Cationic effect of an ionic copolymer with a temperature-responsive charateristic on the LCST value: A broad LCST spectrum of 35 to 46 °C

Seo, Jae‐Won; Shin, Ueon Sang

doi:10.1007/s13233-015-3143-9

Cited by 10 publications

(3 citation statements)

References 26 publications

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“…Although, the ionic P[VBTP][Cl] homopolymer was reported to show only UCST-type transition in the presence of halide ions in H 2 O Table S1) as obtained from the turbidity curves (Figure S13) indicating their gradual increase with the increasing ionic P[VBTP][Cl] content in the copolymers and they were higher than that (56.9 °C) of nonionic P(OEtOxA), which is in good agreement with the results reported earlier . The heating and cooling turbidity curves for P2 and P3 were identical, indicating negligible hysteresis (Figure S15).…”

Section: Resultssupporting

confidence: 88%

“…49 T cL s were found to be 57.1, 58.4, 61, and 63.8 °C for P1, P2, P3, and P4, respectively, (Table S1) as obtained from the turbidity curves (Figure S13) indicating their gradual increase with the increasing ionic P[VBTP][Cl] content in the copolymers and they were higher than that (56.9 °C) of nonionic P(OEtOxA), which is in good agreement with the results reported earlier. 67 The heating and cooling turbidity curves for P2 and P3 were identical, indicating negligible hysteresis (Figure S15). Surprisingly, P5−P7 copolymers did not show any LCSTtype transition, probably because of high content of ionic P[VBTP][Cl] segments.…”

Section: ■ Results and Discussionmentioning

confidence: 92%

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Poly[oligo(2-ethyl-2-oxazoline)acrylate]-Based Poly(ionic liquid) Random Copolymers with Coexistent and Tunable Lower Critical Solution Temperature- and Upper Critical Solution Temperature-Type Phase Transitions

et al. 2018

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The synthesis of a series of dual thermosensitive nonionic−ionic random copolymers with varying compositions by reversible addition−fragmentation chain transfer polymerization is described. These copolymers contain oligo(2-ethyl-2-oxazoline)acrylate (OEtOxA) and either triphenyl-4-vinylbenzylphosphonium chloride ([VBTP][Cl]) or 3-n-butyl-1-vinylimidazolium bromide ([VBuIm][Br]) ionic liquid (IL) units. The copolymers having low content of ionic poly(ionic liquid) (PIL)) segments show only lower critical solution temperature (LCST)-type phase transition with almost linear increase of their cloud points with increasing percentage of ionic PIL segments. Furthermore, LCST-type cloud points (T cL s) are found very sensitive and tunable with respect to the nature and concentration of halide ions (X − = Cl − , Br − , and I − ) and copolymer compositions. However, copolymers with high content of ionic PIL segments show both LCST-type followed by upper critical solution temperature (UCST)-type phase transitions in the presence of halide ions. Dual LCST-and UCST-type phase behaviors are prominent and repeatable for many heating/cooling cycles. Both types of cloud points are found to be sensitive to copolymer compositions, concentration, and nature and concentration of the halide ions. The phase behaviors of both types of copolymers with a very high ionic content (>90%) are exactly similar to that of P[VBTP] [Cl] or P [VBuIm][Br] homopolymers showing only UCST-type phase transition in the presence of halide ions. The inherent biocompatibility of the P(OEtOxA) segment along with the interesting dual thermoresponsiveness makes these copolymers highly suitable candidates for biomedical applications including drug delivery.

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Section: Resultssupporting

confidence: 88%

Section: ■ Results and Discussionmentioning

confidence: 92%

Poly[oligo(2-ethyl-2-oxazoline)acrylate]-Based Poly(ionic liquid) Random Copolymers with Coexistent and Tunable Lower Critical Solution Temperature- and Upper Critical Solution Temperature-Type Phase Transitions

et al. 2018

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“…151 However, by adjusting the ratio of hydrophobic and hydrophilic groups, the LCST is controllable for desired therapeutic applications. 152 A copolymer of PEI-PNI-PAM was synthesized for thermo-responsive oligonucleotide delivery (Figure 5(A)), and to increase the transition temperature up to 42 ℃, vinylpyrrolidone was introduced in the copolymer as a hydrophilic monomer. 153 When heat was applied, the polymeric carrier with luciferase genes increased the gene expression level by more than 2 orders of magnitude, compared to no heating.…”

Section: Heatmentioning

confidence: 99%

Systematic Combination of Oligonucleotides and Synthetic Polymers for Advanced Therapeutic Applications

et al. 2021

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Nanotechnology in improving medical devices for smart drug delivery

Aguilar

2019

Biomimetic Nanoengineered Materials for Advanced Drug Delivery

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Cationic effect of an ionic copolymer with a temperature-responsive charateristic on the LCST value: A broad LCST spectrum of 35 to 46 °C

Cited by 10 publications

References 26 publications

Poly[oligo(2-ethyl-2-oxazoline)acrylate]-Based Poly(ionic liquid) Random Copolymers with Coexistent and Tunable Lower Critical Solution Temperature- and Upper Critical Solution Temperature-Type Phase Transitions

Poly[oligo(2-ethyl-2-oxazoline)acrylate]-Based Poly(ionic liquid) Random Copolymers with Coexistent and Tunable Lower Critical Solution Temperature- and Upper Critical Solution Temperature-Type Phase Transitions

Systematic Combination of Oligonucleotides and Synthetic Polymers for Advanced Therapeutic Applications

Nanotechnology in improving medical devices for smart drug delivery

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