Causative Pathogens, Antibiotic Sensitivity, Resistance Patterns, and Severity in a Contemporary Series of Fournier's Gangrene

Bjurlin, Marc A.; O'Grady, Thomas; Kim, Dae Y.; Divakaruni, Naveen; Drago, Andrew; Blumetti, Jennifer; Hollowell, Courtney M.P.

doi:10.1016/j.urology.2012.12.041

Cited by 56 publications

(32 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many studies have suggested the use of penicillin against Streptococci, metronidazole for anaerobes and third-generation cephalosporins against Staphylococci and Enterobacteriaceae. [22][23][24] In our study, Gram positive cocci like E. faecalis and S. aureus have shown highest susceptibility to linezolid and vancomycin. Enterobactericeae were highly susceptible to levofloxacin and piperacillintazobactam.…”

Section: Antimicrobial Susceptibility Patternsupporting

confidence: 48%

“…Broad-spectrum antibiotic treatment is suggested to adequately cover poly-microbial pathogens, and careful patient monitoring is required to avoid fungal or hospital acquired infection. [24] Proactive management of the diabetic and immunosuppressed patients with perineal infections is of extreme importance to prevent the development of FG. Weight reduction and avoidance of alcohol consumption and tobacco use may be helpful in reducing the possible risk of FG.…”

Section: Antimicrobial Susceptibility Patternmentioning

confidence: 99%

See 1 more Smart Citation

Fournier’s Gangrene: A Microbiological Overview

Gopi¹,

Vinoba²,

S³

et al. 2016

jemds

View full text Add to dashboard Cite

Fournier's gangrene (FG) is a rare, rapidly progressive, fulminant form of necrotizing fasciitis of the genital, perianal and perineal region and is usually secondary to polymicrobial infection. OBJECTIVESPresently, the literature regarding the spectrum of pathogens causing FG is limited. Hence, this study was undertaken to get a better understanding of (a) Microbial pathogens causing FG and (b) The clinical outcome. METHODSThe present study is a retrospective cohort study of the microbial pathogens isolated from FG patients admitted in a tertiary care centre. Data was collected from the hospital records of patients admitted with FG during June 2012 to November 2015. RESULTSA total of 55 male patients with FG were included in this study. The mean age of patient was 49.36 years. Out of 55 samples, 47-showed evidence of microbial growth, 12 samples showed mono-microbial and 35 samples showed poly-microbial growth. Among the cases included in the present study, anaerobic culture was requested for only 10 samples; 3 out of the 10 samples subjected to anaerobic culture yielded Bacteroides fragilis (B. fragilis). Klebsiella pneumoniae was the most common pathogen isolated (K. pneumoniae) (29/47, 61.70%), followed by Enterococcus faecalis (E. faecalis) (15/47, 31.91%), B. fragilis (3/10, 30%) and Escherichia coli (E. coli) (13/47, 27.65%). Gram negative organisms were highly susceptible to levofloxacin and piperacillintazobactam. Gram positive organisms were highly susceptible to linezolid (92%), vancomycin (84%) and tetracycline (68%). Major risk factors associated with FG were diabetes (43.6%) and obesity (40%). The mortality rate was 5.45%. CONCLUSIONFG is a rapidly progressive fulminant life threatening condition. Early diagnosis, aggressive surgical intervention and appropriate antimicrobial therapy may help to reduce the mortality rate.

show abstract

Section: Antimicrobial Susceptibility Patternsupporting

confidence: 48%

Section: Antimicrobial Susceptibility Patternmentioning

confidence: 99%

Fournier’s Gangrene: A Microbiological Overview

Gopi¹,

Vinoba²,

S³

et al. 2016

jemds

View full text Add to dashboard Cite

show abstract

“…Median debridement count was three (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Majority of the debridements were performed under spinoepidural anesthesia; however, twenty-seven patients (22.5%) required general anesthesia.…”

Section: Resultsmentioning

confidence: 99%

“…[1][2][3] These infections are typically polymicrobial, with both aerobic and anaerobic organisms present in the majority of cases. [3,4] In spite of the widely varying microorganisms in the etiology, its treatment is unique for all cases including emergency removal of the devitalized tissues, adequate resuscitation, and intravenous (iv) administration of wide-spectrum antibiotics. [1][2][3][4][5][6][7] spectively maintained departmental FG database.…”

Section: Introductionmentioning

confidence: 99%

“…[3,4] In spite of the widely varying microorganisms in the etiology, its treatment is unique for all cases including emergency removal of the devitalized tissues, adequate resuscitation, and intravenous (iv) administration of wide-spectrum antibiotics. [1][2][3][4][5][6][7] spectively maintained departmental FG database. Only adult patients admitted or referred to our department and diagnosed with FG were included in the study.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation