Caudal Regression Syndrome

Vissarionov, Sergey; Kazaryan, Irina

doi:10.14531/ss2010.2.50-55

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…In the context of embryogenesis, this defect is a result of a failure of notochord formation occurring at the stage of gastrulation. 2,3…”

Section: Introductionmentioning

confidence: 99%

“…In the context of embryogenesis, this defect is a result of a failure of notochord formation occurring at the stage of gastrulation. 2,3 Renshaw et al 4 divide the condition into 4 groups ( Figure 1): type I is defined as a partial or total unilateral sacral agenesis. Type II has a partial sacral agenesis with a bilateral symmetrical defect, a normal or hypoplastic sacral vertebra, and an articulation between the ilia and the first sacral vertebra.…”

Section: Introductionmentioning

confidence: 99%

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Surgical Correction of Spinopelvic Instability in Children With Caudal Regression Syndrome

Vissarionov

Schroder

Kokushin

et al. 2018

Global Spine Journal

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Study Design: Retrospective cohort. Objective: To analyze the outcome of surgical correction of children with caudal regression syndrome. Methods: The study included 12 patients aged 1.5 to 9 years with caudal regression syndrome. In order determine the type of caudal regression, the Renshaw Classification was used. The surgery included correction and stabilization of the kyphotic deformity at the unstable lumbosacral region, with reconstruction of the sagittal balance using a bony block constructed from allograft. Short- and long-term outcomes were evaluated. The study was approved by the local institutional review board. Results: Children with types III and IV caudal regression syndrome underwent spinal-pelvic fusion, with 100% fusion rate, which allows sufficient stabilization of the lumbopelvic segment permitting patient mobilization and standing in type III patients. There were 5 complications needing additional care. Conclusion: Multilevel pedicular screw fixation in combination with spinopelvic fusion with cortical allografts allows reconstruction of the sagittal alignment with solid bony fusion improving the quality of life for these patients.

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“…In the context of embryogenesis, this defect is a result of a failure of notochord formation occurring at the stage of gastrulation. 2,3…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surgical Correction of Spinopelvic Instability in Children With Caudal Regression Syndrome

Vissarionov

Schroder

Kokushin

et al. 2018

Global Spine Journal

View full text Add to dashboard Cite

show abstract

Treatment of patients with caudal regression syndrome: a systematic review of the literature

et al. 2023

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Objective. To analyze and summarize the data of modern literature on the issues of surgical treatment and natural course of the spine and spinal cord pathology in patients with various types of caudal regression syndrome (CRS).Material and Methods. A systematic review of the literature on the issue of treatment of the spine and spinal cord pathology in patients with CRS was performed. Selection criteria were: articles for the period 2002–2022, original studies of populations/patients with various forms of CRS with a description of treatment methods and long-term results of treatment or observation. A total of 28 articles on the treatment of various forms of CRS with the described results of treatment of 212 patients were analyzed: 29 patients with CRS in combination with open neural tube defects and 183 patients with closed forms of CRS. Evaluation criteria included number of patients, gender, type of spinal cord pathology, type of sacral agenesis, presence of the spine and lower extremities deformities, concomitant pathology, operations performed and their complications, and results.Results. The studied patients underwent the following surgeries on the spine and spinal cord: untethering of the spinal cord, correction and stabilization surgeries on the spine, plasty of the spinal cord herniation, plasty of the terminal meningocele, and removal of the presacarial volumetric mass. The greatest number of complications occurred after operations on the spine and sacrum. The majority of patients (67 %) with sacral agenesis by the end of the follow-up period (average 14 years) walked independently or with the help of devices, and a minority of them (33 %) could not walk. More than half of patients with CRS (67 %) had a neurogenic bladder, urinary incontinence, or suffered from a chronic urinary tract infection. Fecal incontinence and constipation were less common (46 %).Conclusions. Patients with CRS have a good potential for improvement/recovery of walking and pelvic organ dysfunction. This is extremely important to timely carry out multimodality treatment of patients with CRS who have neurosurgical, orthopedic, urogenital and colorectal problems in CRS, and to start early motor rehabilitation and physiotherapy.

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Caudal Regression Syndrome

Abstract: The paper presents literature review on a rare congenital malformation of the spine and spinal cord. Key issues of etiology, classification, clinical presentation of caudal regression syndrome, and variants of conservative and surgical treatment are discussed.

Cited by 2 publications

References 30 publications

Surgical Correction of Spinopelvic Instability in Children With Caudal Regression Syndrome

Surgical Correction of Spinopelvic Instability in Children With Caudal Regression Syndrome

Treatment of patients with caudal regression syndrome: a systematic review of the literature

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