Cation-Exchangeable Pralidoxime Chloride@bio-MOF-1 as a Treatment for Nerve Agent Poisoning and Sulfur Mustard Skin Poisoning in Animals

Yang, Yang; Liu, Jie; Liu, Lin; Zhou, Yunshan; Zhang, Lijuan; Zhong, Yuxu; Zhao, Dianfa; Wang, Yong'an

doi:10.1021/acsomega.2c01240

Cited by 4 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[5][6][7][8][9][10][11]. These isosbestic points indicate the presence of only two species in equilibrium, andthey are directly related to changes in the iron coordination sphere.…”

mentioning

confidence: 90%

“…[1,2] This includes using of phosphate triesters (PT) as insecticides. [3] However, due to their inherent toxicity, [4][5][6] there has been a growing interest in exploring a safe and secure way to destroy these compounds, ranging from physical procedures such as adsorption [7,8] and chemical methodologies employing nanocarriers, [9][10][11] bacteria, [12] to enzymatic hydrolysis. [6,[13][14][15][16][17][18] Phosphatases are one of these enzymes that specifically target and break the PÀ O bonds.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phosphate Triester Hydrolysis by Mononuclear Iron(III) Complexes: The Role of Benzimidazole in the Second Coordination Sphere

Luiz,

Farias,

Alzamora

et al. 2024

Eur J Inorg Chem

View full text Add to dashboard Cite

Over the years, phosphate ester hydrolysis promoted by coordination compounds has attracted extensive research on developing new bioinspired compounds. However, the literature lacks sufficient examples displaying activity toward phosphate triesters specifically, limiting the understanding of efficient strategies for its hydrolysis. Herein, we report the preparation and characterization of three mononuclear iron(III) complexes (1, 2, and 3) and their hydrolase‐like activity. Complexes 2 and 3 contained benzimidazole (BIMZ) moieties and were strategically designed to separate the BIMZ moiety from the first coordination sphere, and complex 1 was used as a reference. Several techniques provided structural information, including spectrophotometry, spectrometry, electrochemistry, elemental analysis, and 57Fe Mossbauer. Density functional theory (DFT) revealed distorted octahedral geometries due to the presence of the BIMZ groups. These groups also directly affected the protonation equilibria and catalytic activity. The phosphate triester diethyl‐2,4‐dinitrophenylphosphate (DEDNPP) hydrolysis was enhanced at least 27 times compared to the uncatalyzed reaction, with complexes 2 and 3, containing the BIMZ moiety showing higher catalytic rates (kcat). Moreover, a longer carbon chain led to a higher hydrolysis rate but less interaction with substrate. These findings provide a foundation for further investigations and developing into efficient catalysts for agrochemical degradation.

show abstract

“…[5][6][7][8][9][10][11]. These isosbestic points indicate the presence of only two species in equilibrium, andthey are directly related to changes in the iron coordination sphere.…”

mentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Phosphate Triester Hydrolysis by Mononuclear Iron(III) Complexes: The Role of Benzimidazole in the Second Coordination Sphere

Luiz,

Farias,

Alzamora

et al. 2024

Eur J Inorg Chem

View full text Add to dashboard Cite

show abstract

MOF based nanocomposites for photocatalytic degradation of pollutants in water: A critical review

Chabalala,

Mothudi,

Ntsendwana

2024

Journal of Photochemistry and Photobiology A: Chemistry

View full text Add to dashboard Cite

Preparation and sustained-release study of Litsea cubeba essential oil inclusion complex with γ-cyclodextrin-metal–organic frameworks

Zheng,

Zhang,

Chen

2023

Chem. Biol. Technol. Agric.

View full text Add to dashboard Cite

Background Litsea cubeba essential oil (LCEO) is a food additive that requires encapsulation to delay its release due to its irritating nature. To identify an appropriate inclusion material, gamma (γ)-cyclodextrin (CD)-metal organic frameworks (MOF) were prepared, and the sustained release of the inclusion complex (IC) was studied. Results The γ-CD-MOF was formed using γ-CD, potassium hydroxide (KOH), cetyltrimethylammonium bromide (CTAB), and silane coupling agents through the vapor diffusion method. The highest encapsulated rate achieved was 26.02%, with a temperature of 50 °C, a stirring time of 2.5 h, and an LCEO to γ-CD dosage ratio of 1:8. During the adsorption test, the amount of LCEO gradually increased within the first 180 min. However, after this time, there was no significant change in the adsorption amount of LCEO, indicating that the γ-CD-MOF had reached adsorption equilibrium. The average release rate of the IC reached 9.76% at 11 h. By comparison, the average release rate of the IC with γ-CD was 9.30% at 10 min, resulting in a diffusion index of 0.349. Under ultraviolet (UV) scanning, the sustained-release solution of the IC exhibited a strong characteristic citral absorption peak at 238 nm. Moreover, under infrared spectroscopy scanning, the absorption peak intensity of the IC was 1.19 times higher than that of blank γ-CD-MOF at 1676 cm−1. The IC, as observed through a scanning electron microscope, exhibited round pellets with a diameter of 40–60 μm. Energy dispersive spectroscopy images showed uniform distribution of potassium and sulfur elements. In X-Ray diffraction, the diffraction peaks of the IC were found at 5.27°, 7.45°, 10.54°, 12.08°, 14.20°, 14.92°, 15.84°, 16.68°, 19.24°, 21.80°, and 23.69°, with no significant change in the adsorption amount of LCEO. The Brunauer–Emmett–Teller (BET) testing revealed that the surface area of γ-CD-MOF was 5.089 m2/g, and the pore diameter was 3.409 nm by the Barrett–Joyner–Halenda (BJH) method. Conclusion These data demonstrated that the sustained effect of the γ-CD-MOF was superior to that of γ-CD. The adsorption kinetics curve followed the Quasi-primary kinetics model, while the release curve adhered to the Ritger–Peppas model. Furthermore, the release behavior was primarily governed by the Fick diffusion mechanism, which was advantageous for achieving the sustained release of LCEO. The UV spectrum, infrared spectroscopy (IR), scanning electron microscopy–energy dispersive spectroscopy (SEM–EDS), X-ray diffraction (XRD), and BET techniques confirmed the successful formation of the IC of LCEO with γ-CD-MOF. This study offers a promising technical solution for delaying the release and improving the sustained-release product of LCEO. Graphical Abstract

show abstract

Cation-Exchangeable Pralidoxime Chloride@bio-MOF-1 as a Treatment for Nerve Agent Poisoning and Sulfur Mustard Skin Poisoning in Animals

Cited by 4 publications

References 32 publications

Phosphate Triester Hydrolysis by Mononuclear Iron(III) Complexes: The Role of Benzimidazole in the Second Coordination Sphere

Phosphate Triester Hydrolysis by Mononuclear Iron(III) Complexes: The Role of Benzimidazole in the Second Coordination Sphere

MOF based nanocomposites for photocatalytic degradation of pollutants in water: A critical review

Preparation and sustained-release study of Litsea cubeba essential oil inclusion complex with γ-cyclodextrin-metal–organic frameworks

Contact Info

Product

Resources

About