Causal relationship between ulcerative colitis and male infertility: A two-sample Mendelian randomization study
Xia Wang,
Tongyi Li,
Qiu Chen
Abstract:Aims
To explore the causal relationship between ulcerative colitis (UC) and male infertility using Mendelian randomization method with single nucleotide polymorphism (SNP) as the instrumental variables.
Methods
Genetic loci closely associated with UC were extracted as instrumental variables and male infertility was the outcome variable in pooled data from the gene-wide association study (GWAS),which was derived from European ethnic groups. The UC data(ebi-a-GCST003045) contained a total sample size of 27432 … Show more
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