Caudate Nucleus Volumes in Frontotemporal Lobar Degeneration: Differential Atrophy in Subtypes

Looi, Jeffrey Cl; Lindberg, Olof; Zandbelt, Bram B.; Östberg, Per; Kronborg, Christian; Botes, Lisa; Svensson, Leif; Wahlund, Lars‐Olof

doi:10.3174/ajnr.a1168

Cited by 54 publications

(69 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other reports also highlight atrophy of extra-temporal regions, such VMPFC, anterior cingulate and insular cortices, particularly in the more advanced stages [2,17]. Subcortical grey matter atrophy is mainly circumscribed to the caudate nucleus [18]. In keeping with the grey matter findings, white matter tracts within the temporal lobes are consistently affected with significant changes identified in the inferior longitudinal fasciculus (ILF) and uncinate fasciculus (UNC) [19].…”

Section: Introductionsupporting

confidence: 59%

“…Nevertheless, NFV-PPA can also present with more dorsal prefrontal as well as anterior parietal lobe changes, and striatal caudate atrophy [2,18]. The superior longitudinal fasciculus (SLF) tract undergoes the most severe changes in specifically the anterior part descending into the inferior frontal lobes and the posterior part descending into the posterior temporal lobe [11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Grey and white matter brain network changes in frontotemporal dementia subtypes

Nguyen

Bertoux

O’Callaghan

et al. 2013

Translational Neuroscience

View full text Add to dashboard Cite

Grey and whIte matter braIn network chanGes In frontotemporal dementIa subtypes abstract Background: Frontotemporal dementia (FTD) comprises of three clinical syndromes, behavioural-variant frontotemporal dementia (bvFTD), semantic dementia (SV-PPA), and progressive nonfluent aphasia (NFV-PPA) with unique underlying neuroanatomical deficits. To date, however, grey matter structural differences and their connecting white matter tracts in this network have been mostly characterised in comparison to controls, whereas within FTD subtype comparisons in the same patients have not been explored. Methodology: In 94 participants, including bvFTD (n = 16), SV-PPA (n = 16) and NFV-PPA (n = 16), as well as an age-matched control group (n = 46), we employed voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) to examine grey and white matter key signatures in each of the three FTD subtypes. Results: Our results showed that bvFTD had specific ventromedial prefrontal cortex and striatum grey matter atrophy along with their connecting white matter tracts compared to other FTD subtypes. By contrast, SV-PPA showed additional temporal pole grey matter damage to bvFTD and grey and white matter temporal, amygdala and insula changes compared to NFV-PPA. Finally, NFV-PPA showed mild insula grey and white matter changes compared to bvFTD but differed from SV-PPA only on anterior corpus callosum white matter changes. Conclusions: Our findings clearly indicate that not only grey matter regions of the FTD network but also their white matter connecting tracts have specific signatures for each FTD subtype. These promising findings highlight how neural network approaches can shed new light on neurodegenerative conditions and FTD in particular, which will inform future diagnostic and disease management. keywords

show abstract

Section: Introductionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Grey and white matter brain network changes in frontotemporal dementia subtypes

Nguyen

Bertoux

O’Callaghan

et al. 2013

Translational Neuroscience

View full text Add to dashboard Cite

show abstract

“…1,2 The neuropathophysiology of FTLD involves frontostriatal neural circuits, which comprise the following: the origin from a prefrontal region, via the caudate, putamen, or nucleus accumbens, via the globus pallidus, via the thalamus, and thence, with feedback to the prefrontal cortex. 1,3 Frontostriatal circuits serve several domains of cognitive function affected in FTLD. 4,5 Differential cognitive dysfunction mediated via frontostriatal circuits in FTLD may be reflected in structural changes in components of that circuitry.…”

mentioning

confidence: 99%

Putaminal Volume in Frontotemporal Lobar Degeneration and Alzheimer Disease: Differential Volumes in Dementia Subtypes and Controls

Looi¹,

Svensson²,

Lindberg³

et al. 2009

AJNR Am J Neuroradiol

Self Cite

View full text Add to dashboard Cite

show abstract

“…40 Frontostriatal dysfunction also varies among these different subtypes, with the behavioral variant having the greatest involvement: Caudate heads are relatively reduced in size in these patients compared with those with the language variant of frontotemporal lobar degeneration. 59 Creutzfeldt-Jakob Disease. In Creutzfeldt-Jakob disease, a rare, rapidly progressive neurodegenerative condition caused by prion infection, VHs may accompany the typical rapid cognitive decline, anxiety, personality change, myoclonic jerks, and ataxia.…”

Section: 45mentioning

confidence: 99%

Distinguishing Neuroimaging Features in Patients Presenting with Visual Hallucinations

Winton-Brown¹,

Ting

Mocellin³

et al. 2016

American Journal of Neuroradiology

View full text Add to dashboard Cite

SUMMARY:Visual hallucinations are relatively uncommon presentations in medical and psychiatric clinics, where they are generally regarded as a marker of possible underlying "organic" brain disease. Thus, patients with visual hallucinations are often referred for imaging of the brain. This article presents a pragmatic approach for the radiologist reviewing such imaging. Because conditions that can present with visual hallucinations are legion, a familiarity with the features of the hallucinations themselves, which can serve as clues to the underlying cause, can be helpful in interpreting such cases. We consider the nature of visual hallucinations and the mechanisms underlying their formation. We then provide a framework to guide the search for their cause, first in terms of focal lesions along the visual pathway and then global conditions affecting Ͼ1 region. ABBREVIATIONS:CJD ϭ Creutzfeldt-Jakob disease; VH ϭ visual hallucination

show abstract

Caudate Nucleus Volumes in Frontotemporal Lobar Degeneration: Differential Atrophy in Subtypes

Cited by 54 publications

References 27 publications

Grey and white matter brain network changes in frontotemporal dementia subtypes

Grey and white matter brain network changes in frontotemporal dementia subtypes

Putaminal Volume in Frontotemporal Lobar Degeneration and Alzheimer Disease: Differential Volumes in Dementia Subtypes and Controls

Distinguishing Neuroimaging Features in Patients Presenting with Visual Hallucinations

Contact Info

Product

Resources

About