Causal association of sleep disturbances and low back pain: A bidirectional two-sample Mendelian randomization study

Luo, Guangsheng; Yao, Yuanyuan; Tao, Jiachun; Wang, Tingting; Yan, Min

doi:10.3389/fnins.2022.1074605

Cited by 15 publications

(11 citation statements)

References 51 publications

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“…These 3 methods differ in their assumptions about the effectiveness of IVs. The IVW method assumes that all included SNPs meet the IVs assumptions; the weighted median method assumes that only 50% of the included SNPs meet the IV assumption 24 ; and MR‐Egger assumes that IVs will affect the outcome through confounding factors in addition to their effect on the exposure, which will result in weaker statistical power 20 . As IVW is currently the most widely accepted method used to determine causation relationships between exposure and outcome, 25,26 we also used IVW as our primary analytical method.…”

Section: Methodsmentioning

confidence: 99%

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Psychological Distress and Meniere's Disease: A Bidirectional Two‐Sample Mendelian Randomization Study

Wu,

Xia,

Luo

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveThis study is aim to explore the causal relationship between anxiety, depression, neuroticism, and Meniere's disease (MD).Study DesignTwo‐sample bidirectional Mendelian randomization (MR) analyses.SettingIEU, FinnGen, CTG, and UKB databases.MethodsThe genome‐wide association studies data for anxiety, depression, neuroticism, and MD involved over 357,957 participants. MR was performed to explore relationships between anxiety, depression, neuroticism, and MD. Sensitivity analyses were performed to assess the robustness of the MR results. Reverse MR was used to exclude the possibility of reverse causality. Finally, multivariate MR was performed to explore the collinear relationships between neuroticism subclusters.ResultsMR results showed that anxiety and depression are not causes of MD, nor does MD cause anxiety and depression. Elevated neuroticism sum score is a cause of anxiety, depression, and MD, but MD does not lead to an increase in the level of neuroticism sum score. Further analysis showed that the 5 subclusters of neuroticism often feel lonely, mood often goes up and down, often feel fed‐up, feelings easily hurt, and sensitivity to environmental stress and adversity are causes of MD. Multivariate MR analysis results suggested that the 5 neuroticism subclusters have a collinear relationship.ConclusionAnxiety and depression are not causative factors of MD, and vice versa. Elevated neuroticism levels serve as a shared causative factor for anxiety, depression, and MD. Identification and effective management of neuroticism is a potential target for preventing and treating MD.

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Section: Methodsmentioning

confidence: 99%

“…All statistical analyses in this study were conducted using R ver. R.4.2.3 with the “TwoSampleMR”, “MVMR”, and “MendelianRandomization” packages 24,35 . Unless specified otherwise, a 2‐tailed P < 0.05 was considered significant for the results 36 …”

Section: Methodsmentioning

confidence: 99%

Psychological Distress and Meniere's Disease: A Bidirectional Two‐Sample Mendelian Randomization Study

Wu,

Xia,

Luo

et al. 2023

Otolaryngol.--head neck surg.

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“…The weighted median gives an accurate estimate based on the assumption that the number of valid IVs is 50%. At this point, the causal impact can still be computed accurately (28,29). The MR-Egger regression technique implies that all IVs are invalid, and its estimation accuracy is relatively low (30,31).…”

Section: Mendelian Randomization Analysismentioning

confidence: 99%

“…The MR-Egger intercept method calculates the intercept term available after the linear regression analysis to determine the likelihood of horizontal pleiotropy (34). The MR-PRESSO examination assesses the total pleiotropy of the study and examines for abnormal SNPs that may have horizontal pleiotropy (28). We utilized the software program to increase the number of distributions in the MR-PRESSO analysis to 5,000 and then performed a global test to notice whether there was pleiotropy in the study.…”

Section: Heterogeneity and Horizontal Pleiotropymentioning

confidence: 99%

The relationship between major depression and migraine: A bidirectional two-sample Mendelian randomization study

Tang

et al. 2023

Front. Neurol.

