Causal Mechanisms of Subjective Cognitive Dysfunction in Schizophrenic and Depressed Patients

Bosch, van den Robert; Rombouts, R.

doi:10.1097/00005053-199806000-00007

Cited by 34 publications

(11 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our interpretation of the regression analyses is that the CAI Patient rating alone provided a good deal of information for predicting cognitive functioning, functional capacity, and social functioning. In contrast to prior work suggesting that patient selfreport measures lack validity with respect to relationships with objective neurocognitive test scores or real-world outcomes, the findings reported here suggest that the CAI does provide reliable and meaningful information about the patient’s functioning (van den Bosch and Rombouts 1998; Stip, Caron et al 2003; Moritz, Ferahli et al 2004; Prouteau, Verdoux et al 2004). …”

Section: Discussioncontrasting

confidence: 99%

“…However, for the data collected by a PRO to be meaningful, there should be empirical evidence that the PRO instrument effectively measures the particular construct being studied. Because ratings generated by patient self-report alone are correlated weakly or not at all with neurocognitive functioning in schizophrenia (van den Bosch and Rombouts 1998; Stip, Caron et al 2003; Moritz, Ferahli et al 2004; Prouteau, Verdoux et al 2004; Hofer, Niedermayer et al 2007), interview-based measures of cognition that are conducted by trained raters might be needed to provide reliable and valid information.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Cognitive Assessment Interview (CAI): Development and validation of an empirically derived, brief interview-based measure of cognition

Ventura¹,

Reise

Keefe

et al. 2010

Schizophrenia Research

View full text Add to dashboard Cite

Background Practical, reliable “real world” measures of cognition are needed to supplement neurocognitive performance data to evaluate possible efficacy of new drugs targeting cognitive deficits associated with schizophrenia. Because interview-based measures of cognition offer one possible approach, data from the MATRICS initiative (n=176) were used to examine the psychometric properties of the Schizophrenia Cognition Rating Scale (SCoRS) and the Clinical Global Impression of Cognition in Schizophrenia (CGI-CogS). Method We used classical test theory methods and item response theory to derive the 10 item Cognitive Assessment Interview (CAI) from the SCoRS and CGI-Cogs (“parent instruments”). Sources of information for CAI ratings included the patient and an informant. Validity analyses examined the relationship between the CAI and objective measures of cognitive functioning, intermediate measures of cognition, and functional outcome. Results The rater’s score from the newly derived CAI (10-items) correlate highly (r = .87) with those from the combined set of the SCoRS and CGI-CogS (41 items). Both the patient (r= .82) and the informant (r= .95) data were highly correlated with the rater’s score. The CAI was modestly correlated with objectively measured neurocognition (r = −.32), functional capacity (r = −.44), and functional outcome (r = −.32), which was comparable to the parent instruments. Conclusions The CAI allows for expert judgment in evaluating a patient’s cognitive functioning and was modestly correlated with neurocognitive functioning, functional capacity, and functional outcome. The CAI is a brief, repeatable, and potentially valuable tool for rating cognition in schizophrenia patients who are participating in clinical trials.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Cognitive Assessment Interview (CAI): Development and validation of an empirically derived, brief interview-based measure of cognition

Ventura¹,

Reise

Keefe

et al. 2010

Schizophrenia Research

View full text Add to dashboard Cite

show abstract

“…Indeed Cuesta et al (1996) did find that female patients had significantly higher complaint scores on the FCQ, however it must be noted that there were only six females from a small sample of just 32 patients. Similar under representation of females is seen in most of the other studies in this review, with only van den Bosch and Rombouts (1998) having an equal number of males and females in their study.…”

Section: Limitationssupporting

confidence: 83%

Subjective and Objective Cognitive Dysfunction in Schizophrenia – is there a Link?

