Informal caregiving, meaning taking health-related care of an older and/or disabled person in the personal network, often has consequences for paid work. Classically scholars focus on two strategies of informal caregivers to adapt employment: stopping and reducing working hours. Two other, but neglected, plausible strategies may similarly have career consequences, namely changing jobs and becoming self-employed. We first assess the theoretical idea that a work-care conflict is a condition for choosing a work adaption strategy. Second, we theoretically and empirically explore a life course (i.e., timing) and gender perspective on strategies to adapt paid work. We use detailed Dutch retrospective data on informal caregiving, collected within LISS panel (N=3,676 caregiving episodes of 2,114 caregivers). Based on multilevel logistic regression models, we find that caregivers who felt that they had difficulties combining work and care, were more likely to choose any strategy. Especially caregivers who started to provide care at the age of 24 or younger were more likely to reduce working hours or change jobs. In the early family formation stage (25-34 years), women were more likely to reduce working hours, while in early middle age (45-54 years) men were more likely to stop working.