Caudate nucleus lesion selectively increases paradoxical sleep episodes in the rat

Corsi-Cabrera, María; Grinberg-Zylberbaum, J.; Arditti, L.S.

doi:10.1016/0031-9384(75)90133-x

Cited by 15 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, the availability of striatal dopamine in D2/D3 receptors has been associated with sleep quality in healthy adults [76]. Consistent with this view, and with our findings in healthy volunteers, lesion studies in the rodent model have documented alteration of sleep-wake behavior following striatal damage [58,77]. In particular, striatal lesions have been shown to lead to an increased number of state transitions and loss of ultra-long wake bouts (i.e., greater sleep fragmentation) [78].…”

Section: Discussionsupporting

confidence: 89%

The subcortical basis of subjective sleep quality

Monti

2024

Preprint

View full text Add to dashboard Cite

Study objectivesTo assess the association between self-reported sleep quality and cortical and subcortical local morphometry.MethodsSleep and neuroanatomical data from the full release of the young adult Human Connectome Project dataset were analyzed. Sleep quality was operationalized with the Pittsburgh Sleep Quality Index (PSQI). Local cortical and subcortical morphometry was measured with subject-specific segmentations resulting in voxelwise thickness measurements for cortex and relative (i.e., cross-sectional) local atrophy measurements for subcortical regions.ResultsRelative atrophy across several subcortical regions, including bilateral pallidum, striatum, and thalamus, was negatively associated with both global PSQI score and sub-components of the index related to sleep duration, efficiency, and quality. Conversely, we found no association between cortical morphometric measurements and self-reported sleep quality.ConclusionsThis work shows that subcortical regions such as the bilateral pallidum, thalamus, and striatum, might be interventional targets to ameliorate self-reported sleep quality.Statement of SignificanceIn this study we address, with a novel sensitive approach, the relationship between subjective sleep quality and neuroanatomy in a large population of young adults. We find that measures of subjective sleep quality are inversely related to atrophy in deep brain nuclei including the bilateral pallidum, striatum, and thalamus. These results provide potential intervention targets for mitigating sleep-related disorders and improving sleep quality.

show abstract

Section: Discussionsupporting

confidence: 89%

The subcortical basis of subjective sleep quality

Monti

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…1. This includes the striatum as, although it is not considered to be a key part of the sleep-wake process (see above), studies involving striatal lesions have nevertheless suggested a possible involvement with sleep [23,100,173]. This effect may be mediated through the outflow of the basal ganglia to critical thalamic nuclei and the PPT [56,77].…”

Section: Neural Pathway Disruptionmentioning

confidence: 92%

How vital is sleep in Huntington’s disease?

Goodman

Barker

2010

J Neurol

View full text Add to dashboard Cite

Huntington's disease (HD) is a fatal neurodegenerative disease caused by an abnormal expansion of a CAG repeat in exon 1 of the HD gene on chromosome 4. The disease runs a debilitating and progressive course with an average survival of 15-25 years after disease onset. HD patients classically develop involuntary movements including chorea, as well as progressive cognitive and psychiatric disturbances, although a number of other features have also been reported, including changes in sleep and circadian rhythms; it is this latter area that forms the focus of this review.

show abstract

“…The effects of caudate lesions on S–W had been examined previously only in rats (e.g. Corsi‐Cabrera et al. , 1975), but their lesions were partial and, more importantly, abundant cortical–subcortical fibers cross the caudate n. in rats and these axons were destroyed by the lesion method employed in those studies.…”

Section: 2 the Caudate Nucleusmentioning

confidence: 99%

Counterpointing the functional role of the forebrain and of the brainstem in the control of the sleep–waking system

Villablanca

2004

Journal of Sleep Research

View full text Add to dashboard Cite

SUMMAR Y This paper reviews the lifetime contributions of the author to the field of sleepwakefulness (S-W), reinterprets results of the early studies, and suggests new conclusions and perspectives. Long-term cats with mesencephalic transection show behavioral/polygraphic rapid eye movement sleep (REMS), including the typical oculopupillary behavior, even when the section is performed in kittens prior to S-W maturation. REMS can be induced as a reflex. Typical non-rapid eye movement S (NREMS) is absent and full W/arousal is present only after a precollicular section. The isolated forebrain (IF) rostral to the transection exhibits all features of W/arousal and NREMS [with electroencephalographic (EEG) spindles and delta waves], arousal to olfactory stimuli, and including the appropriate oculo-pupillary behaviors. These features also mature normally after neonatal transection. REMS is absent from the IF. After deprivation there is NREMS pressure and rebound in the IF, but the decerebrate cat only shows pressure for REMS. Most IF reactions to pharmacologic agents are within expectations, except for the tolerance/withdrawal effects of long-term morphine use which are absent. In contrast, these effects are supported by the brainstem (i.e. seen in the decerebrate cat). In cats with ablation of the telencephalon, or diencephalic cats, delta waves are absent in the thalamus. EEG thalamic spindle waves are seen triggering S for only 4-5 days after ablation. Therefore, true NREMS is absent in chronic diencephalic cats although pre-and postsomniac behaviors persist. These animals are hyperactive and show a pronounced, permanent insomnia; however, a low dose of barbiturate triggers a dramatic REMS/atypical NREMS rebound. Cats without the thalamus (athalamic cats), initially show a dissociation between behavioral hyperactivity/insomnia and the neocortical EEG, which for 15-20 days exhibits only delta and slower oscillations. Fast, low-voltage W rhythms appear later on, first during REMS, but spindle waves and S postures are absent from the start, such that these cats also display only atypical NREMS. Athalamic cats also show barbiturate-sensitive insomnia. Cats with ablation of the frontal cortices or the caudate nuclei remain permanently hyperactive. They also show a mild, but significant hyposomnia, which is permanent in afrontal cats, but lasts for about a month in acaudates. The polygraphic/ behavioral features of their S-W states remain normal. We conclude and propose that: (a) the control of the S-W system is highly complex and distributed, but is organized hierarchically in a well-defined rostro-caudal manner; the rostral-most or highest level (telencephalon), is the most functionally complex/adaptative and regulates the lower levels; the diencephalic/basal forebrain, or middle level, has a pivotal role in inducing switching between S and W and in coordinating the lowest (brainstem) and highest levels; (b) W can occur independently in both the forebrain and brainstem, but true NREMS-and REMS-generating mechanisms exis...

show abstract

Caudate nucleus lesion selectively increases paradoxical sleep episodes in the rat

Cited by 15 publications

References 7 publications

The subcortical basis of subjective sleep quality

The subcortical basis of subjective sleep quality

How vital is sleep in Huntington’s disease?

Counterpointing the functional role of the forebrain and of the brainstem in the control of the sleep–waking system

Contact Info

Product

Resources

About