Homayoun¹,

Nadeau-Marcotte²,

Luck³

et al. 2011

Front. Psychology

View full text Add to dashboard Cite

Cognitive dysfunction is a well recognized symptom of schizophrenia, as well as patients having poor insight into their illness. The subjective scale to investigate cognition in schizophrenia (SSTICS) is one of several scales that have been developed to study subjective cognitive dysfunction and has been compared to patients’ objective cognitive level. A literature search was performed using PubMed, psychINFO, Web of Science, and cross-referencing to find 26 articles which used 14 different subjective cognitive dysfunction scales to investigate the relationship between subjective and objective measures of cognition in schizophrenia. Although the majority of studies using the SSTICS found significant correlations between subjective and objective measures of cognition, the findings from the other scales were less clear. From this review, the issue of whether or not schizophrenic patients have good cognitive insight remains unsure. However, due to the heterogeneous nature of the study designs and their outcome measures, continued work in this area with consistency on these points is necessary; on the path to better provide management options for a very debilitating component of this illness.

show abstract

“…Patients with psychotic symptoms, such as hallucinations or delusions, may also have similar impairments, which may lead to situations conducive to TBI. [35][36][37][38] We also found that acute reaction to stress or adjustment reaction, malaise or fatigue, and somatoform disorders may lead to increased risk of TBI. These diagnoses may be proxies for general psychiatric distress, including depression and anxiety, that are modifiable risk factors for TBI.…”

Section: Discussionmentioning

confidence: 75%

Psychiatric illness and subsequent traumatic brain injury: a case control study

Fann

2002

Journal of Neurology, Neurosurgery &Amp; Psychiatry

View full text Add to dashboard Cite

Objective: To determine whether psychiatric illness is a risk factor for subsequent traumatic brain injury (TBI). Methods: Case control study in a large staff model health maintenance organisation in western Washington State. Patients with TBI, determined by International classification of diseases, 9th revision, clinical modification (ICD-9-CM) diagnoses, were 1440 health plan members who had TBI diagnosed in 1993 and who had been enrolled in the previous year, during which no TBI was ascertained. Three health plan members were randomly selected as control subjects, matched by age, sex, and reference date. Psychiatric illness in the year before the TBI reference date was determined by using computerised records of ICD-9-CM diagnoses, psychiatric medication prescriptions, and utilisation of a psychiatric service. Results: For those with a psychiatric diagnosis in the year before the reference date, the adjusted relative risk for TBI was 1.7 (95% confidence interval (CI) 1.4 to 2.0) compared with those without a psychiatric diagnosis. Patients who had filled a psychiatric medication prescription had an adjusted relative risk for TBI of 1.6 (95% CI 1.2 to 2.1) compared with those who had not filled a psychiatric medication prescription. Patients who had utilised psychiatric services had an adjusted relative risk for TBI of 1.3 (95% CI 1.0 to 1.6) compared with those who had not utilised psychiatric services. The adjusted relative risk for TBI for patients with psychiatric illness determined by any of the three psychiatric indicators was 1.6 (95% CI 1.4 to 1.9) compared with those without any psychiatric indicator. Conclusion: Psychiatric illness appears to be associated with an increased risk for TBI.T he most common mechanisms of traumatic brain injury (TBI) are motor vehicle collisions, falls, sports and recreational injuries, and assaults.1-5 The known risk factors for sustaining a TBI are age 15-24 years (with smaller peaks in the > 60 and < 5 year age groups), male sex, increased blood alcohol concentration, and lower socioeconomic status.6 7 The identification of modifiable risk factors and of high risk populations has recently been prioritised by the Department of Health and Human Services' Interagency Head Injury Task Force in the United States 8 and may lead to prevention programs that help to decrease the incidence of TBI and associated disability and mortality. Although mild cases constitute the vast majority of TBI and may result in prolonged disability, 9 relatively little is known about the risk factors for mild TBI.While it is recognised that people are more likely to suffer from psychiatric illness following TBI, 10 it is less clear whether those who sustain a TBI are more likely to have had a psychiatric illness before their injury. Previous studies suggest that psychiatric illness may be a risk factor for traumatic accidents but they did not specifically examine TBI as an outcome. [11][12][13][14][15][16][17] Furthermore, some of these studies examined small or selected populations and ascertaine...

show abstract

Causal Mechanisms of Subjective Cognitive Dysfunction in Schizophrenic and Depressed Patients

Cited by 34 publications

References 14 publications

The Cognitive Assessment Interview (CAI): Development and validation of an empirically derived, brief interview-based measure of cognition

The Cognitive Assessment Interview (CAI): Development and validation of an empirically derived, brief interview-based measure of cognition

Subjective and Objective Cognitive Dysfunction in Schizophrenia – is there a Link?

Psychiatric illness and subsequent traumatic brain injury: a case control study

Contact Info

Product

Resources

About