Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations

Jäntti, Jiri; Joenathan, Anisha; Fugazzola, Maria; Tuppurainen, Juuso; Honkanen, Juuso T.J.; Töyräs, Juha; van Weeren, René; Snyder, Brian D.; Grinstaff, Mark W.; Matikka, Hanna; Mäkelä, Janne T.A.

doi:10.1016/j.joca.2023.11.020

Osteoarthritis and Cartilage

2024

DOI: 10.1016/j.joca.2023.11.020

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Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations

Jiri Jäntti,

Anisha Joenathan,

Maria Fugazzola

et al.

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2024

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Cited by 2 publications

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Measurement of T_1ρ dispersion with compressed sensing and magnetization prepared radial balanced steady‐state free precession in spontaneous human osteoarthritis

Pala,

Paajanen,

Ristaniemi

et al. 2024

Magnetic Resonance in Med

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PurposeTo assess the potential for accelerating continuous‐wave (CW) T1ρ dispersion measurement with compressed sensing approach via studying the effect that the data reduction has on the ability to detect differences between intact and degenerated articular cartilage with different spin‐lock amplitudes and to assess quantitative bias due to acceleration.MethodsOsteochondral plugs (n = 27, 4 mm diameter) from femur (n = 14) and tibia (n = 13) regions from human cadaver knee joints were obtained from commercial biobank (Science Care, USA) under Ethical permission 134/2015. MRI of specimens was performed at 9.4T with magnetization prepared radial balanced SSFP (bSSFP) readout sequence, and the CWT1ρ relaxation time maps were computed from the measured data. The relaxation time maps were evaluated in the cartilage zones for different acceleration factors. For reference, Osteoarthritis Research Society International (OARSI) grading and biomechanical measurements were performed and correlated with the MRI findings.ResultsFour‐fold acceleration of CWT1ρ dispersion measurement by compressed sensing approach was feasible without meaningful loss in the sensitivity to osteoarthritic (OA) changes within the articular cartilage. Differences were significant between intact and OA groups in the superficial and transitional zones, and CWT1ρ correlated moderately with the reference measurements (0.3 < r < 0.7).ConclusionCWT1ρ was able to differentiate between intact and OA cartilage even with four‐fold acceleration. This indicates that acceleration of CWT1ρ dispersion measurement by compressed sensing approach is feasible with negligible loss in the sensitivity to osteoarthritic changes in articular cartilage.

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Measurement of T_1ρ dispersion with compressed sensing and magnetization prepared radial balanced steady‐state free precession in spontaneous human osteoarthritis

Pala,

Paajanen,

Ristaniemi

et al. 2024

Magnetic Resonance in Med

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Revealing Detailed Cartilage Function Through Nanoparticle Diffusion Imaging: A Computed Tomography & Finite Element Study

Tuppurainen,

Paakkari,

Jäntti

et al. 2024

Ann Biomed Eng

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The ability of articular cartilage to withstand significant mechanical stresses during activities, such as walking or running, relies on its distinctive structure. Integrating detailed tissue properties into subject-specific biomechanical models is challenging due to the complexity of analyzing these characteristics. This limitation compromises the accuracy of models in replicating cartilage function and impacts predictive capabilities. To address this, methods revealing cartilage function at the constituent-specific level are essential. In this study, we demonstrated that computational modeling derived individual constituent-specific biomechanical properties could be predicted by a novel nanoparticle contrast-enhanced computer tomography (CECT) method. We imaged articular cartilage samples collected from the equine stifle joint (n = 60) using contrast-enhanced micro-computed tomography (µCECT) to determine contrast agents’ intake within the samples, and compared those to cartilage functional properties, derived from a fibril-reinforced poroelastic finite element model. Two distinct imaging techniques were investigated: conventional energy-integrating µCECT employing a cationic tantalum oxide nanoparticle (Ta2O5-cNP) contrast agent and novel photon-counting µCECT utilizing a dual-contrast agent, comprising Ta2O5-cNP and neutral iodixanol. The results demonstrate the capacity to evaluate fibrillar and non-fibrillar functionality of cartilage, along with permeability-affected fluid flow in cartilage. This finding indicates the feasibility of incorporating these specific functional properties into biomechanical computational models, holding potential for personalized approaches to cartilage diagnostics and treatment.

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Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations

Cited by 2 publications

References 21 publications

Measurement of T_1ρ dispersion with compressed sensing and magnetization prepared radial balanced steady‐state free precession in spontaneous human osteoarthritis

Measurement of T_1ρ dispersion with compressed sensing and magnetization prepared radial balanced steady‐state free precession in spontaneous human osteoarthritis

Revealing Detailed Cartilage Function Through Nanoparticle Diffusion Imaging: A Computed Tomography & Finite Element Study

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Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations

Cited by 2 publications

References 21 publications

Measurement of T1ρ dispersion with compressed sensing and magnetization prepared radial balanced steady‐state free precession in spontaneous human osteoarthritis

Measurement of T1ρ dispersion with compressed sensing and magnetization prepared radial balanced steady‐state free precession in spontaneous human osteoarthritis

Revealing Detailed Cartilage Function Through Nanoparticle Diffusion Imaging: A Computed Tomography & Finite Element Study

Contact Info

Product

Resources

About

Measurement of T_1ρ dispersion with compressed sensing and magnetization prepared radial balanced steady‐state free precession in spontaneous human osteoarthritis

Measurement of T_1ρ dispersion with compressed sensing and magnetization prepared radial balanced steady‐state free precession in spontaneous human osteoarthritis