Cause of Clubbing

Doyle, Leslie

doi:10.1016/s0140-6736(59)91111-0

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…These authors suggested that arterial anoxaemia and an increased peripheral blood flow were important factors in the production of the disease. On the other hand, arterial shunts (Doyle 1959) or circulatory disturbances in the lungs (Jubb and Kennedy 1970) may lead to reflex vasomotor disturbances in the limbs, presumably by undue stimulation of nerves as they course along the vessels in the lung.…”

Section: Discussionmentioning

confidence: 99%

Hypertrophic Osteopathy and Dysgerminoma in a Mare

McLennan

Kelly

1977

Aust Veterinary J

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A case of hypertrophic osteopathy is described in a mare with a vague history of abdominal discomfort over the preceding 12 months. Bony swellings were obvious in the pastern area of both forelegs. There was a dysgerminoma of the left ovary that had metastasised to several abdominal lymph nodes and had infiltrated the posterior vena cava. There was no gross thoracic involvement although there was histologic evidence of tumour metastasis in pulmonary arterioles.

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Section: Discussionmentioning

confidence: 99%

Hypertrophic Osteopathy and Dysgerminoma in a Mare

McLennan

Kelly

1977

Aust Veterinary J

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Hypertrophic osteoarthropathy: estrogens, prostaglandinE2, prostaglandin A2, and the inflammatory reflex

et al. 2018

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It has been claimed that hyperestrogenism occurs in hypertrophic osteoarthropathy (HOA), but not in simple clubbing. However, one of our patients had simple clubbing and hyperestrogenism. We therefore measured estrogens, androgens, sex hormone-binding globulin (SHBG), and gonadotropins in five patients with HOA and in 18 patients with simple clubbing. Of the patients with HOA, 80% had a high urinary estriol concentration. In their serum, 80% had high estrone, 0% high estradiol, and 40% high SHBG. Of the patients with simple clubbing, 89% had a high urinary estriol concentration. In their serum, 76% had high estrone, 6% high estradiol, and 31% high SHBG. In all patients, urinary estriol concentration correlated positively with the degree of clubbing. Serum concentration of androstenedione, testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) was mostly normal, but androstenedione concentration correlated positively with the degree of clubbing. Spider angiomas were present in 74%, palmar erythema in 39%, and gynecomastia in 9%. Urinary creatinine concentration was low in 48% and correlated positively with the degree of clubbing. We reject the claim that hyperestrogenism occurs in HOA, but not in simple clubbing. Hyperestrogenism occurs both in HOA and in simple clubbing. Our results also support earlier reports that clubbing and HOA are associated with spider angiomas, palmar erythema, gynecomastia, adrenal cortical hyperfunction, muscle atrophy, and water retention. These results led to a new hypothesis on the pathogenesis of HOA, involving estrogens, prostaglandin E, prostaglandin A, and the inflammatory reflex.

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Pachydermoperiostosis (Idiopathic Clubbing and Periostosis)

Rimoin

1965

N Engl J Med

154

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Cause of Clubbing

Cited by 4 publications

References 2 publications

Hypertrophic Osteopathy and Dysgerminoma in a Mare

Hypertrophic Osteopathy and Dysgerminoma in a Mare

Hypertrophic osteoarthropathy: estrogens, prostaglandinE2, prostaglandin A2, and the inflammatory reflex

Pachydermoperiostosis (Idiopathic Clubbing and Periostosis)

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