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BackgroundPrevious epidemiological and other studies have shown an association between major depressive disorder (MDD) and migraine. However, the causal relationship between them remains unclear. Therefore, this study aimed to investigate the causal relationship between MDD and migraine using a bidirectional, two-sample Mendelian randomization (MR) approach.MethodsData on MDD and migraine, including subtypes with aura migraine (MA) and without aura migraine (MO), were gathered from a publicly available genome-wide association study (GWAS). Single nucleotide polymorphisms (SNPs) utilized as instrumental variables (IVs) were then screened by adjusting the intensity of the connection and removing linkage disequilibrium. To explore causal effects, inverse variance weighting (IVW) was used as the primary analysis method, with weighted median, MR-Egger, simple mode, and weighted mode used as supplementary analytic methods. Furthermore, heterogeneity and pleiotropy tests were carried out. Cochran’s Q-test with IVW and MR-Egger was used to assess heterogeneity. Pleiotropy testing was carried out using the MR-Egger intercept and MR-PRESSO analysis methods. A leave-one-out analysis was also used to evaluate the stability of the findings. Finally, we used migraine (MA and MO) levels to deduce reverse causality with MDD risk.ResultsRandom effects IVW results were (MDD-Migraine: odds ratio (OR), 1.606, 95% confidence interval (CI), 1.324–1.949, p = 1.52E-06; MDD-MA: OR, 1.400, 95%CI, 1.067–1.8378, p = 0.015; MDD-MO: OR, 1.814, 95%CI, 1.277–2.578, p = 0.0008), indicating a causal relationship between MDD levels and increased risk of migraine (including MA and MO). In the inverse MR analysis, the findings were all negative, while in sensitivity analyses, the results were robust except for the study of MA with MDD.ConclusionOur study confirms a causal relationship between MDD levels and increased risk of migraine, MA, and MO. There was little evidence in the reverse MR analysis to suggest a causal genetic relationship between migraine (MA and MO) and MDD risk levels.

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“…Multiple research studies consistently indicate that depression, osteoporosis, and sleep disorders are closely associated with LBP. The presence of sleep disorders such as osteoporosis and depression has been shown to be associated with a higher prevalence of LBP [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Association between Body Composition and Chronic Low Back Pain in Korean Adults Aged over 50 Years: The Korea National Health and Nutrition Examination Survey (KNHANES) 2010–2011

Shim¹,

Ryu²,

Cho³

et al. 2023

Med Princ Pract

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Background The relationship between overweight or obesity and low back pain (LBP) has previously been investigated. Several recent studies have focused on the relationship between other indicators of obesity, particularly indicators of fat and the risk of LBP. However, the results of body composition and LBP have been inconsistent. Methods All data for the present retrospective, cross-sectional study was extracted from the Korea National Health and Nutrition Examination Survey (KNHANES) versions V-1 and 2 conducted in 2010 and 2011 by the Korean Centers for Disease Control and Prevention. In KNHANES V-1 (2010) and V-2 (2011), those over 50 years of age completed the surveys on LBP, body weight, and body composition assessed using dual-energy X-ray absorptiometry (DXA) were included. The multivariable logistic regression analysis was used to examine the relationship between the presence of chronic LBP and body composition adjusting for confounders. Results We analyzed 3,579 persons who completed the question. In the multivariable analyses adjusting for age and sex, none of the variables, including fat mass and fat-free mass, remained positively or negatively associated with LBP. Additionally, when depression, smoking, alcohol intake, physical activity, diabetes mellitus, and fat or lean tissue mass were included in the multivariable logistic model, no significant associations were found between all measures of fat mass, fat-free mass, and LBP Conclusion This study is contrary to previous studies that concluded that there is a correlation between obesity and fat mass and LBP. LBP is not associated with increased levels of obesity and fat mass.

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Causal association of sleep disturbances and low back pain: A bidirectional two-sample Mendelian randomization study

Cited by 15 publications

References 51 publications

Psychological Distress and Meniere's Disease: A Bidirectional Two‐Sample Mendelian Randomization Study

Psychological Distress and Meniere's Disease: A Bidirectional Two‐Sample Mendelian Randomization Study

The relationship between major depression and migraine: A bidirectional two-sample Mendelian randomization study

Association between Body Composition and Chronic Low Back Pain in Korean Adults Aged over 50 Years: The Korea National Health and Nutrition Examination Survey (KNHANES) 2010–2011

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