Causal evidence for task-specific involvement of the dorsomedial prefrontal cortex in human social cognition

Martin, Andrew K.; Dzafic, Ilvana; Ramdave, Swathi; Meinzer, Marcus

doi:10.1093/scan/nsx063

Cited by 57 publications

(55 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The visual perspective taking (VPT) task has been described in detail previously (Martin, Dzafic, et al, 2017;Martin, Huang, et al, 2018;Martin et al, 2019). In brief, three separate tests were administered measuring implicit, explicit level one and explicit level two.…”

Section: Visual Perspective Taking Taskmentioning

confidence: 99%

“…The main outcome of interest was the congruency effect (incongruentcongruent) for both egocentric and allocentric conditions. The avatar and traffic light factor was only of interest in the implicit VPT task and was collapsed across for the explicit tasks, similar to previous studies (Martin, Dzafic, et al, 2017;Martin, Huang, et al, 2018;Martin et al, 2019;Santiesteban, Catmur, Hopkins, Bird, & Heyes, 2014).…”

Section: Visual Perspective Taking Taskmentioning

confidence: 99%

“…2016). Recently, we have demonstrated that high-definition transcranial direct current stimulation (HD-tDCS) to the dmPFC and rTPJ, can produce regional and task specific effects on self-other processes (Martin, Dzafic, Ramdave, & Meinzer, 2017;Martin, Huang, Hunold, & Meinzer, 2018). Excitatory stimulation to the dmPFC increased the integration of the other (allocentric) perspective into the self (egocentric) perspective across explicit VPT tasks and removed the SRE in episodic memory.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Common and unique effects of HD-tDCS to the social brain across cultural groups

Martin

Meinzer

2018

Preprint

View full text Add to dashboard Cite

Total words: 5105Culture and social brain stimulation effects ABSTRACT Cultural background influences social cognition, however no study has examined brain stimulation differences attributable to cultural background. 104 young adults [52 South-East Asian Singaporeans (SEA); 52 Caucasian Australians (CA)] received anodal high-definition transcranial direct current stimulation (HD-tDCS) to the dorsomedial prefrontal cortex (dmPFC) or the right temporoparietal junction (rTPJ). Participants completed tasks with varying demands on self-other processing including visual perspective taking and episodic memory with self and other encoding. At baseline, SEA showed greater self-other integration than CA in the level one (line-of-sight) VPT task as indexed by greater interference from the alternate perspective. Anodal HD-tDCS to the dmPFC resulted in the CA performing closer to the SEA during egocentric perspective judgements. Baseline performance on level two (embodied rotation) VPT task and the self-reference effect in memory (SRE) was comparable between the two groups. In the combined sample, HD-tDCS to the rTPJ decreased the interference from the egocentric perspective during level two VPT and dmPFC HD-tDCS removed the SRE in episodic memory. Stimulation effects were comparable when baseline performance was comparable. When baseline performance differed, stimulation differences were identified. Therefore, social cognitive differences due to cultural background are an important consideration in social brain stimulation studies.

show abstract

Section: Visual Perspective Taking Taskmentioning

confidence: 99%

Section: Visual Perspective Taking Taskmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Common and unique effects of HD-tDCS to the social brain across cultural groups

Martin

Meinzer

2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Inconsistencies are also seen in results from three quantitative meta-analyses examining neural 22 responses to social exclusion across paradigms. The following ACC subregions were associated with 23 social exclusion across meta-analyses: (1) rostral perigenual ACC bordering on mPFC (Cacioppo et al,24 2013), (2) perigenual and subgenual ACC (Vijayakumar et al, 2017); and (3) vACC and anterior dACC 25 (Rotge et al, 2015). In comparison, the ventromedial PFC, ventrolateral PFC/lateral OFC, and anterior 26 insula were more reliably recruited than ACC subregions across whole-brain meta-analyses (Cacioppo et 1 al., 2013;Vijayakumar et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Feeling left out or just surprised? Neural correlates of social exclusion and over-inclusion in adolescence

