Caudal Epidural Butorphanol Plus Bupivacaine Versus Bupivacaine in Pediatric Outpatient Genitourniary Procedures

Lawhorn, C. David; Brown, Raeford E.; Schmitz, Michael L.; Huggins, D. P.; Kymer, Patti J.; Shirey, Robert; Volpe, Paula

doi:10.1097/00000542-199409001-01341

Cited by 2 publications

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“…É possível que tal fato deva-se às divergências farmacogenéticas de cada animal. Lawhorn (1997), ao utilizar butorfanol associado à bupivacaína, verificou diminuição do período de latência e aumento da duração da analgesia, sem complicações para o feto em mulheres. Para a realização de cirurgia como a OSH, faz-se necessário que a duração do bloqueio peridural seja relativamente prolongada, o que justificaria a escolha, no presente estudo, de um anestésico local de longa duração, como a ropivacaína, apesar de Feldman et al (1996) No presente estudo, foram observados períodos de duração de bloqueio sensitivo e motor superiores aos encontrados pela maioria dos autores, o que pode ser justificado pelo maior volume utilizado, semelhante ao resultado de Otero (2005), ao afirmar que a qualidade do bloqueio sensitivo e motor, ou seja, o começo da ação, a profundidade e sua duração dependerão, principalmente, da quantidade total de fármaco administrado.…”

Section: Resultsunclassified

Influência do butorfanol sobre os períodos de latência e de ação da ropivacaína pela via peridural na ovariossalpingo-histerectomia em cadelas

Albuquerque¹,

Souza²,

Vivan³

et al. 2010

Arq. Bras. Med. Vet. Zootec.

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 RESUMOAvaliaram-se os períodos de latência e de duração do efeito do butorfanol associado à ropivacaína aplicados pela via peridural e a possibilidade de uso dessa associação como protocolo anestésico para realização de ovariossalpingo-histerectomia (OSH) em cadelas. Utilizaram-se 16 cadelas pré-medicadas com acepromazina e midazolam compondo dois grupos: no grupo 1 (n=8) aplicou-se ropivacaína isolada (0,3mL/kg) e no grupo 2 (n=8), butorfanol (0,1mg/kg) e ropivacaína (até o volume de 0,3mL/kg), pela via peridural. Consideraram-se nove momentos (M): M 0 -animal sem anestesia, M 1 -15 minutos após medicação pré-anestésica; M 2 -30 minutos após a aplicação peridural; M 3 , M 4 e M 5 -correspondentes ao início do procedimento e ao pinçamento dos pedículos esquerdo e direito, respectivamente; M 6 -ligadura da cérvix uterina; e M 7 e M 8 -início da laparorrafia e fim da sutura de pele, respectivamente. Foram avaliados os períodos de latência e ação do bloqueio, além da viabilidade de realização do procedimento cirúrgico por meio do bloqueio efetuado. O que recebeu ropivacaína + butorfanol apresentou sedação pronunciada e permitiu a realização de OSH em 75% dos animais, sem indução anestésica. Não houve diferença entre os grupos quanto aos períodos de latência e duração. A associação do butorfanol à ropivacaína proporcionou bloqueio anestésico compatível com a realização de OSH e período de latência curto, com duração de efeito suficiente para o procedimento cirúrgico.Palavras-chave: cadela, butorfanol, ropivacaína, peridural ABSTRACT The periods of latency and duration of butorphanol associated with ropivacaine used via epidural, and this combination as anesthetic protocol for carrying out ovariosalpingohysterectomy (OSH) in bitches were

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Section: Resultsunclassified

Influência do butorfanol sobre os períodos de latência e de ação da ropivacaína pela via peridural na ovariossalpingo-histerectomia em cadelas

Albuquerque¹,

Souza²,

Vivan³

et al. 2010

Arq. Bras. Med. Vet. Zootec.

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“…[9][10][11][12][13] The present study was designed to compare between low dose (0.5 mg) butorphanol as adjuvant to epidural bupivacaine (0.5%) and epidural bupivacaine (0.5%) alone for perioperative analgesia in elective gynaecological surgeries. The use of combination of bupivacaine and butorphanol in epidural route is not new and has already been reported in different studies 7,[14][15][16][17] with variable modification of block characteristics.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Epidural Bupivacaine and Epidural Bupivacaine With Lowdose Butorphanol for Perioperative Analgesia in Patients Undergoing Elective Gynaecological Surgeries

Chattopadhyay¹,

Sarkar²,

Mandal³

et al. 2017

jemds

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BACKGROUNDEpidural anaesthesia with bupivacaine is a popular method of anaesthesia for gynaecological surgery. Several studies have already reported that opioids as neuraxial additive markedly prolonged the postoperative analgesic effect of local anaesthetics without much increase of adverse events. Sixty adult females of ASA physical status I and II, aged between 20 -60 years, scheduled for elective gynaecological surgery were included in this randomised double-blind controlled study.Aim of this study was to compare the efficacy of low-dose butorphanol as additive to epidural bupivacaine and epidural bupivacaine alone for perioperative analgesia. MATERIALS AND METHODSThe patients were randomly allocated into two equal groups to receive either 15 -20 mL of 0.5% bupivacaine hydrochloride (Group I, n = 30) or 15 -20 mL of 0.5% bupivacaine hydrochloride plus low-dose (0.5 mL) butorphanol tartrate (Group II, n = 30) according to computerised randomised table. The dose of 0.5% bupivacaine hydrochloride was calculated according to the height of the patient (i.e. 150 -160 cm: 15 mL and 160 cm onwards: 20 mL). Under all aseptic precautions, epidural anaesthesia was given with 18G Tuohy needle in sitting posture at L2-3 or L3-4 interspace using loss of resistance technique to identify epidural space. After negative aspiration test, the study drug was slowly injected as per protocol. No other analgesic was given to the patients intraoperatively. Onsets of sensory and motor block were assessed. Duration of sensory and motor block, height of block and duration of analgesia also were assessed. Time to first rescue analgesic was taken as the duration of analgesia; VAS and VRS scores at that point were also noted. The total number of doses of rescue analgesics required in first 24 hours was also noted. Blood pressure, heart rate and respiratory rate were recorded at stipulated intervals. Adverse events, if any were also noted. The data was analysed using appropriate statistical test. RESULTSThe onset and duration of sensory and motor blocks were comparable between the two groups. Duration of analgesia was significantly longer in patients receiving butorphanol additive group. Vital parameters were well maintained during intraoperative and postoperative period in both the groups. A few minor adverse events such as nausea, vomiting, pruritus and shivering were found in both the groups, but no significant difference on analysis. CONCLUSIONA single low-dose (0.5 mg) butorphanol along with epidural bupivacaine (0.5%) administration prolongs the duration of effective analgesia compared with bupivacaine (0.5%) alone. This low-dose (0.5 mg) butorphanol as additive does not appear to influence the speed of onset of blocks. Haemodynamic parameters and adverse events are also not influenced.

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Caudal Epidural Butorphanol Plus Bupivacaine Versus Bupivacaine in Pediatric Outpatient Genitourniary Procedures

Cited by 2 publications

References 0 publications

Influência do butorfanol sobre os períodos de latência e de ação da ropivacaína pela via peridural na ovariossalpingo-histerectomia em cadelas

Influência do butorfanol sobre os períodos de latência e de ação da ropivacaína pela via peridural na ovariossalpingo-histerectomia em cadelas

A Comparative Study of Epidural Bupivacaine and Epidural Bupivacaine With Lowdose Butorphanol for Perioperative Analgesia in Patients Undergoing Elective Gynaecological Surgeries

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