Cationic amphiphilic non-hemolytic polyacrylates with superior antibacterial activity

Punia, Ashish; He, Edward; Lee, Kevin; Yang, Nan‐Loh

doi:10.1039/c4cc01583e

Cited by 53 publications

(59 citation statements)

References 19 publications

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“…Alkyl spacer length dependent activity was also observed for the antimicrobial poly(acrylate) copolymers developed by Yang and coworkers [73]. They used monomers having 2-carbon or 6-carbon spacers linking primary ammonium groups (Table 1C).…”

Section: Alkyl Spacers and Tailsmentioning

confidence: 82%

“…They observed certain threshold percentages of cationic and hydrophobic content that achieved best antibacterial activity. Antimicrobial poly(acrylate) copolymers with superior antibacterial activity were developed by Yang and co-workers [73]. They used monomers with various spacers linking primary ammonium groups (Table 1E) to modulate the activity.…”

Section: Random Copolymersmentioning

confidence: 99%

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Controlling macromolecular structures towards effective antimicrobial polymers

Ganewatta

Tang

2015

Polymer

219

255

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Section: Alkyl Spacers and Tailsmentioning

confidence: 82%

Section: Random Copolymersmentioning

confidence: 99%

Controlling macromolecular structures towards effective antimicrobial polymers

Ganewatta

Tang

2015

Polymer

219

255

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“…In order to overcome these drawbacks, a new approach is the development of synthetic mimics of AMPs based on small molecules or polymers. 11–13 We have previously developed synthetic methacrylate random copolymers consisting cationic and hydrophobic side chains as a synthetic mimic of cationic amphiphilic AMPs. 14–15 These random copolymers are designed to mimic the membrane-disruptive mechanism of AMPs, but not necessarily secondary structures of AMPs such as α-helices.…”

Section: Introductionmentioning

confidence: 99%

Cationic Amphiphilic Polymers with Antimicrobial Activity for Oral Care Applications: Eradication of S. mutans Biofilm

2016

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The anti-bacterial and anti-biofilm activities of cationic amphiphilic methacrylate polymers against cariogenic bacterium S. mutans were investigated. Cationic homopolymer PE0 and copolymer PE31 containing 31 mole% of ethyl methacrylate were synthesized by reversible addition-fragmentation chain transfer polymerization. These polymers displayed bactericidal activity towards S. mutans and prevented biofilm formation by killing the planktonic bacteria. At a concentration of 1000 μg/mL when incubated for 2 hours the polymers reduced more than 80% of biofilm biomass. When the polymer assay solution with the biofilm was vigorously mixed using a pipette for 30 seconds, more than 50% of biofilm mass was removed at a polymer concentration of 250 μg/mL. Chlorhexidine and a cationic surfactant failed to reduce the biofilm mass at the same concentration. PE0 was the most effective in removing biofilm and did not show any significant cytotoxicity to human gingival fibroblast and periodontal ligament stem cells when incubated for 10 minutes.

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“…Similar results were observed for poly(norbornene) copolymers when extended by either zwitterionic, sugar or PEG moieties. 31 In the case of polyacrylics, a complete exchange of the hydrophobic component (HEMA 32 or PEGMA 33 ) still results in antimicrobial polymers. However, it is unclear whether these systems still target the bacterial membrane like other AMP mimics.…”

Section: Beyond Cationic and Hydrophobic Unitsmentioning

confidence: 99%

“…This concept was further investigated by Yang and coworkers, combining a C 6 spacer, primary amine monomer with a C 2 spacer, secondary amine monomer in different ratios to obtain optimal selectivity. 33 …”

Section: Spacer Lengthmentioning

confidence: 99%

Antimicrobial Polymers: Mimicking Amino Acid Functionali ty, Sequence Control and Three-dimensional Structure of Host-defen se Peptides

Hartlieb

Williams

Kuroki

et al. 2017

CMC

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(2017) Antimicrobial polymers : mimicking amino acid functionality, sequence control and threedimensional structure of host-defense peptides. Current Medicinal Chemistry, 24 . Permanent WRAP URL:http://wrap.warwick.ac.uk/88727 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. Publisher's statement:The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/149294/article A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP URL' above for details on accessing the published version and note that access may require a subscription. Abstract: Peptides and proteins control and direct all aspects of cellular function and communication.Having been honed by nature for millions of years, they also typically display an unsurpassed specificity for their biological targets. This underlies the continued focus on peptides as promising drug candidates. However, the development of peptides into viable drugs is hampered by their lack of chemical and pharmacokinetic stability and the cost of large scale production. One method to overcome such hindrances is to develop polymer systems that are able to retain the important structural features of these biologically active peptides, while being cheaper and easier to produce and manipulate chemically.This review illustrates these principles using examples of polymers designed to mimic antimicrobial host-defence peptides. The host-defence peptides have been identified as some of the most important leads for the next generation of antibiotics as they typically exhibit broad spectrum antimicrobial ability, low toxicity toward human cells and little susceptibility to currently known mechanisms of bacterial resistance. Their movement from the bench to clinic is yet to be realised, however, due to the limitations of these peptides as drugs. The literature provides a number of examples of polymers that have been able to mimic these peptides through all levels of structure, starting from specific amino acid sidechains, through to more global features such as overall charge, molecular weight and three-dimensional structure (e.g. α-helical). The resulting optimised polymers are able ret...

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Cationic amphiphilic non-hemolytic polyacrylates with superior antibacterial activity

Cited by 53 publications

References 19 publications

Controlling macromolecular structures towards effective antimicrobial polymers

Controlling macromolecular structures towards effective antimicrobial polymers

Cationic Amphiphilic Polymers with Antimicrobial Activity for Oral Care Applications: Eradication of S. mutans Biofilm

Antimicrobial Polymers: Mimicking Amino Acid Functionali ty, Sequence Control and Three-dimensional Structure of Host-defen se Peptides

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