Causal relationship between thyroid dysfunction and hallux valgus: A two-sample Mendelian randomization study

Xiong, Binglang; Bai, Zixing; Cao, Xuhan; Nie, Duorui; Zhang, Cheng; Sun, Xudong; Guo, Zhaoli; Wen, Jie; Sun, Weidong

doi:10.3389/fendo.2023.1115834

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…Our previous research indicated a significant correlation between low HGS and an increased risk of all‐cause mortality and cardiovascular mortality in the American population 7 . Furthermore, we have identified a causal relationship between HGS and all‐cause mortality based on a Genome‐wide association study analysis of a population of 1.1 million Europeans 8 . Additionally, HGS serves as a predictor of hip fracture recovery and is associated with falls and fractures in older adults 9,10 .…”

Section: Introductionmentioning

confidence: 86%

“…7 Furthermore, we have identified a causal relationship between HGS and allcause mortality based on a Genome-wide association study analysis of a population of 1.1 million Europeans. 8 Additionally, HGS serves as a predictor of hip fracture recovery and is associated with falls and fractures in older adults. 9,10 Dowling et al found that reduced muscle strength in elderly women with obesity in the UK significantly increases the risk of falls and fractures, particularly in the lower extremities.…”

Section: Introductionmentioning

confidence: 99%

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Association of Handgrip Strength with Hip Fracture and Falls in Community‐dwelling Middle‐aged and Older Adults: A 4‐Year Longitudinal Study

Guo,

Zhang,

Xiong

et al. 2024

Orthopaedic Surgery

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ObjectiveHip fracture and falls are significant health concerns. Handgrip strength (HGS) is closely associated with overall muscle strength and physical health. However, the longitudinal relationship between HGS and the risk of hip fractures and falls remains unclear, particularly regarding gender differences. This longitudinal study aimed to investigate the association between HGS and the risk of hip fracture and falls in individuals aged 45 years and above, considering gender‐specific differences over a 4‐year period.MethodsThis study included 10,092 participants (4471 men and 5621 women) aged 45 years and above from the China Health and Retirement Longitudinal Study (CHARLS). Incidents of hip fractures and falls were recorded during a 4‐year follow‐up, along with various demographic and clinical factors. Participants were categorized into five groups based on their HGS quintiles. Logistic regression models were employed to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) to assess the relationship between HGS and hip fracture/fall risk.ResultsDuring the 4‐year follow‐up period, 223 cases of hip fracture (2.2%) and 1831 cases of falls (18.1%) were documented. Notably, higher HGS demonstrated a strong inverse association with the risk of hip fracture in both males and females (p < 0.05). In comparison to the lowest HGS quintile, the adjusted odds ratios (ORs) for hip fracture were 0.46 (0.27–0.78) for the total population, 0.4 (0.19–0.81) for males and 0.48 (0.23–0.98) for females in the highest HGS quintile. Furthermore, a profound and statistically significant negative correlation between HGS and falls was detected (p < 0.05). The adjusted ORs for falls in the highest HGS quintile, compared to the lowest quintile, were 0.62 (0.51–0.76) in the overall population, 0.59 (0.44–0.78) in males, and 0.78 (0.62–0.99) in females.ConclusionOur findings highlight the significant inverse association between HGS and the risk of hip fracture and falls in both males and females aged 45 years and above. Assessing handgrip strength may serve as a valuable tool for predicting fracture and fall risk.

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Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Association of Handgrip Strength with Hip Fracture and Falls in Community‐dwelling Middle‐aged and Older Adults: A 4‐Year Longitudinal Study

Guo,

Zhang,

Xiong

et al. 2024

Orthopaedic Surgery

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Inflammatory bowel disease and breast cancer: A two-sample bidirectional Mendelian randomization study

