Causal effects of gut microbiota on multiple sclerosis: A two‐sample Mendelian randomization study
Dongren Sun,
Yangyang Zhang,
Rui Wang
et al.
Abstract:BackgroundGut microbiota alterations in multiple sclerosis (MS) patients have been reported in observational studies, but whether these associations are causal is unclear.ObjectiveWe performed a Mendelian randomization study (MR) to assess the causal effects of gut microbiota on MS.MethodsIndependent genetic variants associated with 211 gut microbiota phenotypes were selected as instrumental variables from the largest genome‐wide association studies (GWAS) previously published by the MiBioGen study. GWAS data … Show more
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