Causal factors for osteoarthritis risk revealed by mendelian randomization analysis
Qingfeng Luo,
Shiyong Zhang,
Qiyuan Yang
et al.
Abstract:Osteoarthritis (OA), a prevalent chronic disease among the elderly, presents a complex pathogenesis and currently lacks effective treatment. Traditional observational studies are time-consuming, labor-intensive, susceptible to confounding factors, and cannot establish causal relationships. Mendelian randomization (MR) analysis, leveraging genetic variation to assess causal associations between exposures and outcomes, offers a cost-effective and efficient alternative. Over the past decade, large-scale genome-wi… Show more
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