Cationic and amphiphilic peptide-based hydrogels with dual activities as anticancer and antibacterial agents

Abstract

The emergence of peptide-based functional biomaterials is on trend. To fulfil this purpose, a series of amphiphilic peptides such as H2N-X-Met-Phe-C12H25 where, X= L-Lysine (CP1), X = L-Histidine (CP2), and...

Self-assembling short peptide amphiphiles as versatile delivery agents: a new frontier in antibacterial research

“…37–39 Conversely, lipidated amphiphiles comprise hydrophobic lipid chains attached to hydrophilic amino acid groups, making them biomimetic and known as lipopeptides. The self-assembly behavior of these molecules is dictated by their arrangement and composition, primarily driven by the interplay between hydrophilic and hydrophobic interactions, as elucidated by seminal works by Stupp et al and Banerjee et al 35,40,41…”

“…These complexes may exert antibacterial activity through various mechanisms, including disruption of bacterial cell membranes, generation of reactive oxygen species (ROS), interference with essential cellular processes, or induction of bacterial cell death pathways. 40,41 By detailing these mechanisms, we aim to provide clarity on how PA-metal complexes exert their antibacterial effects. Furthermore, we recognize the importance of addressing selectivity for bacteria versus mammalian cells (Fig.…”