Cationic nanoglycolipidic particles as vector and adjuvant for the study of the immunogenicity of SIV Nef protein

Haij, Nawal Ben; Mzoughi, Olfa; Planès, Rémi; Bahraoui, Elmostafa

doi:10.1016/j.ijpharm.2011.06.049

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…Mannosylated glycolipids have also been used for coating liposomal HIV vaccines. Liposomes containing either peptide sequence from HIV gp120 or SIV GST-Nef protein were functionalized with mannosylated glycolipids and their immunization potential was evaluated [147,148]. Once again, targeted liposomes were associated with better immune response as compared to other controls.…”

Section: Nano-architectures For Hiv Prophylaxismentioning

confidence: 99%

A review of nanotechnological approaches for the prophylaxis of HIV/AIDS

Date

Destache

2013

Biomaterials

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Successful treatment and control of HIV/AIDS is one of the biggest challenges of 21st century. More than 33 million individuals are infected with HIV worldwide and more than 2 million new cases of HIV infection have been reported. The situation demands development of effective prevention strategies to control the pandemic of AIDS. Due to lack of availability of an effective HIV vaccine, antiretroviral drugs and nucleic acid therapeutics like siRNA have been explored for HIV prophylaxis. Clinical trials shave shown that antiretroviral drugs, tenofovir and emtricitabine can offer some degree of HIV prevention. However, complete prevention of HIV infection has not been achieved yet. Nanotechnology has brought a paradigm shift in the diagnosis, treatment and prevention of many diseases. The current review discusses potential of various nanocarriers such as dendrimers, polymeric nanoparticles, liposomes, lipid nanocarriers, drug nanocrystals, inorganic nanocarriers and nanofibers in improving efficacy of various modalities available for HIV prophylaxis.

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Section: Nano-architectures For Hiv Prophylaxismentioning

confidence: 99%