Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer

Sullivan, Brian; Noujaim, Michael G.; Roper, Jatin

doi:10.1016/j.giec.2021.12.001

Cited by 34 publications

(15 citation statements)

References 136 publications

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“…There are certain risk factors for the transformation of adenomatous polyp into adenocarcinoma. The risk of cancer development from adenomatous polyps increases in the presence of polyps larger than 10 mm, multiple polyps, high villous components, and a high degree of dysplasia [3][4][5]24]. It was observed that DD especially increased the frequency of adenomatous polyps, similar to the studies in literature, while no change was observed in the incidence of serrated and hyperplastic polyps with DD.…”

Section: Resultssupporting

confidence: 84%

“…Adenomatous polyps are benign tumors of the colon with low-grade dysplasia. Sporadic colon adenocarcinoma progress from adenomatous polyps due to an increase in dysplasia with the effects of genetic and epigenetic changes [3]. Advanced age, increased number of polyps, larger polyp size (>10 mm), and high-grade dysplasia are risk factors for the development of malignancy from the polyp.…”

Section: Introductionmentioning

confidence: 99%

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Association between diverticular disease and prevalence of colorectal adenomatous polyps or adenocarcinomas

Gerçeker

Baykan

2022

J Surg Med

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Background/Aim: Although the link between diverticular disease (DD) of the colon and colon polyp is known, the relationship between colon adenocarcinoma is not clear. This study evaluated the association between DD and adenomatous polyp or colon adenocarcinoma. Methods: Patients who underwent colonoscopy for the first time in 2020-2021 were evaluated and included in this retrospective cohort study. Patients with a previous history of cancer diagnosis, colon surgery, DD, and inflammatory bowel disease were excluded from the study. Age, gender, colonoscopy indications, colonoscopy diagnoses, presence of DD, characteristics of polyps (pathology, diameter, number, localization), and presence of adenocarcinoma were recorded. Obtained data were analyzed between DD and non-DD groups. Results: A total of 2633 patients were included in the study. The prevalence of DD was 16.4%. Colon adenocarcinoma was detected in 4.7%. The adenomatous polyp rate was 14.1%. A significantly higher rate of adenomatous polyps was detected in the DD group compared to the non-DD group (19.7% vs. 12.9%; P = 0.001). Higher rates of high-grade dysplasia (3.0 vs. 1.1%; P = 0.002) and colon adenocarcinoma (7.2% vs. 4.2%; P = 0.008) were observed in the DD group also. In logistic regression analyses, it was observed that the presence of concomitant DD increases the risk of adenomatous polyps (OR: 1.469, 95% CI: 1.158–1.865), the risk of adenomatous polyps with positive villous component (OR: 2.378, 95% CI: 1.437–3.934), the risk of adenomatous polyps with high-grade dysplasia (OR: 2.822, 95% CI: 1.426–5.582), and the risk of colon adenocarcinoma (OR: 2.953, 95% CI: 1.445–6.533). Conclusion: DD is associated with precancerous lesions of the colon (adenomatous polyp, villous adenoma, high-grade dysplasia) and colon adenocarcinoma. Further studies are needed to investigate its association with colon carcinogenesis and its role and value in cancer screening.

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Section: Resultssupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Association between diverticular disease and prevalence of colorectal adenomatous polyps or adenocarcinomas

Gerçeker

Baykan

2022

J Surg Med

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“…Metastases significantly affect the mortality rate and pose a significant challenge for cancer therapies (2)(3)(4)(6)(7)(8). ADAM12 expression and EMT are associated with cancer metastasis and poor prognoses in various types of cancer, including CRC (10)(11)(12)(13)(14)(18)(19)(20)(21)(22)(28)(29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

“…Notably, metastasis is common in CRC, and is a major cause of morbidity and mortality. The liver is the most frequent site of metastasis, often occurring as a single metastatic site; however, ~20% of patients with CRC exhibit peritoneal metastasis, often at multiple metastatic sites (2)(3)(4). Compared with patients with oligometastasis which is characterized by the localization of the disease to a few sites with the option to use local ablative therapy (5), patients with CRC and peritoneal metastasis have a poorer overall survival (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition

