Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity**

Guénin, Erwann; Hervé, Anne-Cécile; Floch, Virginie; Loisel, Séverine; Yaouanc, Jean‐Jacques; Clément, Jean-Claude; Férec, Claude; Abbayes, Hervé des

doi:10.1002/(sici)1521-3773(20000204)39:3<629::aid-anie629>3.0.co;2-k

Cited by 92 publications

(49 citation statements)

References 13 publications

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“…For example, Floch and coworkers demonstrated that use of phosphorus or arsenic atoms instead of nitrogen, which incorporate phosphonate linkers, convey cationic charge and result in improved transfection efficiency and reduced cytotoxicity. 13 …”

Section: Vector Design and Formulationmentioning

confidence: 99%

Overcoming Nonviral Gene Delivery Barriers: Perspective and Future

et al. 2013

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A key end goal of gene delivery research is to develop clinically-relevant vectors that can be used to combat elusive diseases such as AIDS. Despite promising engineering strategies, efficiency and ultimately gene modulation efficacy of nonviral vectors have been hindered by numerous in vitro and in vivo barriers that have resulted in sub-viral performance. In this perspective, we concentrate on the gene delivery barriers associated with the two most common classes of nonviral vectors, cationic-based lipids and polymers. We present the existing delivery barriers and summarize current vector-specific strategies to overcome said barriers.

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Section: Vector Design and Formulationmentioning

confidence: 99%

Overcoming Nonviral Gene Delivery Barriers: Perspective and Future

et al. 2013

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“…Due to the negatively charged surface of bacterial membrane, it is reasoned that the strong polarization effect of phosphorus facilitates QPS to adsorb bacteria. Apart from the enhanced antibacterial activity, QPS‐containing macromolecules possess improved thermal and pH stability as well as higher conductivity as compared with ammonium analogs because of the weaker electronegativity of phosphorus . Furthermore, many researchers have revealed the high flame retardancy of phosphorus‐containing compounds .…”

Section: Introductionmentioning

confidence: 99%

Characterization and antipathogenic evaluation of a novel quaternary phosphonium tripolyacrylamide and elucidation of the inactivation mechanisms

Xue

Xiao

2015

J Biomedical Materials Res

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To mitigate the crisis of pathogen-caused disease outbreaks, developing novel disinfection agents with broad-spectrum antipathogenic performance is a severe task. In this work, an antipathogenic tripolyacrylamide containing aliphatic quaternary phosphonium salt (QPS) was prepared. To confirm the broad-spectrum antipathogenic activity of the as-prepared polymer, the in vitro antibacterial performance was evaluated against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) and viral inactivation was assessed against influenza virus and adenovirus as well. The polymers exhibited higher bactericidal activity against S. aureus than E. coli in terms of minimal inhibitory concentration (MIC), while possessing much lower MIC values compared with their corresponding compound. The morphological alterations in polymer treated E. coli, captured by atomic force microscopy, confirmed the membrane-acting antibacterial mechanism of polymeric QPS. The plaque reduction assay performed on influenza virus and adenovirus demonstrated the as-prepared tripolymer could efficiently inactivate both enveloped and non-enveloped viruses, and the two different antiviral mechanisms were elucidated correspondingly. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 747-757, 2016.

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“…Later, many studies have proven that DOTAP is a feasible and efficient cationic lipid in gene delivery [ 162 , 163 , 164 , 165 ]. Other cationic lipids apart from quaternary ammonium lipids have also been developed through the delocalization of cationic head groups, such as guanidinium lipids, imidazolium lipids, pyridinium lipids, piperidinium lipids, pyrrolidinium lipids, and phosphonium lipids [ 166 , 167 , 168 , 169 , 170 , 171 , 172 ].…”

Section: Modifications Of Lipid-based Nanoparticlesmentioning

confidence: 99%

Modification of Lipid-Based Nanoparticles: An Efficient Delivery System for Nucleic Acid-Based Immunotherapy

Zhang

et al. 2022

Molecules

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Lipid-based nanoparticles (LBNPs) are biocompatible and biodegradable vesicles that are considered to be one of the most efficient drug delivery platforms. Due to the prominent advantages, such as long circulation time, slow drug release, reduced toxicity, high transfection efficiency, and endosomal escape capacity, such synthetic nanoparticles have been widely used for carrying genetic therapeutics, particularly nucleic acids that can be applied in the treatment for various diseases, including congenital diseases, cancers, virus infections, and chronic inflammations. Despite great merits and multiple successful applications, many extracellular and intracellular barriers remain and greatly impair delivery efficacy and therapeutic outcomes. As such, the current state of knowledge and pitfalls regarding the gene delivery and construction of LBNPs will be initially summarized. In order to develop a new generation of LBNPs for improved delivery profiles and therapeutic effects, the modification strategies of LBNPs will be reviewed. On the basis of these developed modifications, the performance of LBNPs as therapeutic nanoplatforms have been greatly improved and extensively applied in immunotherapies, including infectious diseases and cancers. However, the therapeutic applications of LBNPs systems are still limited due to the undesirable endosomal escape, potential aggregation, and the inefficient encapsulation of therapeutics. Herein, we will review and discuss recent advances and remaining challenges in the development of LBNPs for nucleic acid-based immunotherapy.

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Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity**

Cited by 92 publications

References 13 publications

Overcoming Nonviral Gene Delivery Barriers: Perspective and Future

Overcoming Nonviral Gene Delivery Barriers: Perspective and Future

Characterization and antipathogenic evaluation of a novel quaternary phosphonium tripolyacrylamide and elucidation of the inactivation mechanisms

Modification of Lipid-Based Nanoparticles: An Efficient Delivery System for Nucleic Acid-Based Immunotherapy

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