Causal associations and shared genetic etiology of neurodegenerative diseases with epigenetic aging and human longevity
Yu Guo,
Guojuan Ma,
Yukai Wang
et al.
Abstract:The causative mechanisms underlying the genetic relationships of neurodegenerative diseases with epigenetic aging and human longevity remain obscure. We aimed to detect causal associations and shared genetic etiology of neurodegenerative diseases with epigenetic aging and human longevity. We obtained large‐scale genome‐wide association study summary statistics data for four measures of epigenetic age (GrimAge, PhenoAge, IEAA, and HannumAge) (N = 34,710), multivariate longevity (healthspan, lifespan, and except… Show more
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