Cattle and Nematodes Under Global Change: Transmission Models as an Ally

Verschave, Sien; Charlier, Johannes; Rose, Hannah; Claerebout, Edwin; Morgan, Eric R.

doi:10.1016/j.pt.2016.04.018

Cited by 41 publications

(26 citation statements)

References 110 publications

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“…To circumvent the high costs and logistic and animal welfare constraints associated with vaccine trials, modelling vaccine efficacy would be an invaluable tool to help define levels of efficacy required and to model integrated use of vaccines with other parasite control measures, such as targeted selective treatments. A recent review addressed how transmission models can help deal with changing parasite epidemiology and support sustainable and effective worm control in cattle; the utility of GIN vaccines as part of future integrated helminth control programmes now needs to be introduced into these models.…”

Section: Discussionmentioning

confidence: 99%

Progress in the development of subunit vaccines for gastrointestinal nematodes of ruminants

Matthews

Geldhof

Tzelos

et al. 2016

Parasite Immunology

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SummaryThe global increase in anthelmintic resistant nematodes of ruminants, together with consumer concerns about chemicals in food, necessitates the development of alternative methods of control for these pathogens. Subunit recombinant vaccines are ideally placed to fill this gap. Indeed, they are probably the only valid option for the long-term control of ruminant parasitic nematodes given the increasing ubiquity of multidrug resistance in a range of worm species across the world. The development of a subunit multicellular parasite vaccine to the point of practical application would be a groundbreaking step in the control of these important endemic infections of livestock. This review summarizes the current status of subunit vaccine development for a number of important gastrointestinal nematodes of cattle and sheep, with a focus on the limitations and problems encountered thus far, and suggestions as to how these hurdles might be overcome. K E Y W O R D Sgastrointestinal nematodes, ruminants, vaccines

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Section: Discussionmentioning

confidence: 99%

Progress in the development of subunit vaccines for gastrointestinal nematodes of ruminants

Matthews

Geldhof

Tzelos

et al. 2016

Parasite Immunology

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“…In contrast, helminth transmission models can be a useful tool for evaluating different scenarios in silico, and to select the most promising (combinations of) control methods for field testing. 41,42 Barnes and colleagues 43 modeled the population dynamics of Trichostrongylus colubriformis in sheep to predict the effect of different vaccines on worm population dynamics in grazing lambs. They concluded that, with vaccines based on conventional antigens, substantial benefits can be obtained with a decrease of 60% in larval establishment in 80% of the flock.…”

Section: Vaccination and Other Worm Control Measuresmentioning

confidence: 99%

Helminth Vaccines in Ruminants

Claerebout

Geldhof

2020

Veterinary Clinics of North America: Food Animal Practice

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KEYWORDS Gastrointestinal nematodes Lungworm Liver fluke Vaccines KEY POINTSOnly a few vaccines against parasitic helminths of livestock are currently on the market; namely those against Dictyocaulus viviparus in cattle, Haemonchus contortus in sheep, and the tapeworm Echinococcus granulosus in sheep.Research is ongoing to develop vaccines based on purified or recombinantly expressed worm proteins for Ostertagia ostertagi and Cooperia oncophora in cattle, for Teladorsagia circumcincta and H contortus in sheep, and for Fasciola hepatica in ruminants. Recombinant expression of worm antigens with the correct conformation to induce protective immunity is still a major challenge in vaccine development. Vaccination is likely to be part of integrated worm control, together with other control measures, such as anthelmintic treatments, biological control, and grazing management. Interdisciplinary research, including social sciences, should investigate drivers of farmers' and veterinarians' decision making, to optimize uptake of vaccination by the end users.Vet Clin Food Anim 36 (2020) 159-171

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“…Potentially, sensors could also be placed in housing or milking facilities to detect pathogens or biomarkers directly in faeces or milk (Neethirajan, 2017). For pasture-borne helminth infections, sensor networks could detect weather and environmental conditions on pastures, which combined with predictive transmission models of parasitic disease, can alert producers when pasture infectivity levels exceed certain thresholds (Verschave et al 2016).…”

Section: Translation Of New Diagnostic Technologies To Manage Parasitmentioning

confidence: 99%

Control of helminth ruminant infections by 2030

Charlier²,

et al. 2018

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Helminth infections have large negative impacts on production efficiency in ruminant farming systems worldwide, and their effective management is essential if livestock production is to increase to meet future human needs for dietary protein. The control of helminths relies heavily on routine use of chemotherapeutics, but this approach is unsustainable as resistance to anthelmintic drugs is widespread and increasing. At the same time, infection patterns are being altered by changes in climate, land-use and farming practices. Future farms will need to adopt more efficient, robust and sustainable control methods, integrating ongoing scientific advances. Here, we present a vision of helminth control in farmed ruminants by 2030, bringing to bear progress in: (1) diagnostic tools, (2) innovative control approaches based on vaccines and selective breeding, (3) anthelmintics, by sustainable use of existing products and potentially new compounds, and (4) rational integration of future control practices. In this review, we identify the technical advances that we believe will place new tools in the hands of animal health decision makers in 2030, to enhance their options for control and allow them to achieve a more integrated and sustainable approach to helminth control in support of animal welfare and production.

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Cattle and Nematodes Under Global Change: Transmission Models as an Ally

Cited by 41 publications

References 110 publications

Progress in the development of subunit vaccines for gastrointestinal nematodes of ruminants

Progress in the development of subunit vaccines for gastrointestinal nematodes of ruminants

Helminth Vaccines in Ruminants

Control of helminth ruminant infections by 2030

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