Cattle hypocuprosis in Argentina associated with periodically flooded soils

Ramirez, C. E.; Mattioli, Guillermo Alberto; Tittarelli, Claudia Marcela; Giuliodori, Mauricio J.; Yano, Hideo

doi:10.1016/s0301-6226(98)00120-1

Cited by 20 publications

(21 citation statements)

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“…Although trace minerals are low in animal bodies, small quantities are required in the daily diet and are necessary for normal growth, development and reproduction (Hedaoo et al 2008). Relative studies have proven that low reproductive efficiency of grazing livestock results from trace mineral deficiency (Ramirez et al 1998;Cerri et al 2009). Relative studies have proven that low reproductive efficiency of grazing livestock results from trace mineral deficiency (Ramirez et al 1998;Cerri et al 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, minute fluctuations of trace mineral levels significantly affect biological functions (Navarro-Alarcon & Cabrera-Vique 2008). Relative studies have proven that low reproductive efficiency of grazing livestock results from trace mineral deficiency (Ramirez et al 1998;Cerri et al 2009). Selenium (Se), an essential trace element, is necessary for reproduction, immunity, antioxidant systems, embryonic growth and other physiological functions (Ahsan et al 2014;Petrujkic et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Selenium supplementation during in vitro maturation enhances meiosis and developmental capacity of yak oocytes

Xiong

Lan

et al. 2017

Animal Science Journal

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The objectives of the present study were to investigate the effects of selenium (Se) supplementation during in vitro maturation (IVM) on the developmental capacity of yak (Bos grunniens) oocytes. Nuclear maturation, DNA integrity, glutathione peroxidase (GSH-Px) activity, subsequent embryonic development, and gene expression after in vitro fertilization (IVF) were evaluated. The Se concentrations in yak plasma and follicular fluid were 0.142 and 0.069 μg/mL, respectively. The DNA damage in cumulus cells decreased significantly with 2 and 4 μg/mL supplementation of sodium selenite to IVM medium (P < 0.05). Total GSH-Px activity in oocytes increased in all Se supplementation groups, and the 2 and 4 μg/mL groups were significantly higher than the control group (0 μg/mL). However, the cleavage rate was not significantly different after Se supplementation (P > 0.05). The IVF blastocyst formation rates of 0, 1 and 4 μg/mL sodium selenite groups were 47.7%, 51.2% and 58.9%, respectively. The 2 μg/mL sodium selenite group had the highest blastocyst formation rate (60.5%). Gene expression analysis revealed that the quantity of transcripts associated with selenoprotein and protein synthesis were high in the 2 and 4 μg/mL groups. In conclusion, both GSH-Px activity of oocytes and DNA integrity of cumulus cells significantly increased with supplemental Se during oocyte IVM. Considering that embryonic development is responsive to Se supplementation, we inferred that appropriate Se concentrations during IVM were beneficial for yak oocyte maturation and subsequent development.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selenium supplementation during in vitro maturation enhances meiosis and developmental capacity of yak oocytes

Xiong

Lan

et al. 2017

Animal Science Journal

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“…Traditionally, cattle were thought to be relatively tolerant to Cu accumulation and as Cu deficiency is considered one of the main nutritional disorders in grazing cattle (Ramirez et al, 1998) (Suttle, 2010); but also other minerals such as iron (Fe) and zinc (Zn) (Kendall et al, 2001). However, in recent years an increase in the number of episodes of Cu toxicity has been reported in cattle reared under intensive systems (Bidewell et al, 2000;VLA, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Traditionally, cattle were thought to be relatively tolerant to Cu accumulation and as Cu deficiency is considered one of the main nutritional disorders in grazing cattle (Ramirez et al, 1998), cattle diets are regularly supplemented with high Cu concentrations. This supplementation can be up to 35 mg Cu/kg dry matter (DM), the maximum level of Cu supplementation for cattle established by the European Union (Commission Regulation 1334/2003/EC), well above general physiological requirements (10 mg/kg DM; National Research Council (NRC), 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Hepatic toxicity, -E-mail: garcia.vaquero@usc.es 1435 caused by Cu overload, is hypothesized to result from redox properties of Cu and is connected with the formation of ROS (Britton, 1996;Luza and Speisky, 1996). ROS are highly reactive and are capable of damaging all biological macromolecules like proteins, lipids and DNA (Grune et al, 1995) that can lead to apoptosis (Wä tjen and Beyersmann, 2004;Banasik et al, 2005;Xu et al, 2006).Traditionally, cattle were thought to be relatively tolerant to Cu accumulation and as Cu deficiency is considered one of the main nutritional disorders in grazing cattle (Ramirez et al, 1998) (Suttle, 2010); but also other minerals such as iron (Fe) and zinc (Zn) (Kendall et al, 2001). However, in recent years an increase in the number of episodes of Cu toxicity has been reported in cattle reared under intensive systems (Bidewell et al, 2000;VLA, 2001).…”

mentioning

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Histochemistry evaluation of the oxidative stress and the antioxidant status in Cu-supplemented cattle

