Causal Effects between Gut Microbiome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Two-Sample Mendelian Randomization Study

He, Gang; Cao, Yu; Ma, Honghao; Guo, S. J.; Xu, Wangzi; Wang, Dai; Yongquan, Chen; Hou-zhao, Wang

doi:10.3389/fmicb.2023.1190894

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…Interestingly, a large proportion of ME/CFS patients (35 to 90%) have gastrointestinal complaints, which are often associated with the comorbidities IBS and IBD ( 34 ). Various studies have demonstrated intestinal dysbiosis in ME/CFS ( Table 1 ) ( 13 , 33 , 34 , 36 – 44 ), although uniform microbiome signatures are non-existent. This is mainly due to the high intra- and inter-individual variability of the microbiome.…”

Section: Intestinal Dysbiosis In Me/cfsmentioning

confidence: 99%

The gastrointestinal microbiota in the development of ME/CFS: a critical view and potential perspectives

Stallmach,

Quickert,

Puta

et al. 2024

Front. Immunol.

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Like other infections, a SARS-CoV-2 infection can also trigger Post-Acute Infection Syndromes (PAIS), which often progress into myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS, characterized by post-exercise malaise (PEM), is a severe multisystemic disease for which specific diagnostic markers or therapeutic concepts have not been established. Despite numerous indications of post-infectious neurological, immunological, endocrinal, and metabolic deviations, the exact causes and pathophysiology remain unclear. To date, there is a paucity of data, that changes in the composition and function of the gastrointestinal microbiota have emerged as a potential influencing variable associated with immunological and inflammatory pathways, shifts in ME/CFS. It is postulated that this dysbiosis may lead to intestinal barrier dysfunction, translocation of microbial components with increased oxidative stress, and the development or progression of ME/CFS. In this review, we detailed discuss the findings regarding alterations in the gastrointestinal microbiota and its microbial mediators in ME/CFS. When viewed critically, there is currently no evidence indicating causality between changes in the microbiota and the development of ME/CFS. Most studies describe associations within poorly defined patient populations, often combining various clinical presentations, such as irritable bowel syndrome and fatigue associated with ME/CFS. Nevertheless, drawing on analogies with other gastrointestinal diseases, there is potential to develop strategies aimed at modulating the gut microbiota and/or its metabolites as potential treatments for ME/CFS and other PAIS. These strategies should be further investigated in clinical trials.

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Section: Intestinal Dysbiosis In Me/cfsmentioning

confidence: 99%

The gastrointestinal microbiota in the development of ME/CFS: a critical view and potential perspectives

Stallmach,

Quickert,

Puta

et al. 2024

Front. Immunol.

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“…The relationship between host genetic factors and the gut microbiome in the context of BTC necessitates more comprehensive exploration. Mendelian Randomization (MR), a prevalent analytical technique employed for investigating causal linkages between exposure variables and resultant outcomes, has been utilized to probe prospective causal affiliations between gut microbiota and a diverse array of medical conditions (Liu et al, 2023;Xi et al, 2023;Min et al, 2023;He et al, 2023;Li et al, 2023;Luo et al, 2023b). Consequently, we endeavored to ascertain the causal linkage between these variables at the genetic level through the application of MR techniques.…”

Section: Introductionmentioning

confidence: 99%

The causal relationship between gut microbiota and biliary tract cancer: comprehensive bidirectional Mendelian randomization analysis

Wang,

Qin

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundGrowing evidence has shown that gut microbiome composition is associated with Biliary tract cancer (BTC), but the causality remains unknown. This study aimed to explore the causal relationship between gut microbiota and BTC, conduct an appraisal of the gut microbiome’s utility in facilitating the early diagnosis of BTC.MethodsWe acquired the summary data for Genome-wide Association Studies (GWAS) pertaining to BTC (418 cases and 159,201 controls) from the Biobank Japan (BBJ) database. Additionally, the GWAS summary data relevant to gut microbiota (N = 18,340) were sourced from the MiBioGen consortium. The primary methodology employed for the analysis consisted of Inverse Variance Weighting (IVW). Evaluations for sensitivity were carried out through the utilization of multiple statistical techniques, encompassing Cochrane’s Q test, the MR-Egger intercept evaluation, the global test of MR-PRESSO, and a leave-one-out methodological analysis. Ultimately, a reverse Mendelian Randomization analysis was conducted to assess the potential for reciprocal causality.ResultsThe outcomes derived from IVW substantiated that the presence of Family Streptococcaceae (OR = 0.44, P = 0.034), Family Veillonellaceae (OR = 0.46, P = 0.018), and Genus Dorea (OR = 0.29, P = 0.041) exerted a protective influence against BTC. Conversely, Class Lentisphaeria (OR = 2.21, P = 0.017), Genus Lachnospiraceae FCS020 Group (OR = 2.30, P = 0.013), and Order Victivallales (OR = 2.21, P = 0.017) were associated with an adverse impact. To assess any reverse causal effect, we used BTC as the exposure and the gut microbiota as the outcome, and this analysis revealed associations between BTC and five different types of gut microbiota. The sensitivity analysis disclosed an absence of empirical indicators for either heterogeneity or pleiotropy.ConclusionThis investigation represents the inaugural identification of indicative data supporting either beneficial or detrimental causal relationships between gut microbiota and the risk of BTC, as determined through the utilization of MR methodologies. These outcomes could hold significance for the formulation of individualized therapeutic strategies aimed at BTC prevention and survival enhancement.

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Gut microbe–host interactions in post-COVID syndrome: a debilitating or restorative partnership?

Scheithauer,

Montijn,

Mieremet

2024

Gut Microbes

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Post-COVID syndrome (PCS) patients have reported a wide range of symptoms, including fatigue, shortness of breath, and diarrhea. Particularly, the presence of gastrointestinal symptoms has led to the hypothesis that the gut microbiome is involved in the development and severity of PCS. The objective of this review is to provide an overview of the role of the gut microbiome in PCS by describing the microbial composition and microbial metabolites in COVID-19 and PCS. Moreover, host–microbe interactions via the microbiota-gut-brain (MGB) and the microbiota-gut-lung (MGL) axes are described. Furthermore, we explore the potential of therapeutically targeting the gut microbiome to support the recovery of PCS by reviewing preclinical model systems and clinical studies. Overall, current studies provide evidence that the gut microbiota is affected in PCS; however, diversity in symptoms and highly individual microbiota compositions suggest the need for personalized medicine. Gut-targeted therapies, including treatments with pre- and probiotics, have the potential to improve the quality of life of affected individuals.

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Causal Effects between Gut Microbiome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Two-Sample Mendelian Randomization Study

Cited by 3 publications

References 51 publications

The gastrointestinal microbiota in the development of ME/CFS: a critical view and potential perspectives

The gastrointestinal microbiota in the development of ME/CFS: a critical view and potential perspectives

The causal relationship between gut microbiota and biliary tract cancer: comprehensive bidirectional Mendelian randomization analysis

Gut microbe–host interactions in post-COVID syndrome: a debilitating or restorative partnership?

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