Causes and outcome predictors of traumatic brain injury among emergency admitted pediatric patients at Cairo University Hospitals

Youssef, Meray Rene Labib; Galal, Yasmine Samir

doi:10.1097/01.epx.0000473569.10092.e7

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…Traumatic brain injury (TBI) is a main reason of death and morbidity, especially at both ends of the age range, which brings enormous costs to society [1]. Statistics have shown increased incidence, mortality, and disability of TBI in recent years [2].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Downregulated lncRNA CRNDE contributes to the enhancement of nerve repair after traumatic brain injury in rats

Dai

et al. 2019

Cell Cycle

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Objective: Long non-coding RNAs (lncRNAs) have recently been demonstrated to be involved in craniocerebral disease, but their expression in traumatic brain injury (TBI) is still unearthed. Therefore, we aimed to elucidate the effect of lncRNA CRNDE on TBI. Methods: Firstly, CRNDE expression was determined in serum of TBI patients and healthy controls. The TBI rat model was established based on Feeney's freefall impact method. The modeled rats were injected with siRNA against CRNDE, and the rats' neurobehavioral function were measured. Besides, expression of inflammatory factors, size, shape and number of hippocampal neurons, neuron apoptosis, Beclin I, LC3-I, LC3-II, glial fibrillary acidic protein (GFAP), BrdU, nerve growth factor (NGF), nestin, and neuronal nuclei (NeuN) expression were detected through different methods.Results: In TBI, CRNDE was found to be upregulated. Downregulated CRNDE improved neurobehavioral function, repressed expression of neuroinflammatory factors, elevated number of Nissl bodies, as well as restricted neuronal apoptosis and autophagy in TBI rats. Besides, downregulated CRNDE also promoted expression of GFAP, BrdU, NGF, nestin, and NeuN, thus induced the differentiation of neurons and the directional growth and regeneration of nerve fibers. Conclusion: Altogether, we found that silencing of CRNDE might be able to promote the nerve repair after TBI in rats.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Downregulated lncRNA CRNDE contributes to the enhancement of nerve repair after traumatic brain injury in rats

Dai

et al. 2019

Cell Cycle

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“…One study of physicians in the region found poor knowledge in correctly diagnosing cases of CM [ 31 ]. Yet, studies from ECS in Africa have found the burden of intentional injuries to be higher, between 18 and 21.3% [ 32 , 33 ]. Training health care providers to recognize warning signs of CM is critical for timely intervention and prevention [ 27 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

A cross-sectional exploratory study of knowledge, attitudes, and practices of emergency health care providers in the assessment of child maltreatment in Maputo, Mozambique

Pinto¹,

Lein

Mahoque³

et al. 2018

BMC Emerg Med

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BackgroundIn Mozambique, and other low-income countries (LICs), there is little information on the burden of child maltreatment (CM). Emergency care services (ECS) play an important role in recognizing, treating, and intervening in situations of CM. We aim to identify knowledge, attitudes, and practices regarding CM among health care providers in ECS at Mavalane General Hospital in Maputo, Mozambique.MethodsThis exploratory cross-sectional study evaluates the knowledge, attitudes, and practices of health care providers to diagnose and treat cases of CM. A 25 min, pilot-tested verbal interview questionnaire was administered to 49 physicians and nurses working in ECS at Mavalane General Hospital. Interviews were completed between October–November 2010. Data were managed and analyzed in SPSS 14.0 and descriptive statistics were generated.ResultsOf 49 health care providers, 83.6% reporting receiving no, or very little CM education or training. Only 61.2% had knowledge of physical abuse as a main form of child maltreatment and 38.8% were able to identify corresponding symptoms of physical abuse. Sexual abuse as a main form of CM was mentioned by 26.5 and 2% cited its symptoms. While 87.7% of health care providers strongly agreed or agreed that they hold an important role in preventing CM, 51.1% also strongly disagreed or disagreed that they feel confident diagnosing and treating CM cases. In regards to follow-up, 14.3% strongly disagreed or disagreed that they know where to refer victims for further follow-up and an additional 14.3% did not know whether they agreed or disagreed.ConclusionThis study revealed knowledge gaps in emergency health care provider knowledge of the main forms of CM and their symptoms. The fact that a majority of health care providers in our sample did not receive information specific to CM in their medical education and training could explain this gap, as well as their unawareness of where to refer victims. Given that health care providers believe they play an important role in identifying and treating CM, future research should focus on raising physician awareness of CM and developing education and training materials grounded in cultural contexts to build response capacity in Mozambique and other LICs.

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“…Early life exposure to adverse childhood experiences such as trauma, abuse, or maltreatment has been linked to developmental delays and mental health problems. 34 Childhood neglect and abuse is also one of the most prominent predisposing factors to TBI 36 as it can lead to increased risk of sustaining injuries or experiencing the persistent lingering effects of TBI. Individuals who sustained a TBI also report greater functional restrictions and disabilities compared with controls, 37 which can possibly also contribute to stress and risk of further injury.…”

Section: Discussionmentioning

confidence: 99%

Associations between Traumatic Brain Injury, Drug Abuse, Alcohol Use, Adverse Childhood Events, and Aggression Levels in Individuals with Foster Care History

Cusimano

Zhang

Huang

et al. 2020

Neurotrauma Reports

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Causes and outcome predictors of traumatic brain injury among emergency admitted pediatric patients at Cairo University Hospitals

Cited by 6 publications

References 25 publications

RETRACTED ARTICLE: Downregulated lncRNA CRNDE contributes to the enhancement of nerve repair after traumatic brain injury in rats

RETRACTED ARTICLE: Downregulated lncRNA CRNDE contributes to the enhancement of nerve repair after traumatic brain injury in rats

A cross-sectional exploratory study of knowledge, attitudes, and practices of emergency health care providers in the assessment of child maltreatment in Maputo, Mozambique

Associations between Traumatic Brain Injury, Drug Abuse, Alcohol Use, Adverse Childhood Events, and Aggression Levels in Individuals with Foster Care History

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