Cationic liposomes in double emulsions for controlled release

Wang, Qing; Rojas, Edith C.; Papadopoulos, Kyriakos

doi:10.1016/j.jcis.2012.06.036

Cited by 15 publications

(3 citation statements)

References 45 publications

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“…Based on a study reported by Liu et al, the encapsulation efficiency of lactoferrin (a positively charged protein) and albumin (a negatively charged protein) in anionic liposomes was approximately 46.7% and 33.6%, respectively [66,67]. Furthermore, Wang et al reported that liposomes that are cationized by the presence of 1,2-dioleoyl-3-trimethylammonium-propane had a higher encapsulation efficiency for albumin compared to neutral liposomes [68]. These reports suggest that the encapsulation efficiency for a protein increases when it is encapsulated into a liposome with an oppositely charged lipid membrane due to electrostatic interactions between the protein and the liposomal membrane.…”

Section: Lipid Membranesmentioning

confidence: 99%

When Albumin Meets Liposomes: A Feasible Drug Carrier for Biomedical Applications

et al. 2021

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Albumin, the most abundant protein in plasma, possesses some inherent beneficial structural and physiological characteristics that make it suitable for use as a drug delivery agent, such as an extraordinary drug-binding capacity and long blood retention, with a high biocompatibility. The use of these characteristics as a nanoparticle drug delivery system (DDS) offers several advantages, including a longer circulation time, lower toxicity, and more significant drug loading. To date, many innovative liposome preparations have been developed in which albumin is involved as a DDS. These novel albumin-containing liposome preparations show superior deliverability for genes, hydrophilic/hydrophobic substances and proteins/peptides to the targeting area compared to original liposomes by virtue of their high biocompatibility, stability, effective loading content, and the capacity for targeting. This review summarizes the current status of albumin applications in liposome-based DDS, focusing on albumin-coated liposomes and albumin-encapsulated liposomes as a DDS carrier for potential medical applications.

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Section: Lipid Membranesmentioning

confidence: 99%

When Albumin Meets Liposomes: A Feasible Drug Carrier for Biomedical Applications

et al. 2021

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“…It was additionally reported that the dispersibility of liposomes following the addition of DOTAP was more effective than without DOTAP due to the presence of electrostatic forces 25 . Furthermore, another study stated that adding DOTAP can render liposomes spherical with an approximate size of 100 nm 15 .…”

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confidence: 99%

The effect of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) Addition on the physical characteristics of β-ionone liposomes

Miatmoko

Asmoro

Azhari

et al. 2023

Sci Rep

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Abstractβ-ionone (ION) is a cyclic terpenoid compound that demonstrates considerable potential for the prevention and treatment of cancer. However, the water solubility of β-ionone is poor and the compound demonstrates low permeability. Liposomes have been reported as increasing both qualities. In this study, the development of β-ionone liposomes was initiated by adding 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) to produce cationic liposomes as a means of enhancing binding to cancer cells. Liposomes composed of β-ionone, HSPC, cholesterol, and DSPE-mPEG2000 were prepared using the thin layer hydration method. Cellular uptake studies were carried out with HeLa cells incubated with β-ionone liposomes for two hours. The results indicated that the addition of DOTAP increased particle size and affected the spectroscopical and thermogram profiles of the liposomes, thereby confirming reduction in liposome crystallinity, while the zeta potential became positive. Moreover, the calcein release profile further showed that additional DOTAP increased both membrane fluidity and cellular uptake in HeLa cells In conclusion, adding DOTAP affected the physicochemical cationic properties of liposome and improved cellular uptake in HeLa cells.

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“…The 120 liposome-in-emulsion system successfully eradicated tumours in 121 rabbits and created a depot effect thereby leading to the require-122 ment for fewer injections [25]. Recently, the liposomes-in-double [26]. Furthermore, nanoparticles in emulsions have been 126 investigated for orally delivering nucleic acids and showed effec-127 tive gene and siRNA delivery [27].…”

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confidence: 99%

A lipid based multi-compartmental system: Liposomes-in-double emulsion for oral vaccine delivery

Liau

Hook

Prestidge

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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Cationic liposomes in double emulsions for controlled release

Cited by 15 publications

References 45 publications

When Albumin Meets Liposomes: A Feasible Drug Carrier for Biomedical Applications

When Albumin Meets Liposomes: A Feasible Drug Carrier for Biomedical Applications

The effect of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) Addition on the physical characteristics of β-ionone liposomes

A lipid based multi-compartmental system: Liposomes-in-double emulsion for oral vaccine delivery

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