Causal relationship between serum uric acid and cardiovascular disease: a Mendelian randomization study
yu jun zhang,
Qiufang Lian,
Yanwu Nie
et al.
Abstract:Observational studies have established an association between serum uric acid and cardiovascular disease (CVD). However, these studies are susceptible to uncontrolled confounders and reverse causality bias, leading to ambiguity in the causal relationship. To overcome these challenges, our study employed a two-sample Mendelian randomization approach to investigate the causal link between serum uric acid and CVD. The data on serum uric acid and seven cardiovascular diseases are sourced from the IEU Open GWAS dat… Show more
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