Cats, Frogs, and Snakes

Obladen, Michael

doi:10.1177/0883073811411191

Cited by 13 publications

(3 citation statements)

References 42 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NTDs rank amongst the commonest of birth defects, alongside congenital heart anomalies and genito-urinary defects 3 . NTDs have a long history: reports of fetuses and infants with anencephaly, myelomeningocele and craniorachischisis extend back to Ancient Egyptian times 4 . Moreover, throughout the past 60 years, a striking progression of diverse bio-medical advances has impacted the NTD field, meaning that this topic has rarely been ‘out of the news’.…”

Section: Introductionmentioning

confidence: 99%

Neural tube defects: recent advances, unsolved questions, and controversies

Copp¹,

Stanier²,

Greene³

2013

The Lancet Neurology

586

440

View full text Add to dashboard Cite

Neural tube defects (NTDs) are severe congenital malformations affecting around 1 in every 1000 pregnancies. Here we review recent advances and currently unsolved issues in the NTD field. An innovation in clinical management has come from the demonstration that closure of open spina bifida lesions in utero can diminish neurological dysfunction in children. Primary prevention by folic acid has been enhanced through introduction of mandatory food fortification in some countries, although not yet in UK. Genetic predisposition comprises the majority of NTD risk, and genes that regulate folate one-carbon metabolism and planar cell polarity have been strongly implicated. The sequence of human neural tube closure events remains controversial, but study of mouse NTD models shows that anencephaly, open spina bifida and craniorachischisis result from failure of primary neurulation, while skin-covered spinal dysraphism results from defective secondary neurulation. Other 'NTD' malformations, such as encephalocele, are likely to be postneurulation disorders.

show abstract

Section: Introductionmentioning

confidence: 99%

Neural tube defects: recent advances, unsolved questions, and controversies

Copp¹,

Stanier²,

Greene³

2013

The Lancet Neurology

586

440

View full text Add to dashboard Cite

show abstract

“…However, the etiology of NTD has not been clarified. It has been reported that many factors may lead to the development of NTD, including maternal exposure to hyperthermia and various chemicals during pregnancy, drug use, malnutrition or being obese, low folic acid levels, the presence of diabetes in the mother, and genetic factors (8).…”

Section: Introductionmentioning

confidence: 99%

Effect of Zuclopenthixol Acetate on Neural Tube Development in Early Chick Embryos

ALBAŞ KURT,

SARITAŞ,

ATAY

et al. 2023

Clinical and Experimental Health Sciences

View full text Add to dashboard Cite

Objective: Neural tube defects are one of the congenital malformations of the central nervous system. Although the factors that cause the development of neural tube defects and their mechanisms of action are still not clearly explained, genetic predisposition, drug use and some environmental factors are thought to play a role. In this study, it was aimed to investigate the effects of zuclopenthixol acetate (ZA) on neural tube development in a chick embryo model. Methods: Fourty specific pathogen-free (SPF) eggs were used in the study. The eggs were incubated for 28 hours and divided into four groups of 10 eggs each. At the end of the 28th hours, saline was injected to the control group, while ZA was administered subblastodermically to the experimental groups in 3 different doses (0.7, 1.4, 2.1 mg/kg). At the end of the 48th hours, all the eggs were opened and the embryos were dissected from the embryonic membranes and evaluated morphologically and histopathologically. Results: When the study groups were evaluated according to the neural tube positions (open or closed), it was found that the neural tube patency increased depending on the ZA dose, which was statistically significant (p < 0.05). In addition, morphological developments of embryos were evaluated. Compared to the control group, a statistically significant decrease was observed in the mean somite numbers in all ZA-treated groups, while a significant decrease was found in the mean cranio-caudal length only in the high-dose group. Conclusion: In this study, it was observed that neural tube and morphological development were adversely affected in the groups treated with ZA in the chick embryo model. It was shown that neural tube closure defects in embryos increased in direct proportion with ZA doses. However, we believe that it will not be possible to fully adapt the results of this study, which was carried out in the chick embryo model, to humans and that more comprehensive research should be conducted.

show abstract

“…Historical recordings of neural tube defects date back to the ancient Egyptian periods, which could be explained by the unmistakable clinical features observed in fetuses and infants [ 9 ]. The clinical features of NTDs vary greatly.…”

Section: Introduction—inborn Errors Of Development: Neural Tube Dementioning

confidence: 99%

Neural Tube Defects: From a Proteomic Standpoint

Puvirajesinghe

Borg

2015

Metabolites

View full text Add to dashboard Cite

Neural tube defects (NTDs) are congenital birth defects classified according to their resulting morphological characteristics in newborn patients. Current diagnosis of NTDs relies largely on the structural evaluation of fetuses using ultrasound imaging, with biochemical characterization used as secondary screening tools. The multigene etiology of NTDs has been aided by genetic studies, which have discovered panels of genes mutated in these diseases that encode receptors and cytoplasmic signaling molecules with poorly defined functions. Animal models ranging from flies to mice have been used to determine the function of these genes and identify their associated molecular cascades. More emphasis is now being placed on the identification of biochemical markers from clinical samples and model systems based on mass spectrometry, which open novel avenues in the understanding of NTDs at protein, metabolic and molecular levels. This article reviews how the use of proteomics can push forward the identification of novel biomarkers and molecular networks implicated in NTDs, an indispensable step in the improvement of patient management.

show abstract

Cats, Frogs, and Snakes

Cited by 13 publications

References 42 publications

Neural tube defects: recent advances, unsolved questions, and controversies

Neural tube defects: recent advances, unsolved questions, and controversies

Effect of Zuclopenthixol Acetate on Neural Tube Development in Early Chick Embryos

Neural Tube Defects: From a Proteomic Standpoint

Contact Info

Product

Resources

About