Causative and beneficial algae in human disease conditions: a review

Stein, Janet R.; Borden, Carol Ann

doi:10.2216/i0031-8884-23-4-485.1

Cited by 35 publications

(15 citation statements)

References 17 publications

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“…Thus these studies and those reported elsewhere (Larripa et al, 1987) on the nature of the biological activity in CDE of MP may provide a rational explanation for our earlier observations, as well as the efficacy of the long standing folk-medicinal use of brown algae for cancer treatment in China and Japan (Stein & Borden, 1984). The in vivo antitumor and in vitro cytotoxic effects initially observed (Mayer & Panick, 1982) may well be the result of a complex interaction of metals, algal polysaccharides and the physiological response of the host.…”

Section: Discussionsupporting

confidence: 84%

Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. I. Antitumor, cytotoxicity and humoral immune response

et al. 1987

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Section: Discussionsupporting

confidence: 84%

Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. I. Antitumor, cytotoxicity and humoral immune response

et al. 1987

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“…The absorption of relatively dilute concentrations of microcystins through intestinal, branchial, dermal or conjunctival routes, for example, may be limited in normal, healthy fish. However, cell lysates of M. aeruginosa contain a variety of toxic chemicals (Okino, Murakami, Haraguchi, Munekata, Matsuda & Yamaguchi 1993), and some, Uke phycocyanins, may be responsible for inflammatory reactions at mucosal and epithelial surfaces (Stein & Borden 1984). A moderate to severe inflammatory reaction may increase the permeability of mucosal and epithelial surfaces, which could eventually increase their permeability to microcystins and lead to a delayed onset of liver toxicity (Jubb, Kennedy & Palmer 1985).…”

Section: Discussionmentioning

confidence: 99%

The effects of microcystins on the serum biochemistry of carp, Cyprinus carpio L., when the toxins are administered by gavage, immersion and intraperitoneal routes

Carbis

Anderson

et al. 1996

Journal of Fish Diseases

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Microcystins were administered to carp, Cyprinus carpio L., by intraperitoneal injection. Tests performed on the serum indicated liver and gill damage, and disturbances in hepatic and osmoregulatory functions. Exposure of carp to microcystins by gavage and inrimersion caused changes indicating mild liver damage and changes in the equilibrium of cationanion balance in some treatments. The results of gavage and immersion exposure indicate that acute roxicity is unlikely to occur in wild carp populations, but chronic poisoning may follow repeated sublethal exposure. A serum biochemical profile comprising alanine amino transferase, aspartate amino transferase, bile acids, bilirubin, sodium and chloride determinations may provide a useful diagnostic indication of microcystin poisoning in wild carp populations.

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“…There are numerous reports on bioactive compounds in microalgae that have curative powers, particularly from tropical and subtropical species (Stein and Borden 1984;Metting and Pyne 1986;Cannell 1993). In contrast, limited screening programs have been conducted due to the scarcity of expertise in phycological research and industrial production.…”

Section: Introductionmentioning

confidence: 99%

Screening of Malaysian indigenous microalgae for antioxidant properties and nutritional value

et al. 2007

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Fourteen indigenous microalgal samples from Malaysia were isolated, purified and cultured from fresh, brackish and marine waters. The ability of the microalgae to be natural sources of antioxidants was studied by a screening test using three antioxidant chemical assays [ferric thiocyanate (FTC), thiobarbituric acid (TBA) and 1, 1'-diphenyl-2-picrylhydrazyl (DPPH)]. The results showed that six microalgal methanolic crude extracts (Isochrysis galbana, Chaetoceros calcitrans, Scenedesmus quadricauda, Chlorella vulgaris, Nannochloropsis oculata and Tetraselmis tetrathele) were active in inhibiting the lipid peroxidation of linoleic acid. Among all the microalgae, I. galbana and C. calcitrans showed the highest antioxidant activity (>90%) in FTC and TBA assays, indicating that these microalgae might contain active compounds for protection from lipid peroxidation. Nutritional analyses were performed on microalgae with high antioxidant activities (I. galbana and C. calcitrans) in order to investigate their nutritive value. Both microalgae were found to be rich in nutrients. For examples, I. galbana had average percentage composition of protein, carbohydrate, and lipid, as 47.9±2.5; 26.8±0.2; 14.5±1.4%, respectively, while the corresponding values for C. calcitrans were 36.4±

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Causative and beneficial algae in human disease conditions: a review

Cited by 35 publications

References 17 publications

Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. I. Antitumor, cytotoxicity and humoral immune response

Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. I. Antitumor, cytotoxicity and humoral immune response

The effects of microcystins on the serum biochemistry of carp, Cyprinus carpio L., when the toxins are administered by gavage, immersion and intraperitoneal routes

Screening of Malaysian indigenous microalgae for antioxidant properties and nutritional value

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