Causal relationship between telomere length and osteonecrosis: Bidirectional two-sample Mendelian randomization analysis
Hao Liu,
Wei Yan,
Jinsong Li
et al.
Abstract:Recent mounting evidence suggests that shortening of telomere length (TL) is associated with impaired bone health; yet, a genetic causal relationship between TL and osteonecrosis remains uncertain. This study aimed to investigate the potential causal relationship between TL and osteonecrosis using bidirectional two-sample Mendelian randomization (MR). Genome-wide association study summary statistics for TL were sourced from the IEU Open genome-wide association study project, while osteonecrosis data were obtai… Show more
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