Cattienoids A–C, three novel steroids from the mushroom Tomophagus cattienensis

Hiền, Bùi Thị Thu; Hoa, Le Thi Phuong; Thắm, Lê Xuân; Quang, Đặng Ngọc

doi:10.1016/j.fitote.2013.08.020

Cited by 20 publications

(14 citation statements)

References 6 publications

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“…The natural product thunberginol F and its derivatives exhibit anti‐allergic and anti‐microbial effects –. The steroid cattienoid B displays cytotoxicity against KB (a human epidermal carcinoma) cells, which is isolated from fruiting bodies of Tomophagus cattienensis . In addition, these special skeletons are useful and versatile building blocks, and key intermediates in the field of organic synthesis…”

Section: Figurementioning

confidence: 99%

Iridium‐Catalyzed Cycloisomerization of Alkynoic Acids: Synthesis of Unsaturated Lactones

et al. 2019

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The iridium‐catalyzed cycloisomerization of various alkynoic acids was successfully developed, and a series of five‐, six‐, and especially seven‐membered unsaturated lactones were constructed with moderate yields and excellent regioselectivities (up to 68% yield, >99:1 rr). In addition, the indole compound can be easily prepared with 75% yield through this efficient synthetic methodology. Moreover, a plausible mechanism for this Ir‐catalyzed cycloisomerization of alkynoic acids was proposed.

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Section: Figurementioning

confidence: 99%

Iridium‐Catalyzed Cycloisomerization of Alkynoic Acids: Synthesis of Unsaturated Lactones

et al. 2019

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“…The least oxygenated compound, 38, has been previously isolated from Ganoderma colossus, 6,11 Ganoderma sp., 10 and Tomophagus cattienensis. 8 However, it was wrongly reported as schisanlactone A, a constituent of the higher plant Schisandra sp., whose structure was determined by X-ray crystallographic analysis as the C-22 epimer (22R isomer) of 38. 12 NMR data of compound 38 (in CDCl 3 ), isolated in the present work, were different from those of schisanlactone A; however, the data for the C-20−C-27 side chains were very similar to those of several other known co-metabolites found in the present study (22S isomers), including colossolactone G (33).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Tomophagus cattienensis is a recently described species, 7 with only one report of a chemical investigation, i.e., the isolation of cattienoids A−C and side-chain fragmented modified lanostanes. 8 As part of our research on the utilization of fungal resources in Thailand, we have recently investigated several Ganoderma species that are taxonomically close to G. lucidum with respect to basidiome morphology and phylogeny. These studies have resulted in the isolation of lanostane triterpenoids from mycelial cultures, and many of them exhibited antimalarial and antitubercular activities.…”

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Highly Modified Lanostane Triterpenes from Fruiting Bodies of the Basidiomycete Tomophagus sp.

et al. 2019

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Thirty-one highly modified lanostanes (1–31), together with 19 known compounds (32–50), were isolated from fruiting bodies of the wood-rot basidiomycete Tomophagus sp. The structures were elucidated by analyses of HRMS and NMR spectroscopic data. The present work demonstrates the high structural diversity of modified lanostane triterpenoids from Tomophagus. This paper also discusses structural revisions of several known derivatives. Some of the isolated compounds exhibited moderate antimalarial activity against Plasmodium falciparum K1 (IC50 5.1–19 μM).

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“…Therefore, members of this genus may be potential candidates to be used as medicines. For example, Tomophagus cattienensis has been shown to contain many rare bioactive compounds, especially cattienoid B which can kill epithelium cancer cells (Hien et al, 2013). A recent study has reported several new lanostane triterpene lactones from the cultivated T. colossus strain (El Dine et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Studies on the Biological Characteristics of the Bt116 Lingzhi Mushroom Strain (Tomophagus sp.) Collected in Hanoi

Tran

Ngo

et al. 2018

VJAS

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In this study, an unknown mushroom species collected on rotting trunks of Ficus elastica in the Hanoi Botanical Garden was investigated. It was designated as Bt116. Based on the observed morphological characteristics, such as irregularly semi-circular, slightly yellow pileus; very soft, homogeneous, spongy, creamy white context; short and not clear stipes; and basidiospores typical of ganoderma mushrooms, etc., we hypothesized that Bt116 belongs to the Tomophagus Murr. mushroom genus. Some biological characteristics of the Bt116 strain were made. The results indicated that the temperature 35°C was optimal for Bt116 mycelial growth; an alkaline environment (pH 8.0) was conducive for the mycelial growth of Bt116 among a range of pH levels from 4.0 to 9.0; aerobic conditions were better than anaerobic conditions for the growth of Bt116 mycelium; and lighting time showed no significant effects on the growth of Bt116 mycelium.

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Cattienoids A–C, three novel steroids from the mushroom Tomophagus cattienensis

Cited by 20 publications

References 6 publications

Iridium‐Catalyzed Cycloisomerization of Alkynoic Acids: Synthesis of Unsaturated Lactones

Iridium‐Catalyzed Cycloisomerization of Alkynoic Acids: Synthesis of Unsaturated Lactones

Highly Modified Lanostane Triterpenes from Fruiting Bodies of the Basidiomycete Tomophagus sp.

Studies on the Biological Characteristics of the Bt116 Lingzhi Mushroom Strain (Tomophagus sp.) Collected in Hanoi

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