Park

et al. 2023

Int J Oncol

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A disintegrin and metalloprotease 12 (ADAM12) and epithelial-mesenchymal transition (EMT) are linked in the metastasis of various types of cancer. The present study aimed to assess the ability of ADAM12 to induce EMT and its potential as a therapeutic target for colorectal cancer (CRC). ADAM12 expression in CRC cell lines, CRC tissues and a mouse model of peritoneal metastasis was assessed. The effect of ADAM12 on CRC EMT and metastasis was investigated using ADAM12-pcDNA6-myc and ADAM12-pGFP-C-shLenti constructs. ADAM12 overexpression enhanced the proliferation, migration, invasion and EMT of CRC cells. The phosphorylation levels of factors associated with the PI3K/Akt pathway were also increased by ADAM12 overexpression. The knockdown of ADAM12 reversed these effects. ADAM12 expression and the loss of E-cadherin expression were significantly associated with poorer survival compared with other expression statuses of both proteins. In a mouse model of peritoneal metastasis, overexpression of ADAM12 induced increased tumor weight and peritoneal carcinomatosis index compared with that in the negative control group. Conversely, knockdown of ADAM12 reversed these effects. Furthermore, E-cadherin expression was significantly decreased by overexpression of ADAM12 compared with in the negative control group. By contrast, E-cadherin expression was increased by knockdown of ADAM12 compared with in the negative control group. ADAM12 overexpression contributed to CRC metastasis by regulating EMT. In addition, in the mouse model of peritoneal metastasis, ADAM12 knockdown exhibited strong anti-metastatic action. Consequently, ADAM12 may be considered a therapeutic target for CRC metastasis.

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“…Colonoscopy is not only an effective method for the diagnosis, treatment, and follow-up of colorectal diseases, but it is also the preferred method for early colorectal cancer screening programs [1]. Most colorectal cancers are thought to develop from adenomatous polyps [2]. Endoscopic resection of colorectal adenomas can effectively reduce the morbidity and mortality rates associated with colorectal cancer [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Intestinal topical lidocaine spray improves the efficacy and safety of endoscopic sigmoid polypectomy

Lü¹,

Xiong²,

Wang

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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Background and aims Endoscopic polypectomy can prevent colorectal cancer. Adequate surgical field visualization is crucial to complete resection. To prevent visual field loss caused by intestinal peristalsis, we investigated the efficacy and safety of topical lidocaine spraying during the endoscopic sigmoid polypectomy (ESP). Methods Retrospective analysis was performed on 100 ESP patients admitted from July 2021 to October 2021, among which 50 patients received lidocaine (case group) and other 50 patients received normal saline (control group). Lidocaine or saline was sprayed on the colonic mucosa within 5 cm above and below the polyps before polypectomy. The en-bloc resection rate (EBRR) and complete resection rate (CRR) were primarily evaluated. Secondary outcomes included EBRR for polyps located in the 5–11 o’clock position, sigmoid colon peristalsis frequency, degree of exposure to the surgical field, operative times, and adverse events. Results There were no significant differences in the basic demographic characteristics between the two groups. EBRR and CRR in the case group were 72.9% and 95.8%, and in the control group were 53.3% and 91.1%, respectively. The EBRR of sigmoid polyps located at the 5–11 o’clock positions was significantly higher in the case group (82.8%) than in the control group (56.7%) (P = 0.03). Sigmoid colonic peristalsis was significantly inhibited after lidocaine spraying (P < 0.01). There was no statistical difference in the operative times and adverse event rates between the two groups. Conclusion Topical spraying lidocaine around polyps can safely and effectively reduce intestinal peristalsis, thus improving the EBRR of sigmoid polypectomy.

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Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer

Cited by 34 publications

References 136 publications

Association between diverticular disease and prevalence of colorectal adenomatous polyps or adenocarcinomas

Association between diverticular disease and prevalence of colorectal adenomatous polyps or adenocarcinomas

A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition

Intestinal topical lidocaine spray improves the efficacy and safety of endoscopic sigmoid polypectomy

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