Cationic nanoemulsions with prolonged retention time as promising carriers for ophthalmic delivery of tacrolimus

Zhang, Jialiang; Liu, Zhihong; Tao, Chun; Lin, Xianqing; Zhang, Minxin; Zeng, Liang; Xu, Chunxiao; Hong-tao, Song

doi:10.1016/j.ejps.2020.105229

Cited by 35 publications

(15 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increasing efficiency of lipid-based nanocarriers over the last years has made them a target for constant and thorough research. In fact, these formulations have been already used in both preclinical and clinical practice demonstrating favorable outcomes treating ocular diseases [ 10 , 11 , 16 , 51 , 87 , 91 , 98 , 103 , 126 , 131 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 ]. With all these promising results and taking advantage of the new technologies, researchers, pharmacists, and clinical professionals must continue this line of investigation and encourage the use of these new formulations in the near future in clinical medical practice.…”

Section: Discussionmentioning

confidence: 99%

Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases

et al. 2021

View full text Add to dashboard Cite

Effective drug delivery to intraocular tissues remains a great challenge due to complex anatomical and physiological barriers that selectively limit the entry of drugs into the eye. To overcome these challenges, frequent topical application and regular intravitreal injections are currently used to achieve the desired drug concentrations into the eye. However, the repetitive installation or recurrent injections may result in several side effects. Recent advancements in the field of nanoparticle-based drug delivery have demonstrated promising results for topical ophthalmic nanotherapies in the treatment of intraocular diseases. Studies have revealed that nanocarriers enhance the intraocular half-life and bioavailability of several therapies including proteins, peptides and genetic material. Amongst the array of nanoparticles available nowadays, lipid-based nanosystems have shown an increased efficiency and feasibility in topical formulations, making them an important target for constant and thorough research in both preclinical and clinical practice. In this review, we will cover the promising lipid-based nanocarriers used in topical ophthalmic formulations for intraocular drug delivery.

show abstract

Section: Discussionmentioning

confidence: 99%

Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Poloxamer 188 (a non-ionic emulsifier) was used as a co-emulsifier to reduce the size distribution [29]. Conjugation of tween 80 and poloxamer 188 is reported to improve the spreading over the entire cornea-conjunctiva surface [30].…”

Section: Resultsmentioning

confidence: 99%

Mono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading of Steroidal Drug: 32 Factorial Design and Physicochemical Characterization

et al. 2021

View full text Add to dashboard Cite

Oil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, increasing the drug absorption. Triamcinolone acetonide (TA) is one of the first pharmacologic strategies applied as an intravitreal injection in the treatment of age-related macular degeneration (AMD). Newly synthesized quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and quinuclidine surfactants have been screened with the purpose to select the best compound to formulate long-term stable NEs that combine the best physicochemical properties for the loading of TA intended for ocular administration.

show abstract

“… 28 Similarly, increased therapeutic efficacy and greater drug concentration in aqueous humor (as compared to commercial products) were reported for nanoemulsions containing dorzolamide hydrochloride, 29 acetazolamide, 30 moxifloxacin, 31 terbinafine hydrochloride, 32 and tacrolimus. 33 …”

Section: Introductionmentioning

confidence: 99%

Ophthalmic Nanoemulsions: From Composition to Technological Processes and Quality Control

et al. 2021

View full text Add to dashboard Cite

Nanoemulsions are considered as the most promising solution to improve the delivery of ophthalmic drugs. The design of ophthalmic nanoemulsions requires an extensive understanding of pharmaceutical as well as technological aspects related to the selection of excipients and formulation processes. This Review aims at providing the readers with a comprehensive summary of possible compositions of nanoemulsions, methods for their formulation (both laboratory and industrial), and differences between technological approaches, along with an extensive outline of the research methods enabling the confirmation of in vitro properties, pharmaceutical performance, and biological activity of the obtained product. The composition of the formulation has a major influence on the properties of the final product obtained with low-energy emulsification methods. Increasing interest in high-energy emulsification methods is a consequence of their scalability important from the industrial perspective. Considering the high-energy emulsification methods, both the composition and conditions of the process (e.g., device power level, pressure, temperature, homogenization time, or number of cycles) are important for the properties and stability of nanoemulsions. It is advisible to determine the effect of each parameter on the quality of the product to establish the optimal process parameters’ range which, in turn, results in a more reproducible and efficient production.

show abstract

Cationic nanoemulsions with prolonged retention time as promising carriers for ophthalmic delivery of tacrolimus

Cited by 35 publications

References 34 publications

Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases

Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases

Mono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading of Steroidal Drug: 32 Factorial Design and Physicochemical Characterization

Ophthalmic Nanoemulsions: From Composition to Technological Processes and Quality Control

Contact Info

Product

Resources

About