Cationic Au(I) complexes with aryl-benzothiazoles and their antibacterial activity

Stenger-Smith, Jenny; Chakraborty, Indranil; Mascharak, Pradip K.

doi:10.1016/j.jinorgbio.2018.05.003

Cited by 19 publications

(19 citation statements)

References 29 publications

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“…Recently, the antimicrobial properties of two cationic Au(I) complexes derived from aryl-benzothiazoles: [(PPh 3 )Au(pbt)](OTf) 66 and [(PPh 3 )Au(qbt)](OTf) 67 (pbt = 2-(pyridyl)benzothiazole, qbt = (quinolyl)benzothiazole, and OTf = trifluoromethanesulfonate anion) were described (Figure ). Complexes 66 and 67 showed strong antibacterial effects against the Gram negative bacteria A. baumannii and P.…”

Section: Antibacterial Activity Of Thiazole Derivatives With Unknown ...mentioning

confidence: 99%

Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

et al. 2020

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Thiazoles, their benzofused systems, and thiazolidinone derivatives are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti-inflammatory, anti-HIV, antidiabetic, antitumor, and antimicrobial. In particular, in the past decade, many compounds bearing these heterocycles have been studied for their promising antibacterial properties due to their action on different microbial targets. Here we assess the recent development of this class of compounds to address mechanisms underlying antibiotic resistance at both bacterial-cell and community levels (biofilms). We also explore the SAR and the prospective clinical application of thiazole and its benzofused derivatives, which act as inhibitors of mechanisms underlying antibiotic resistance in the treatment of severe drug-resistant infections. In addition, we examined all bacterial targets involved in their antimicrobial activity reporting, when described, their spontaneous frequencies of resistance.

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Section: Antibacterial Activity Of Thiazole Derivatives With Unknown ...mentioning

confidence: 99%

Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

et al. 2020

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“…In our own hands, we have observed the antibacterial activity of {Au(PPh 3 )} + complexes 35 and 36 with benzothiazoles as ligands (Figure 6). [51] A skin and soft tissue infection model was used to evaluate their antibacterial efficacy against Acinetobacter baumannii and P. aeruginosa , two Gram‐negative pathogens. Both complexes showed significant bacterial lawn clearing in case of A. baumannii while the control [Cl−Au(PPh 3 )] showed no effect using this method.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Gold Drugs with {Au(PPh₃)}⁺ Moiety: Advantages and Medicinal Applications

Stenger-Smith

Mascharak

2020

ChemMedChem

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Following the success of Auranofin as an anti-arthritic drug, search for novel gold drugs has afforded a large number of [LÀ Au(PPh 3)] complexes that exhibit notable salutary effects. Unlike Au(III)-containing species, these gold complexes with {Au (PPh 3)} + moiety are stable in biological media and readily exchange L with Sand Se-containing enzymes or proteins. Such exchange leads to rapid reduction of microbial loads or induction of apoptotic cell death at malignant sites. In many cases the lipophilic {Au(PPh 3)} + moiety delivers a desirable toxic L to the specific cellular target in addition to exhibiting its own beneficial activity. Further research and utilization of this synthon in drug design could lead to novel chemotherapeutics for treatment of drug-resistant pathogens and cancers.

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“…Benzothiazoles are important bicyclic organic compounds that are used in organic synthesis , or as important ligands in the synthesis of metallic complexes. , Typically, benzothiazoles used in the inorganic field possess effective donor atoms and mostly coordinate in a monodentate manner through the nitrogen atom , or sometimes through the sulfur atom . The importance of benzothiazoles as ligands is increased through benzothiazole derivatives containing additional donor atoms, such as nitrogen, sulfur, or oxygen, that can coordinate bidentately through two nitrogen atoms , or nitrogen and oxygen atoms …”

Section: Introductionmentioning

confidence: 99%

Synthesis and Structural Characterization of Palladium(II) Mixed-Ligand Complexes of N-(Benzothiazol-2-yl)benzamide and 1,2-Bis(diphenylphosphino)ethane

et al. 2021

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Three novel palladium(II) mixed-ligand complexes of N-(benzothiazol-2-yl)benzamide (HL) and 1,2-bis(diphenylphosphino)ethane (dppe), [Pd(HL)(dppe)]Cl2 (1), [Pd(L)(dppe)]Cl (2), and [Pd(L)2(dppe)] (3), were synthesized and fully characterized using Fourier transform infrared, 1H, 13C, and 31P NMR, and molar conductivity measurements. Complex 3 was characterized by single-crystal X-ray diffraction. The ligand HL showed three different coordination modes: a neutral bidentate chelate bound through the endocyclic nitrogen and exocyclic oxygen atoms in 1, a negatively charged L bound as a bidentate chelate through the endocyclic nitrogen and negatively charged exocyclic oxygen atoms in 2, and a monodentate bound through the negatively charged endocyclic nitrogen atom in 3.

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Cationic Au(I) complexes with aryl-benzothiazoles and their antibacterial activity

Cited by 19 publications

References 29 publications

Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

Gold Drugs with {Au(PPh₃)}⁺ Moiety: Advantages and Medicinal Applications

Synthesis and Structural Characterization of Palladium(II) Mixed-Ligand Complexes of N-(Benzothiazol-2-yl)benzamide and 1,2-Bis(diphenylphosphino)ethane

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Cationic Au(I) complexes with aryl-benzothiazoles and their antibacterial activity

Cited by 19 publications

References 29 publications

Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

Gold Drugs with {Au(PPh3)}+ Moiety: Advantages and Medicinal Applications

Synthesis and Structural Characterization of Palladium(II) Mixed-Ligand Complexes of N-(Benzothiazol-2-yl)benzamide and 1,2-Bis(diphenylphosphino)ethane

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Gold Drugs with {Au(PPh₃)}⁺ Moiety: Advantages and Medicinal Applications