Causal relationship between the gut microbiota, immune cells, and coronary heart disease: a mediated Mendelian randomization analysis
Feifei Yang,
Hui Song,
Weizhi Tang
et al.
Abstract:BackgroundRecent studies have shown that the gut microbiota (GM), immune cells, and coronary heart disease (CHD) are closely related, but the causal nature of these relationships is largely unknown. This study aimed to investigate this causal relationship and reveal the effect of GM and immune cells on the risk of developing CHD using mediated Mendelian randomization (MR) analysis.MethodsFirst, we searched for data related to GM, immune cells, and CHD through published genome-wide association studies (GWAS). W… Show more
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