fatemeh; Karimi, Mehran

doi:10.3109/08880018.2010.503336

Cited by 17 publications

(10 citation statements)

References 17 publications

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“…The selection flow chart is shown in Figure 1. Of the included studies, seven studies [30, 33, 34, 36, 39, 40, 43] were from Italy; seven studies [14, 16, 18, 20, 21, 31, 42] were from Iran; five studies [17, 19, 27, 44, 45] were from Egypt; five studies [4, 8, 22, 23, 35] were from the China region, including the mainland [22], Hong Kong [23], and Taiwan [4, 8, 35]; three studies [11, 12, 32] were from India; two studies [41, 47] were from Arabia; one study [37] was from Germany. The other studies were from Australia [26], Brazil [3], France [9], Lebanon [41], Oman [15], Turkey [25, 38], the United Kingdom [46], and the United States of America [2].…”

Section: Resultsmentioning

confidence: 99%

Elevated Prevalence of Abnormal Glucose Metabolism and Other Endocrine Disorders in Patients withβ-Thalassemia Major: A Meta-Analysis

Cui

Yang

et al. 2019

BioMed Research International

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Background. Endocrinopathies are common in patients withβ-thalassemia major despite parenteral iron chelation therapy with deferoxamine. Prevalence of abnormal glucose metabolism in previous studies was controversial. The aim of this study was to discuss the prevalence of abnormal glucose metabolism inβ-thalassemia major based on a meta-analysis.Methods. PubMed, ScienceDirect, Springerlink, Ovid, Web of Science, MEDLINE, Wanfang database, and Chinese National Knowledge Internet were searched for relevant articles. Two authors selected the articles according to the inclusion criteria and then extracted the data. The prevalence of diabetes mellitus (DM) inβ-thalassemia major was defined as the primary outcome. The prevalence with the 95% confidence interval (95%CI) was used to evaluate the proportion of abnormal glucose metabolism and other endocrine disorders in patients withβ-thalassemia major. Subgroup analyses were applied to explore the prevalence in different regions. Sensitivity analysis and publication bias assessment were also conducted.Results. A total of 44 studies with 16605 cases were included in this analysis. Diabetes mellitus was present in 6.54% (95% CI: 5.30%-7.78%). The fixed subgroup study revealed that the region with the highest prevalence was the Middle East (prevalence= 7.90%, 95% CI: 5.75%-10.05%). The accumulated meta-analysis revealed that the prevalence of DM inβ-thalassemia major was relatively steady in each year. The prevalence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and other endocrine disorders inβ-thalassemia major was 17.21% (95% CI: 8.43%-26.00%), 12.46% (95% CI: 5.98%-18.94%), and 43.92% (95% CI: 37.94%-49.89%), respectively. Sensitivity analysis showed that the pooled results were robust; publication bias assessment revealed that there was no significant evidence that the pooled results were influenced by publication bias.Conclusion. High prevalence of endocrine disorders involving abnormal glucose metabolism was detected inβ-thalassemia major. Treatment and prevention measurements may be necessary to prevent growth and endocrine problems.

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Section: Resultsmentioning

confidence: 99%

Elevated Prevalence of Abnormal Glucose Metabolism and Other Endocrine Disorders in Patients withβ-Thalassemia Major: A Meta-Analysis

Cui

Yang

et al. 2019

BioMed Research International

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“…In developing and underdeveloped countries, patients with TM die in childhood and adolescence due to the lack of public access to blood transfusions tested for viruses and timely iron removal from the body [4]. The underlying causes of death in patients with TM include iron overload and excess serum ferritin [5], which lead to cardiac disease, liver and endocrine disorders, infection, thrombosis, anemia, malignancy, and eventually death [6-9].…”

Section: Introductionmentioning

confidence: 99%

The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran

Ansari‐Moghaddam

Adineh²,

Zareban

et al. 2018

Epidemiol Health

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OBJECTIVESThalassemia is a common genetic disease in Iran, especially in the north and south of Iran. The present study sought to determine the survival rate of patients with thalassemia in highly endemic regions of Iran and its variation in patients born before and after 1971.METHODSThe present historical cohort study extracted data from the health records of patients with beta-thalassemia major, beta-thalassemia intermedia, and sickle beta-thalassemia who had presented to thalassemia treatment centers in the past years. The collected data were analyzed using the Kaplan-Meier test, the log-rank test, and the chi-square test.RESULTSOf the total of 5,491 medical records (2,647 men and 2,634 women; mean age, 23.81±11.32 years), 3,936 belonged to patients with beta-thalassemia major, and 999 and 89 to patients with beta-thalassemia intermedia and sickle beta-thalassemia, respectively. In 467 cases, the type of thalassemia was not clear. The cumulative survival rate was calculated as 0.92, 0.83, 0.74, and 0.51 by ages 25, 35, 45, and 55, respectively. The hazard ratio of death was 4.22 (p<0.05) for beta-thalassemia major and 0.77 for beta-thalassemia intermedia (p=0.70). It was calculated as 1.45 for men patients and as 3.82 for single patients.CONCLUSIONSThe present study showed relatively high survival rates in patients with thalassemia. The survival of patients was unfavorable in poorer regions (Zahedan and Iranshahr). Factors including women gender, a higher level of education, being married, and living in metropolises decreased the risk of death at younger ages and improved survival.

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“…The main cause of mortality in patients with thalassemia major is infectious disease . Splenectomized patients are particularly susceptible to infections caused by encapsulated microorganisms such as Streptococcus pneumoniae , Haemophilus influenzae and Neisseria meningitidis .…”

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Fatal sepsis in a child with thalassemia major due to Serratia marcescens

Paksu

Karli

Paksu

et al. 2014

Pediatrics International

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One of the most important causes of mortality in thalassemic patients is infectious disease. Thalassemic patients develop severe invasive infection caused by microorganisms that are rare in healthy individuals. We describe the case of a 13-year-old splenectomized boy who presented with septic shock and who died 36 h after admission, despite broad-spectrum antibiotics and aggressive supportive care. Serratia marcescens was isolated from cultures of blood and tracheal aspirate. It is known that rare microorganisms will cause severe community-acquired infection in splenectomized patients with thalassemia major.

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Causes for Hospitalization and Death in Iranian Patients with β-Thalassemia Major

Cited by 17 publications

References 17 publications

Elevated Prevalence of Abnormal Glucose Metabolism and Other Endocrine Disorders in Patients withβ-Thalassemia Major: A Meta-Analysis

Elevated Prevalence of Abnormal Glucose Metabolism and Other Endocrine Disorders in Patients withβ-Thalassemia Major: A Meta-Analysis

The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran

Fatal sepsis in a child with thalassemia major due to Serratia marcescens

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