Abstract:Background: Factor Xa inhibitors are widely used by the physicians to reduce the incidence of thrombosis in order to protect the cardiovascular function. Although complications of bleeding and spontaneous gastrointestinal sources have been reported before, there are very sporadic cases of spinal epidural haematoma causing neurological compromise. Case presentation: We report a case of spontaneous spinal epidural haematoma (SSEH) in an 85-year-old female patient treated with Rivaroxaban, a new agent to prevent … Show more
“…While there are previous case reports on spontaneous SIEH secondary to VKAs use (warfarin) [3,4], recently there are emerging reports of SIEH secondary to the NOAC rivaroxaban alone [5,6].…”
Non-traumatic Spontaneous Intradural-Extramedullary Hematoma (SIEH) is a rare condition. Rivaroxaban is a Novel Oral Anticoagulant (NOAC), and there are few reports of rivaroxaban-associated SIEH. We report a 72-year-old male who had been taking rivaroxaban for his atrial fibrillation. He presented with sudden-onset paraplegia with a T7 sensory level and absent anal contraction. Magnetic resonance images of the spine revealed a long-segment T4-T8 ventral intradural extramedullary hematoma and T9-T10 dorsal intradural extramedullary hematoma both causing cord compression, associated with spinal cord oedema spanning from T8-T10 levels. To address the acute spinal cord compression, T4 to T10 laminectomy and evacuation of SIEH was performed for urgent spinal cord decompression. Sixteen months post-operation, he was able to ambulate independently albeit with residual bilateral lower limb weakness and numbness. Keywords: SIEH; spinal hematoma; laminectomy; hematoma evacuation; rivaroxaban; NOAC.
“…While there are previous case reports on spontaneous SIEH secondary to VKAs use (warfarin) [3,4], recently there are emerging reports of SIEH secondary to the NOAC rivaroxaban alone [5,6].…”
Non-traumatic Spontaneous Intradural-Extramedullary Hematoma (SIEH) is a rare condition. Rivaroxaban is a Novel Oral Anticoagulant (NOAC), and there are few reports of rivaroxaban-associated SIEH. We report a 72-year-old male who had been taking rivaroxaban for his atrial fibrillation. He presented with sudden-onset paraplegia with a T7 sensory level and absent anal contraction. Magnetic resonance images of the spine revealed a long-segment T4-T8 ventral intradural extramedullary hematoma and T9-T10 dorsal intradural extramedullary hematoma both causing cord compression, associated with spinal cord oedema spanning from T8-T10 levels. To address the acute spinal cord compression, T4 to T10 laminectomy and evacuation of SIEH was performed for urgent spinal cord decompression. Sixteen months post-operation, he was able to ambulate independently albeit with residual bilateral lower limb weakness and numbness. Keywords: SIEH; spinal hematoma; laminectomy; hematoma evacuation; rivaroxaban; NOAC.
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