García‐Vaquero

Benedito

López‐Alonso

et al. 2012

Animal

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The aim of this paper is to evaluate at a histopathological level the effect of the most commonly used copper (Cu) supplementation (15 mg/kg dry matter (DM)) in the liver of intensively reared beef cattle. This was done by a histochemistry evaluation of (i) the antioxidant capacity in the liver -by the determination of metallothioneins (MT) and superoxide dismutase (SOD) expression -as well as (ii) the possible induction of oxidative damage -by the determination of inducible nitric oxide synthase (iNOS), nitrotyrosine (NITT), malondialdehyde (MDA) and 8-oxoguanine (8-oxo) -that (iii) could increase apoptotic cell death -determined by cytochrome-c (cyto-c), caspase 1 (casp1) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL). Liver samples from Cu-supplemented (15 mg Cu sulphate/kg DM, n 5 5) and non-supplemented calves (n 5 5) that form part of other experiments to evaluate Cu status were collected at slaughter and processed for immunohistochemistry and TUNEL. MT expression was diffuse and SOD showed slight changes although without statistical significance. iNOS and NITT positive (1) cells significantly increased, mainly around the central veins in the animals from the Cu-supplemented group, whereas no differences were appreciated for the rest of the oxidative stress and apoptosis markers. Under the conditions of this study, which are the conditions of the cattle raised in intensive systems in NW Spain and also many European countries, routinely Cu supplementation increased the risk of the animals to undergo subclinical Cu toxicity, with no significant changes in the Cu storage capacity and the antioxidant defensive system evaluated by MT and SOD expression, but with a significant and important increase of oxidative damage measured by iNOS and NITT. The results of this study indicated that iNOS and NITT could be used as early markers of initial pathological changes in the liver caused by Cu supplementation in cattle, although more studies in cattle under different levels of Cu supplementation are needed.Keywords: cattle, copper, subclinical toxicity, oxidative stress, antioxidant defense ImplicationsThis study demonstrates an increased oxidative damage (measured by a significant increase of the markers inducible nitric oxide synthase (iNOS) and nitrotyrosine (NITT)) in the liver of intensively reared beef cattle receiving moderate copper (Cu) supplementation. This oxidative damage could be considered as the initial pathological change in the animal before further damage will occur, and thus, the markers iNOS and NITT could be used as early indicators of subclinical Cu toxicity in cattle under these nutritional conditions. IntroductionCopper (Cu) is an essential metal associated with several enzymes (either as a co-factor or as an allosteric component) that acts as an electron transfer intermediate in redox reactions (Uauy et al., 1998) therefore being vital for the normal function of the organisms. Cu in the liver is accumulated bound to metallothioneins (MT), proteins involved in the detox...

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Effects of Zinc Supplementation During In Vitro Maturation on Meiotic Maturation of Oocytes and Developmental Capacity in Yak

Xiong

Lan

et al. 2017

Biol Trace Elem Res

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Zinc (Zn) is an essential trace element that is required during mammalian developmental processes. The objective of this study was to investigate the effects of Zn supplementation during in vitro maturation (IVM) on the developmental capacity of yak (Bos grunniens) oocytes. Cumulus expansion, nuclear maturation, intracellular glutathione (GSH), reactive oxygen species (ROS) levels, superoxide dismutase (SOD) activity, subsequent embryonic development, and the expression of Zn transporters (ZnTs) and Zrt and Irt-like proteins (ZiPs) were evaluated. The Zn concentrations in yak plasma and follicular fluid were 0.740 ± 0.012 and 0.382 ± 0.009 μg/mL, respectively. The cumulus expansion did not show significant differences in COCs after matured with or without Zn supplementation (P > 0.05). The intracellular GSH was higher in oocytes matured with 1 or 2 mg/L Zn than in control group (0 mg/L) (P < 0.05). However, ROS levels of oocytes matured with 1 or 2 mg/L Zn were reduced significantly compared with the control and 0.5 mg/L groups (P < 0.05). The SOD activity was increased significantly after Zn supplementation. The cleavage rate was not significantly different after Zn supplementation (P > 0.05). Percentages of matured oocytes that developed into the blastocyst stage after IVF were 47.9, 50.5, 60.4, and 58.9% for 0, 0.5, 1, and 2 mg/L Zn groups, respectively. Gene expression analysis revealed that the expression patterns associated with Zn were changed after Zn supplementation. In conclusion, Zn supplementation to IVM improved yak oocyte maturation and subsequent development by increasing GSH and SOD activity, decreasing ROS in oocytes.

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Cattle hypocuprosis in Argentina associated with periodically flooded soils

Cited by 20 publications

References 3 publications

Selenium supplementation during in vitro maturation enhances meiosis and developmental capacity of yak oocytes

Selenium supplementation during in vitro maturation enhances meiosis and developmental capacity of yak oocytes

Histochemistry evaluation of the oxidative stress and the antioxidant status in Cu-supplemented cattle

Effects of Zinc Supplementation During In Vitro Maturation on Meiotic Maturation of Oocytes and Developmental Capacity in Yak

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