Causes and Consequences of MicroRNA Dysregulation Following Cerebral Ischemia-Reperfusion Injury

Forouzanfar, Fatemeh; Shojapour, Mana; Asgharzade, Samira; Amini, Elham

doi:10.2174/1871527318666190204104629

Cited by 19 publications

(7 citation statements)

References 82 publications

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“…( 2) The common non-coding RNA consists of lncRNAs and miRNAs, and miRNAs have especially attracted considerable attention in cerebral I/R injuries studies in recent years (Ghafouri-Fard et al, 2020). miRNAs can not only influence gene expression by inhibiting mRNA translation or inducing degradation of mRNA, but also act as damage-associated molecular patterns and cofactors activating inflammatory cascades and thrombosis (Hu et al, 2015;Forouzanfar et al, 2019;Mahjoubin-Tehran et al, 2021). Studies show that PF could alleviate brain damage by manipulating miR-210 (Jiang et al, 2021) and miR-135a (Zhai et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis

et al. 2022

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Background: Vessel recanalization is the main treatment for ischemic stroke; however, not all patients benefit from it. This lack of treatment benefit is related to the accompanying ischemia-reperfusion (I/R) injury. Therefore, neuroprotective therapy for I/R Injury needs to be further studied. Paeonia lactiflora Pall. is a commonly used for ischemic stroke management in traditional Chinese medicine; its main active ingredient is paeoniflorin (PF). We aimed to determine the PF’s effects and the underlying mechanisms in instances of cerebral I/R injury.Methods: We searched seven databases from their inception to July 2021.SYRCLE’s risk of bias tool was used to assess methodological quality. Review Manager 5.3 and STATA 12.0 software were used for meta-analysis.Results: Thirteen studies, including 282 animals overall, were selected. The meta-analyses showed compared to control treatment, PF significantly reduced neurological severity scores, cerebral infarction size, and brain water content (p = 0.000). In the PF treatment groups, the apoptosis cells and levels of inflammatory factors (IL-1β) decreased compared to those in the control groups (p = 0.000).Conclusion: Our results suggest that PF is a promising therapeutic for cerebral I/R injury management. However, to evaluate the effects and safety of PF in a more accurate manner, additional preclinical studies are necessary.

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Section: Discussionmentioning

confidence: 99%

Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis

et al. 2022

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“…An increasing number of reports have illustrated that dysregulation of miRNAs is closely associated with the pathogenesis of diverse diseases [40][41][42]. Numerous studies have shown that miRNAs are of immense significance in neurophysiological and neuropathological processes [43,44].…”

Section: Discussionmentioning

confidence: 99%

LncRNA CRNDE exacerbates neuropathic pain in chronic constriction injury-induced(CCI) rats through regulating miR-146a-5p/WNT5A pathway

Zhang¹,

Zhu

2021

Bioengineered

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Neuropathic pain (NP) originating from a dysfunction in the nervous system is often intractable and chronic. Many studies have implicated long noncoding RNAs (lncRNAs) in the physiological and pathological development of NP. The lncRNA colorectal neoplasia differentially expressed gene (CRNDE) has been shown to mediate NP progression. However, further investigations are needed to gain deeper understanding of the specific mechanisms governing CRNDE in NP etiopathology. In this study, we successfully used chronic constrictive injury (CCI)-induced rats to establish an NP model with intrathecal injection, and confirmed the upregulation of CRNDE in CCI-induced rats. Moreover, silencing of CRNDE relieved mechanical allodynia, thermal hyperalgesia, and neuroinflammation in the NP model. Bioinformatics analysis predicted that miR-146a-5p binds to CRNDE. Our findings validated that miR-146a-5p was a target of CRNDE and that the expression of miR-146a-5p was decreased in CCI rats. Furthermore, miR-151A-3p was found to exert a negative regulatory effect on WNT5A. In addition, knockdown of WNT5A alleviated the pain-related behavior and inflammatory response of NP in vivo. Finally, we demonstrated that CRNDE contributed to the progression of CCI-induced NP via competitive binding to miR-146a-5p to upregulate WNT5A. The present study offers novel insights that may be translated into improved therapies for NP.

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“…According to the author [20] the dysregulation of miRNAs following cerebral ischemia-reperfusion injury can occur due to multiple factors. Ischemia-reperfusion counting oxidative stress, in ammation, apoptotic cell death.…”

Section: Literature Surveymentioning

confidence: 99%

Biomarkers Classification for Various Brain Disease using Artificial Intelligence Approach-A Study

Reeja¹,

Mounika²,

Mohanty³

2023

Preprint

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Diagnostic and prognostic markers for disease identification Furthermore impact of treatment on the illness continues to be a significant restriction in science. As a matter of fact, initial determination and guess of the sickness are hindered by a lack of suitable markers, and as a result, many lives are lost due to a variety of diseases because diagnosis occurs too late for a severe form of the illness because it is challenging to comprehend a recurrence. An illness’s medical condition can be positively identified using biomarkers. Diagnostic biomarkers may be crucial in this situation to make a precise diagnosis, identify individuals with a disease, and classify people with the same type of condition to tailor pharmacological therapies and boost therapeutic response. As a result, these biomarkers may be helpful for more than only diagnosing diseases; they may also be able to anticipate how a patient will respond to treatment. Research in the biology of disease is therefore heavily focused on finding appropriate and useful biomarkers for disease. Finding disease-specific biomarkers has recently been aided by deep learning. Brain functional connectivity (FC) changes may serve as biomarkers for forecasting several types of brain diseases. When the alterations are modest and there aren't any major structural changes overall, fMRI may be able to find abnormalities in the brain that other imaging methods can't. FMRI analytics are frequently used in various brain investigations, even clinical trials, in conjunction with deep learning models.

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Causes and Consequences of MicroRNA Dysregulation Following Cerebral Ischemia-Reperfusion Injury

Cited by 19 publications

References 82 publications

Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis

Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis

LncRNA CRNDE exacerbates neuropathic pain in chronic constriction injury-induced(CCI) rats through regulating miR-146a-5p/WNT5A pathway

Biomarkers Classification for Various Brain Disease using Artificial Intelligence Approach-A Study

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