Cationic Polydiacetylene Micelles for Gene Delivery

Morin, Emmanuelle; Nothisen, Marc; Wagner, Alain; Rémy, Jean-Serge

doi:10.1021/bc200083p

Cited by 31 publications

(28 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the various crosslinking approaches, the utilization of photo‐crosslinking is of particular importance because it is a clean resource and can be easily manipulated and applied in a spatial and temporal manner . To achieve such photoinitiated crosslinking, the most commonly used approaches in drug delivery systems are the diacetylene‐based amphiphiles with double bonds . Among these polymers containing double bonds, a cinnamate‐containing polymer is frequently used as a photo‐crosslinker because the cinnamyl group is light‐sensitive and has excellent biocompatible properties .…”

Section: Introductionmentioning

confidence: 99%

A Nanoplatform with Precise Control over Release of Cargo for Enhanced Cancer Therapy

Wang

Zhang

et al. 2016

Small

View full text Add to dashboard Cite

The development of a nanocarrier delivery system having both sufficient stability in blood circulation and a rapid drug release profile at target sites remains a major challenge in cancer therapy. Here, a multifunctional star-shaped micellar system with a precisely spatiotemporal control of releasing encapsulated agents is developed by mixing a photoinitiated crosslinking amphiphilic copolymer with a phenylboronic acid (PBA)-functionalized redox-sensitive amphiphilic copolymer for the first time. The combination of the functional polymers effectively resolves the contradiction that the micellar system cannot release the rapid drug release in cells when it possesses an extreme stability that is often required in blood circulation. In this system, the inner core polymers are photo-crosslinked, endowing a stable micelle matrix structure; the end groups of the hydrophilic segments are decorated with PBA ligands, providing an active targeting ability; disulfide bonds in the micellar matrix impart a redox-responsive trigger for the prompt intracellular release of drugs. As a result, with a relatively low DOX dosage (2 mg kg(-1) per injection) the in vivo antitumor effect on H22-bearing BALB/c mice shows that the micelles have a high therapeutic efficacy against solid tumors while minimal side effects against normal tissues.

show abstract

Section: Introductionmentioning

confidence: 99%

A Nanoplatform with Precise Control over Release of Cargo for Enhanced Cancer Therapy

Wang

Zhang

et al. 2016

Small

View full text Add to dashboard Cite

show abstract

“…Typically polymeric micelles are formed from selfaggregation of amphiphilic polymers with the hydrophobic inner core and the hydrophilic outer shell in aqueous media (Kedar et al, 2010) that may be applied as promising carriers for the delivery of drugs (Kataoka et al, 2001;Gaucher et al, 2005;Xun et al, 2011), proteins (Kim et al, 2011) and genes (Morin et al, 2011). As delivery carriers for hydrophobic drugs, the polymeric micelles possess many attractive features and advantages over other types of drug carriers.…”

Section: Introductionmentioning

confidence: 99%

Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system

Songsurang¹,

Siraleartmukul²,

Muangsin³

2015

Journal of Microencapsulation

View full text Add to dashboard Cite

The purpose of this study was to design and characterise an oral mucoadhesive micellar drug carrier. In this regard, a mucoadhesive hydrophobic cationic aminocellulose was easily synthesised under mild homogeneous conditions with high yield. The cellulose derivative resulted in strongly improved mucoadhesive properties but was pH dependent. Furthermore, the hydrophobic anticancer drug camptothecin was successfully encapsulated into the mucoadhesive cellulose derivative micelles with spherical shape stability of 233 nm in diameter and low particle size distribution. The CPT-loaded nanocarriers provided high encapsulation efficiency about 86.4%. In vitro release, CPT-loaded cellulose derivative micelles showed a reduction in release rate compared with physically pure CPT solution. The release results also indicated that a sustained release of CPT to >80% over 4 d for pH 6.8 and 7.4. Therefore, mucoadhesive hydrophobic cationic aminocellulose micelles seem to be a promising carrier for various pharmaceutical applications especially for poorly water-soluble drug delivery system.

show abstract

“…Varying the polar head group, we also studied cationic PDA-based micelles, which showed remarkable gene delivery properties. 3 More recently, Doris et al…”

mentioning

confidence: 99%

Photopolymerized micelles of diacetylene amphiphile: physical characterization and cell delivery properties

et al. 2015

Self Cite

View full text Add to dashboard Cite

A series of polydiacetylene (PDA) - based micelles were prepared from diacetylenic surfactant bearing polyethylene glycol, by increasing UV-irradiation times. These polymeric lipid micelles were analyzed by physicochemical methods, electron microscopy and NMR analysis. Cellular delivery of fluorescent dye suggests that adjusting the polymerization state is vital to reach the full in vitro potential of PDA-based delivery systems.

show abstract

Cationic Polydiacetylene Micelles for Gene Delivery

Cited by 31 publications

References 28 publications

A Nanoplatform with Precise Control over Release of Cargo for Enhanced Cancer Therapy

A Nanoplatform with Precise Control over Release of Cargo for Enhanced Cancer Therapy

Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system

Photopolymerized micelles of diacetylene amphiphile: physical characterization and cell delivery properties

Contact Info

Product

Resources

About