Causal relationship between gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study

Yan, Shuxiang; Wang, Hua; Feng, Baiyu; Ye, Lin; Chen, Anqun

doi:10.3389/fimmu.2024.1332757

Cited by 2 publications

References 70 publications

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No Causal Association Between Gut Microbiota and Kawasaki Disease: A Two-Sample Mendelian Randomization Study

Wang,

Luo,

et al. 2024

Preprint

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Background: Despite previous observational studies linking gut microbiota to Kawasaki disease (KD), these findings remain controversial. This study aimed to explore the association between gut microbiota and KD at a genetic level, using a two-sample Mendelian randomization (MR) analysis. Methods: A two-sample MR study utilized summary statistics of gut microbiota from the largest genome-wide association study meta-analysis by the MiBioGen consortium. The causal link between gut microbiota and KD was examined using inverse variance weighted, MR Egger, weighted median, simple mode, weighted mode, and MR-PRESSO methods. Reverse MR analysis was conducted on bacteria identified as causally linked to KD in the initial MR study. Cochran’s Q and Rucker’s Q statistics quantified the heterogeneity among instrumental variables. Results: Inverse variance weighted estimates suggested no genetic causal correlation with KD for the following taxa: genus Bifidobacterium(p = 0.774, OR 95% CI = 0.876 [0.355–2.163]), genus FamilyXIIIAD3011group(p = 0.945, OR 95% CI = 0.979 [0.539–1.780]), genus LachnospiraceaeUCG004(p = 0.987, OR 95%CI = 1.005 [0.542–1.863]), genus RuminococcaceaeNK4A214group (p = 0.453, OR 95%CI = 1.469 [0.538–4.009]), genus RuminococcaceaeUCG002 (p = 0.835, OR 95% CI = 1.092 [0.478–2.494]), genus LachnospiraceaeUCG001 (p = 0.996, OR 95%CI = 0.998 [0.482–2.066]), genus Bacteroides (p = 0.595, OR 95%CI = 0.831 [0.419–1.648]), genus Olsenella (p = 0.414, OR 95%CI = 1.312 [0.684–2.516]), genus Lactococcus (p = 0.870, OR 95%CI = 0.962 [0.600–1.541]), family Rhodospirillaceae (p = 0.995, OR 95%CI = 1.002 [0.550–1.827]), family FamilyXIII (p = 0.894, OR 95%CI = 1.093 [0.298–4.009]), family BacteroidalesS24 (p = 0.604, OR 95%CI = 0.849 [0.456–1.578]), family Ruminococcaceae (p = 0.524, OR 95%CI = 0.692 [0.223–2.148]), and class Bacilli (p = 0.905, OR 95%CI = 0.967 [0.561–1.667]). The reverse MR analysis revealed no significant causal effect of KD on gut microbiota. No significant heterogeneity of instrumental variables or horizontal pleiotropy was observed. Conclusion: Our bidirectional causal inference analysis revealed no genetic causal relationship between gut microbiota and KD. Confounding factors might have influenced the observed association in observational studies. Further research requires more advanced MR analysis methods, and larger-scale GWAS datasets.

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No Causal Association Between Gut Microbiota and Kawasaki Disease: A Two-Sample Mendelian Randomization Study

Wang,

Luo,

et al. 2024

Preprint

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Gut Microbiome Differences Regarding Lifestyle and the History of COVID-19 Disease in Ulcerative Colitis Patients

Straume,

Krūmiņa,

Elbere

et al. 2024

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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The microbiome’s role in ulcerative colitis pathogenesis is established. The influence of lifestyle on gut microbiome composition remains unclear, and interplay with COVID-19 disease warrants investigation. In a cross-sectional study conducted from June to December 2021, 49 outpatients from Rīga East Clinical University Hospital were included. Patients were categorised based on COVID-19 disease status (positive vs. negative) within the preceding six months. Lifestyle factors (smoking, alcohol consumption, physical activity, stress levels, and dietary patterns) were assessed and evaluated. Taxonomic classification of gut microbiome metagenome data was performed using MetaPhlAn v.2.6.0, with subsequent analysis conducted using SPSS 20.0. Thirty-one (63%) were male, and 18 (37%) were female patients. Fourteen patients (28.6%) tested positive for COVID-19. Gut microbiome composition differences were not observed between COVID-19 disease groups. Twenty-four (49%) patients engaged in sports activities and 30 (61.2%) patients reported a history of smoking. No significant microbiome differences were observed in groups regarding physical activity or smoking. Thirty-five (71.4%) were alcohol users, for whom Firmicutes abundance was significantly higher compared to non-users, p = 0.041. Patients reporting lower stress levels (18, 36.7%) exhibited higher Actinobacteria abundance compared to those with higher stress levels (31, 63.3%), p = 0.03. COVID-19 disease status did not affect gut microbiome composition, alcohol consumption and stress levels demonstrated significant associations.

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Causal relationship between gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study

Cited by 2 publications

References 70 publications

No Causal Association Between Gut Microbiota and Kawasaki Disease: A Two-Sample Mendelian Randomization Study

No Causal Association Between Gut Microbiota and Kawasaki Disease: A Two-Sample Mendelian Randomization Study

Gut Microbiome Differences Regarding Lifestyle and the History of COVID-19 Disease in Ulcerative Colitis Patients

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