Guo,

Xu,

Fang

et al. 2024

Medicine

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There is a correlation between IBD and breast cancer according to previous observational studies. However, so far there is no evidence to support if there is a causal relationship between these 2 diseases. We acquired comprehensive Genome-Wide Association Study (GWAS) summary data on IBD (including ulcerative colitis [UC] and Crohn disease [CD]) as well as breast cancer of completely European descent from the IEU GWAS database. The estimation of bidirectional causality between IBD (including UC and CD) and breast cancer was achieved through the utilization of 2-sample Mendelian randomization (MR). The MR results were also assessed for any potential bias caused by heterogeneity and pleiotropy through sensitivity analyses. Our study found a bidirectional causal effect between IBD and breast cancer. Genetic susceptibility to IBD was associated with an increased risk of breast cancer (OR = 1.053, 95% CI: 1.016–1.090, P = .004). Similarly, the presence of breast cancer may increase the risk of IBD (OR = 1.111, 95% CI: 1.035–1.194, P = .004). Moreover, the bidirectional causal effect between IBD and breast cancer can be confirmed by another GWAS of IBD. Subtype analysis showed that CD was associated with breast cancer (OR = 1.050, 95% CI: 1.020–1.080, P < .001), but not UC and breast cancer. There was a suggestive association between breast cancer and UC (OR = 1.106, 95% CI: 1.011–1.209, P = .028), but not with CD. This study supports a bidirectional causal effect between IBD and breast cancer. There appear to be considerable differences in the specific associations of UC and CD with AD. Understanding that IBD including its specific subtypes and breast cancer constitute common risk factors can contribute to the clinical management of both diseases.

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Causal relationship between hypothyroidism and temporomandibular disorders: evidence from complementary genetic methods

Chen,

Xu,

Cheng

et al. 2024

BMC Oral Health

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Background The role of thyroid health in temporomandibular disorders (TMDs) has been emphasized in observational studies. However, whether the causation exists is unclear, and controversy remains about which specific disorder, such as hypothyroidism or hyperthyroidism, is destructive in TMDs. This study aims to investigate the overall and specific causal effects of various thyroid conditions on TMDs. Methods Mendelian randomization (MR) studies were performed using genetic instruments for thyrotropin (TSH, N = 119,715), free thyroxine (fT4, N = 49,269), hypothyroidism (N = 410,141), hyperthyroidism (N = 460,499), and TMDs (N = 211,023). We assessed the overall effect of each thyroid factor via inverse-variance weighted (IVW), weighted median, and MR-Egger methods, and performed extensive sensitivity analyses. Additionally, multivariable MR was conducted to evaluate the direct or indirect effects of hypothyroidism on TMDs whilst accounting for TSH, fT4 and hyperthyroidism, and vice versa. Results Univariable MR analyses revealed a causal effect of hypothyroidism on an increased risk of TMDs (IVW OR: 1.12, 95% CI: 1.05–1.20, p = 0.001). No significant association between genetically predicted hyperthyroidism, TSH, or fT4 and TMDs. In the multivariable MR analyses, the effects of hypothyroidism on TMDs occurrence remained significant even after adjSusting for TSH, fT4 and hyperthyroidism (multivariable IVW OR: 1.10, 95% CI: 1.03–1.17, p = 0.006). No pleiotropy and heterogeneity were detected in the analyses (p > 0.05). Conclusions Hypothyroidism might causally increase the risk of TMDs through a direct pathway, highlighting the critical role of managing thyroid health in the prevention of TMDs. Clinicians should give heightened attention to patients with hypothyroidism when seeking medical advice for temporomandibular discomfort. However, caution is warranted due to the potential confounders, pleiotropy, and selection bias in the MR study.

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Causal relationship between thyroid dysfunction and hallux valgus: A two-sample Mendelian randomization study

Cited by 3 publications

References 49 publications

Association of Handgrip Strength with Hip Fracture and Falls in Community‐dwelling Middle‐aged and Older Adults: A 4‐Year Longitudinal Study

Association of Handgrip Strength with Hip Fracture and Falls in Community‐dwelling Middle‐aged and Older Adults: A 4‐Year Longitudinal Study

Inflammatory bowel disease and breast cancer: A two-sample bidirectional Mendelian randomization study

Causal relationship between hypothyroidism and temporomandibular disorders: evidence from complementary genetic methods

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