Caudate nucleus and memory for egocentric localization

Cook, David J.; Kesner, Raymond P.

doi:10.1016/s0163-1047(88)90338-x

Cited by 241 publications

(134 citation statements)

References 13 publications

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“…For example, it has been shown that electrolytic induced caudate lesions in rats impair short-term or working memory for a specific motor response (right-left turn) without any impairments in memory for a visual object or for a spatial location . Similarly, a lack of effects has been reported following medial caudate lesions in working memory performance for spatial locations on an 8 arm maze (Colombo, Davis, & Volpe, 1989;Cook & Kesner, 1988). A similar pattern of results has been reported following dysfunction of the caudate nucleus in patients with HD.…”

Section: Short-term or Working Memory --Response Attributesupporting

confidence: 60%

“…With respect to response attribute information, it can be shown that with the use of the above mentioned paradigms to measure short-term memory, that for rats with caudateputamen lesions and humans with caudate-putamen damage due to Huntington's disease (HD), there are profound deficits for a right or left turn response or a list of hand motor movement responses (Cook & Kesner, 1988;Davis, Filoteo, Kesner, & Roberts, 2003;Kesner et al, 1993; Figure 3 depicts the location of the caudate nucleus in the rat). For example, it has been shown that electrolytic induced caudate lesions in rats impair short-term or working memory for a specific motor response (right-left turn) without any impairments in memory for a visual object or for a spatial location .…”

Section: Short-term or Working Memory --Response Attributementioning

confidence: 99%

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Neurobiological foundations of an attribute model of memory

Kesner¹

2013

CCBR

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Memory is a complex phenomenon due to a large number of potential interactions that are associated with the organization of memory at the psychological and neural system level. In this review article a tripartite, multiple attribute, multiple process memory model with different forms of memory and its neurobiological underpinnings is represented in terms of the nature, structure or content of information representation as a set of different attributes including language, time, place, response, reward value (affect) and visual object as an example of sensory-perception. For each attribute, information is processed in the event-based, knowledge-based, and rule-based memory systems through multiple operations that involve multiple neural underpinnings. Of the many processes associated with the event-based memory system, the emphasis will be placed on short-term or working memory and pattern separation. Of the many processes associated with the knowledgebased memory system, the emphasis will be placed on perceptual processes. Of the many processes associated with the rule-based memory system the emphasis will be on short-term or working memory and paired associate learning. For all three systems data will be presented to demonstrate differential neuroanatomical mediation and where available parallel results will be presented in rodents, monkeys and humans.

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Section: Short-term or Working Memory --Response Attributesupporting

confidence: 60%

Section: Short-term or Working Memory --Response Attributementioning

confidence: 99%

Neurobiological foundations of an attribute model of memory

Kesner¹

2013

CCBR

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“…The alteration of attention and/or sensory processing, may strengthen response, place, or cue strategies, depending on the surrounding environment. Such an explanation could account for the contradictory results in the literature concerning the role of dorsal striatum in egocentric discriminations (Potegal, 1969;Cook and Kesner, 1988;Kesner et al, 1993;DeCoteau and Kesner, 2000versus Divac et al, 1967, 1978Kirkby, 1969;Pisa and Cyr, 1990;Oliveira et al, 1997).…”

Section: Resultsmentioning

confidence: 96%

“…Several studies have shown impairment in the acquisition of tasks that require the use of an egocentric strategy after lesions of the dorsal striatum (Potegal, 1969;Cook and Kesner, 1988;Kesner et al, 1993;DeCoteau and Kesner, 2000). This position has, however, been challenged by other studies postulating that dorsal striatum is not involved in egocentric discriminations (Divac et al, 1967(Divac et al, , 1978Kirkby, 1969;Pisa and Cyr, 1990;Oliveira et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Re-thinking the role of the dorsal striatum in egocentric/response strategy

Botreau

2010

Front. Behav. Neurosci.

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“…In a later study by the same group, latency was unaffected, although they reported that on the last day of testing there was a significant reduction in a measure of 'directness' in the MA-treated group (Chapman et al, 2001;Daberkow et al, 2005). While it is appreciated that the motor learning task above and the CWM involve learning a sequence to solve the task, and the neostriatum has been implicated in sequence learning (Potegal, 1972;Cook and Kesner, 1988), the ability of animals to learn in the CWM may be different. Most notably, the CWM was run under infrared lighting, eliminating distal and local surrounding cues, whereas the motor learning task was run under lighted conditions.…”

Section: Discussionmentioning

confidence: 99%

Effect of (+)-methamphetamine on path integration learning, novel object recognition, and neurotoxicity in rats

et al. 2008

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Rationale-Methamphetamine (MA) has been implicated in cognitive deficits in humans after chronic use. Animal models of neurotoxic MA exposure reveal persistent damage to monoaminergic systems, but few associated cognitive effects.Objectives-Since, questions have been raised about the typical neurotoxic dosing regimen used in animals and whether it adequately models human cumulative drug exposure, these experiments examined two different dosing regimens.Methods-Rats were treated with one of two regimens, one the typical neurotoxic regimen (4 × 10 mg/kg every 2 h) and one based on pharmacokinetic modeling (Cho et al. 2001) designed to better represent accumulating plasma concentrations of MA as seen in human users (24 ×1.67 mg/kg once every 15 min); matched for total daily dose. In two separate experiments, dosing regimens were compared for their effects on markers of neurotoxicity or on behavior.Results-On markers of neurotoxicity, MA showed decreased DA and 5-HT, and increased glial fibrillary acidic protein and increased corticosterone levels regardless of dosing regimen 3 days posttreatment. Behaviorally, MA-treated groups, regardless of dosing regimen, showed hypoactivity, increased initial hyperactivity to a subsequent MA challenge, impaired novel object recognition, impaired learning in a multiple-T water maze test of path integration, and no differences on spatial navigation or reference memory in the Morris water maze. After behavioral testing, reductions of DA and 5-HT remained.Conclusions-MA treatment induces an effect on path integration learning not previously reported. Dosing regimen had no differential effects on behavior or neurotoxicity.

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Caudate nucleus and memory for egocentric localization

Cited by 241 publications

References 13 publications

Neurobiological foundations of an attribute model of memory

Neurobiological foundations of an attribute model of memory

Re-thinking the role of the dorsal striatum in egocentric/response strategy

Effect of (+)-methamphetamine on path integration learning, novel object recognition, and neurotoxicity in rats

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