Cheng

Vijayakumar

Flournoy

et al. 2019

Preprint

View full text Add to dashboard Cite

1Social belonging and affiliation are important human drives that impact decision-making and 2 health outcomes. While neural responses to social exclusion are increasingly well-characterized, studies 3 rarely identify whether these responses reflect the affective distress or expectancy violation associated 4 with exclusion. The present study compares neural responses to exclusion and over-inclusion, a similarly 5 unexpected social occurrence that violates fair play expectations, but does not involve rejection, with a 6 focus on implications for models of dorsal anterior cingulate cortex (dACC) function. In an fMRI 7 adaptation of the Cyberball paradigm with human adolescents 11.1-17.7 years of age (N=69), we 8 employed parametric modulators to examine scaling of neural signal with cumulative exclusion and 9 inclusion events. The use of parametric modulators overcomes arbitrary definitions of condition onsets 10 and offsets imposed on fluid, continuous gameplay. In support of the notion that the dACC plays a role in 11 processing affective distress, this region exhibited greater signal with cumulative exclusion than 12 cumulative inclusion events. However, this difference was partly driven by diminished signal 13 accompanying cumulative inclusion, a finding that does not conform to either affective distress or 14 expectancy violation model predictions. Additionally, we found that signal in the insula and dorsomedial 15 prefrontal cortex scaled uniquely with social exclusion and over-inclusion, respectively, while 16 conjunction analyses revealed that the rostromedial prefrontal cortex and left intraparietal sulcus 17 responded similarly to both conditions. These findings shed light on which neural regions may exhibit 18 patterns of differential sensitivity to exclusion or over-inclusion, as well as those that are more broadly 19 engaged by both types of social interaction. 20 21 Keywords: Cyberball, social exclusion, functional MRI, anterior cingulate cortex 22 23 24 25 26

show abstract

“…Non-invasive brain stimulation techniques, such as tDCS, have a direct effect on brain activity in comparison to neurofeedback techniques (Luft et al, 2014). Techniques such as tDCS are able to affect social cognition (Martin et al, 2017) and could have significant potential to improve cognitive outcomes in patients with serious mental health issues (Baeken et al, 2016;Tortella et al, 2015).…”

Section: Implications Of Findingsmentioning

confidence: 99%

The neuroimaging and genetics of emotion perception in schizophrenia

Dzafic¹

Self Cite

View full text Add to dashboard Cite

Impaired emotion perception is a core deficit in schizophrenia (SCZ) that is robustly associated with poor functional outcome. Studies to date have failed to delineate the critical cognitive, neural and genetic factors that underlie 'naturalistic' emotion perception deficits in SCZ. Recently it has been proposed that in SCZ reduced precision in prior expectations impairs perception. Normal perception relies on predictive processing from precise prior expectations, which prioritise attention to context-relevant stimuli. However, no studies to date have explored the aberrancy of prior expectations during naturalistic emotion perception in SCZ and the underlying abnormal neural circuitry or involvement of SCZ genes. The present thesis aims to develop a novel dynamic emotion perception (DEP) task, in order to examine (1) the influence of prior expectations on naturalistic emotion perception in healthy individuals, and (2) emotion perception impairment in SCZ by investigating aberrancy in prior expectations, neural circuitry, and genetics.The aim of Study 1 was to create a novel functional magnetic resonance imaging (fMRI) paradigm to examine the mechanisms of prior expectations and delineate the spatiotemporal activity of brain regions that contribute to emotion perception. The newly developed and validated fMRI DEP task has improved ecological validity, using dynamic, audio-visual videos, instead of static pictures as stimuli. The improved method provided new behavioural and neuroimaging insights into the influence of prior expectations on naturalistic emotion perception. Prior expectations facilitated emotion perception after repeated exposure and learning over the course of the experiment, engaging prefrontal regions and right amygdala. In contrast, emotions incongruent with prior expectations engaged neural correlates of automatic change detection, which in a complex dynamic environment allows for adaptive behaviours in potentially advantageous or threatening situations.In Study 2, the DEP task was utilised to delineate, in the healthy brain, the functional networks that subserve rapid recognition of threatening emotions in situations either congruent or incongruent with prior expectations. The results showed that fast detection of threat congruent with prior expectations engaged a right amygdala subcortical network, which has been previously implicated in fear conditioning and coarse processing of emotion. In contrast, there was a trend association between fast detection of threat incongruent with prior expectations and activity in inferior frontoparietal network connected to the right temporoparietal junction; this has been previously implicated in rapid reorienting of attention to Finally, in Study 4, the association between SCZ polygenic risk score (PRS) and brain activity during the DEP task in healthy adults was investigated in order to assess emotion perception as an endophenotype for SCZ. The results demonstrate that PRS is associated with higher recruitment of regions involved in emotion regulat...

show abstract

Causal evidence for task-specific involvement of the dorsomedial prefrontal cortex in human social cognition

Cited by 57 publications

References 63 publications

Common and unique effects of HD-tDCS to the social brain across cultural groups

Common and unique effects of HD-tDCS to the social brain across cultural groups

Feeling left out or just surprised? Neural correlates of social exclusion and over-inclusion in adolescence

The neuroimaging and genetics of emotion perception in schizophrenia

Contact Info

Product

Resources

About