Consider the spatially inhomogeneous Landau equation with moderately soft potentials (i.e. with γ ∈ (−2, 0)) on the whole space R 3 . We prove that if the initial data fin are close to the vacuum solution fvac ≡ 0 in an appropriate norm, then the solution f remains regular globally in time. This is the first stability of vacuum result for a binary collisional model featuring a long-range interaction.Moreover, we prove that the solutions in the near-vacuum regime approach solutions to the linear transport equation as t → +∞. Furthermore, in general, solutions do not approach a traveling global Maxwellian as t → +∞.Our proof relies on robust decay estimates captured using weighted energy estimates and the maximum principle for weighted quantities. Importantly, we also make use of a null structure in the nonlinearity of the Landau equation which suppresses the most slowly-decaying interactions. * jluk@stanford.edu 1 Each of these terms depends also on (t, x). For brevity, we have suppressed these dependence in (1.2).