Causality assessment of serious neurologic adverse events following 2009 H1N1 vaccination

Williams, Sarah E.; Pahud, Barbara; Vellozzi, Claudia; Donofrio, Peter D.; Dekker, Cornelia L.; Halsey, Neal A.; Klein, Nicola P.; Baxter, Roger; Marchant, Colin D.; LaRussa, Philip; Barnett, Elizabeth D.; Tokars, Jerome I.; McGeeney, Brian E.; Sparks, Robert; Aukes, Laurie; Jakob, Kathleen; Coronel, Silvia; Sejvar, James J.; Slade, Barbara A.; Edwards, Kathryn M.

doi:10.1016/j.vaccine.2011.08.093

Cited by 51 publications

(37 citation statements)

References 22 publications

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“…According to a flow diagram depicting modified WHO causality assessment, her neurological event was considered to be "possibly" related to influenza vaccination (6). Among the reports of the neurological adverse effects associated with H1N1 vaccines occurring between October 1, 2009 and March 31, 2010 (6), Guillain-Barré syndrome (GBS) was the most frequent (79 cases; 37.3% of the total neurological adverse effects).…”

Section: Discussionmentioning

confidence: 99%

Acute Disseminated Encephalomyelitis Following 2009 H1N1 Influenza Vaccination

Maeda

Idehara

2012

Intern. Med.

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Since the worldwide spread of the novel influenza type A virus in 2009, trivalent vaccines against H1N1 (pandemic) 09 and seasonal influenza have been used. We describe a 33-year-old woman who presented with hypoesthesia below the Th7 level fifteen days after vaccination without any preceding infection. Cerebrospinal fluid showed an increased level of myelin basic protein and positive oligoclonal IgG bands. Magnetic resonance imaging revealed disseminated lesions in the brain and thoracic cord. Steroid therapy improved her symptoms. She was diagnosed as having acute disseminated encephalomyelitis (ADEM) possibly related to the vaccination. As a potential adverse effect of the influenza vaccine, in addition to Guillain-Barré syndrome, ADEM should also be recognized.

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Section: Discussionmentioning

confidence: 99%

Acute Disseminated Encephalomyelitis Following 2009 H1N1 Influenza Vaccination

Maeda

Idehara

2012

Intern. Med.

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“…Williams et al 14 assessed the causality of adverse events following influenza H1N1 vaccination. Their review 14 included a single case of cranial VI palsy 13 d after influenza H1N1 vaccine and trivalent seasonal influenza vaccine, in a 15-yold male who also had a history of headaches and sports-related concussions. Based on the time course and concomitant exposures, the authors 14 concluded that cranial neuropathy-including Bell's palsy and optic neuritis, as well as the case of abducens palsy-had a "possible" causal relationship with vaccination, according to modified World Health Organization criteria.…”

Section: Introductionmentioning

confidence: 99%

Motor palsies of cranial nerves (excluding VII) after vaccination

Woo

Winiecki

2013

Human Vaccines & Immunotherapeutics

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“…ADEM has been reported following measles, mumps, rubella, smallpox, hepatitis B, and IIV (6) . Severe neurological complications including ADEM associated with influenza vaccination have been sporadically reported from countries with a good surveillance system (7)(8) . Here, we report a case of ADEM following infl uenza vaccination that occurred in the western Brazilian Amazon.…”

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confidence: 99%